New User Interface Architecture for Netwiser Product with Angularjs
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CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout
Published OnlineFirst August 16, 2016; DOI: 10.1158/0008-5472.CAN-16-1272 Cancer Tumor and Stem Cell Biology Research CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma Josephine Walton1,2, Julianna Blagih3, Darren Ennis1, Elaine Leung1, Suzanne Dowson1, Malcolm Farquharson1, Laura A. Tookman4, Clare Orange5, Dimitris Athineos3, Susan Mason3, David Stevenson3, Karen Blyth3, Douglas Strathdee3, Frances R. Balkwill2, Karen Vousden3, Michelle Lockley4, and Iain A. McNeish1,4 Abstract – – There is a need for transplantable murine models of ovarian ating novel ID8 derivatives that harbored single (Trp53 / )or – – – – high-grade serous carcinoma (HGSC) with regard to mutations in double (Trp53 / ;Brca2 / ) suppressor gene deletions. In these the human disease to assist investigations of the relationships mutants, loss of p53 alone was sufficient to increase the growth between tumor genotype, chemotherapy response, and immune rate of orthotopic tumors with significant effects observed on the microenvironment. In addressing this need, we performed whole- immune microenvironment. Specifically, p53 loss increased exome sequencing of ID8, the most widely used transplantable expression of the myeloid attractant CCL2 and promoted the model of ovarian cancer, covering 194,000 exomes at a mean infiltration of immunosuppressive myeloid cell populations into – – – – depth of 400Â with 90% exons sequenced >50Â. We found no primary tumors and their ascites. In Trp53 / ;Brca2 / mutant functional mutations in genes characteristic of HGSC (Trp53, cells, we documented a relative increase in sensitivity to the PARP Brca1, Brca2, Nf1, and Rb1), and p53 remained transcriptionally inhibitor rucaparib and slower orthotopic tumor growth – – active. Homologous recombination in ID8 remained intact in compared with Trp53 / cells, with an appearance of intratumoral þ functional assays. -
SHOW TEASE: It's Time for Security Now!. Steve Gibson Is Here. We're Going to Talk About the Strange Case of the Estonian ID Cards
Security Now! Transcript of Episode #642 Page 1 of 30 Transcript of Episode #642 BGP Description: This week we examine how Estonia handled the Infineon crypto bug; two additional consequences of the pressure to maliciously mine cryptocurrency; zero-day exploits in the popular vBulletin forum system; Mozilla in the doghouse over "Mr. Robot"; Win10's insecure password manager mistake; when legacy protocol come back to bite us; how to bulk-steal any Chrome user's entire stored password vault; and we finally know where and why the uber-potent Mirai botnet was created, and by whom. We also have a bit of errata and some fun miscellany. Then we're going to take a look at BGP, another creaky yet crucial - and vulnerable - protocol that glues the global Internet together. High quality (64 kbps) mp3 audio file URL: http://media.GRC.com/sn/SN-642.mp3 Quarter size (16 kbps) mp3 audio file URL: http://media.GRC.com/sn/sn-642-lq.mp3 SHOW TEASE: It's time for Security Now!. Steve Gibson is here. We're going to talk about the strange case of the Estonian ID cards. A weird bug or actually flaw introduced into Microsoft's Windows 10. We're still not sure exactly who got it and why. We'll also talk about the case of the Firefox plugin promoting "Mr. Robot," and a whole lot more, all coming up next on Security Now!. Leo Laporte: This is Security Now! with Steve Gibson, Episode 642, recorded Tuesday, December 19th, 2017: BGP. It's time for Security Now!, the show where we cover your security online with this guy right here, the Explainer in Chief, Steve Gibson. -
Pragmatic Guide to Javascript
www.allitebooks.com What Readers Are Saying About Pragmatic Guide to J a v a S c r i p t I wish I had o w n e d this book when I first started out doing JavaScript! Prag- matic Guide to J a v a S c r i p t will take you a big step ahead in programming real-world JavaScript by showing you what is going on behind the scenes in popular JavaScript libraries and giving you no-nonsense advice and back- ground information on how to do the right thing. W i t h the condensed years of e x p e r i e n c e of one of the best JavaScript developers around, it’s a must- read with great reference to e v e r y d a y JavaScript tasks. Thomas Fuchs Creator of the script.aculo.us framework An impressive collection of v e r y practical tips and tricks for getting the most out of JavaScript in today’s browsers, with topics ranging from fundamen- tals such as form v a l i d a t i o n and JSON handling to application e x a m p l e s such as mashups and geolocation. I highly recommend this book for anyone wanting to be more productive with JavaScript in their web applications. Dylan Schiemann CEO at SitePen, cofounder of the Dojo T o o l k i t There are a number of JavaScript books on the market today, b u t most of them tend to focus on the new or inexperienced JavaScript programmer. -
THE FUTURE of SCREENS from James Stanton a Little Bit About Me
THE FUTURE OF SCREENS From james stanton A little bit about me. Hi I am James (Mckenzie) Stanton Thinker / Designer / Engineer / Director / Executive / Artist / Human / Practitioner / Gardner / Builder / and much more... Born in Essex, United Kingdom and survived a few hair raising moments and learnt digital from the ground up. Ok enough of the pleasantries I have been working in the design field since 1999 from the Falmouth School of Art and onwards to the RCA, and many companies. Ok. less about me and more about what I have seen… Today we are going to cover - SCREENS CONCEPTS - DIGITAL TRANSFORMATION - WHY ASSETS LIBRARIES - CODE LIBRARIES - COST EFFECTIVE SOLUTION FOR IMPLEMENTATION I know, I know, I know. That's all good and well, but what does this all mean to a company like mine? We are about to see a massive change in consumer behavior so let's get ready. DIGITAL TRANSFORMATION AS A USP Getting this correct will change your company forever. DIGITAL TRANSFORMATION USP-01 Digital transformation (DT) – the use of technology to radically improve performance or reach of enterprises – is becoming a hot topic for companies across the globe. VERY DIGITAL CHANGING NOT VERY DIGITAL DIGITAL TRANSFORMATION USP-02 Companies face common pressures from customers, employees and competitors to begin or speed up their digital transformation. However they are transforming at different paces with different results. VERY DIGITAL CHANGING NOT VERY DIGITAL DIGITAL TRANSFORMATION USP-03 Successful digital transformation comes not from implementing new technologies but from transforming your organisation to take advantage of the possibilities that new technologies provide. -
Using the Dojo Toolkit in a Webworks Application Michelle Mendoza RIM Developer Relations Dylan Schiemann Co-Founder of Dojo Toolkit & CEO of Sitepen Inc
Using the Dojo Toolkit in a WebWorks application Michelle Mendoza RIM Developer Relations Dylan Schiemann Co-founder of Dojo Toolkit & CEO of SitePen Inc. Agenda What is Dojo? Using the Dojo Mobile package Dojo Mobile Application Demos Basic Code Walkthrough Q&A 2 Dojo Toolkit Build sophisticated Web apps http://dojotoolkit.org/ Supports multiple browsers Enables rapid development Philosophy: Push the limits (SVG, WebGL, HTML5) Define & adopt defacto standards Developer productivity & tools Open, free & liberally licensed Toolkit Components Dojo – also known as “core”, AJAX, DOM manipulation, class-like programming, events Dijit – extensive set of UI components known as widgets DojoX – collection of packages and modules built upon Dojo core and Dijit dojox/mobile dojox/gfx dojox/charting and many more Util – utility scripts Create optimized builds DOH: Dojo Objective Harness 4 Dojo 1.8 Dojo 1.8 Improvements Performance optimizations New widgets added 175 sub-packages and 1400 modules Much improved documentation 5 AMD - Asynchronous Module Definition Mechanism allows modules and dependencies to be loaded asynchronously Asynchronous format reduces app loading time Better performance, easier code handling Only load the modules you require Dojo has a lightweight AMD loader of < 4kb Reduce page load time by up to 10x 6 Interactive Experience Grid displays Dynamic charts Various Form Controls and Form Validators Cross Platform graphics Mapping using OpenLayers Animated effects Gauges 7 Interactive Experience -
Paweł Rajba [email protected]
Paweł Rajba [email protected] http://itcourses.eu/ Wprowadzenie Zalety Wady XMLHttpRequest AJAX w praktyce AJAX + jQuery SOP, CORS i JSONP Literatura Z czego się składa? . JavaScript + DOM . Obiekt XMLHttpRequest . Jakakolwiek technologia po stronie serwera AJAX to nic nowego (w pewnym sensie) . Technoogie w roku 1998 . Artykuł Jesse James Garreta w roku 2005 Jak to działa? . Nagłówek X-Requested-With: XMLHttpRequest Aplikacje są bardziej interaktywne . Szybsza aktualizacja treści na stronie . Mniejsze zużycie pasma Daje możliwość tworzenia bardziej rozbudowanych interfejsów użytkownika Wykorzystuje istniejące technologie Domyślnie aplikacja widoczna pod tylko jednym adresem: . Nie działa przycisk wstecz, który wg raportu Jacoba Nielsena jest pod drugą pod względem użyteczności funkcją nawigacyjną . Stan aplikacji jest reprezentowany przez adres URL ▪ przez co nie można go zapisać np. do zakładek ▪ uniemożliwia to reklamę ,,pantoflową’’ jak też zwykłe przesyłanie linków znajomym . Można to obejść, ale wymaga dodatkowej pracy Silniki wyszukiwarek mogą mieć problemy z poprawnym indeksowaniem stron Trudniej debugować Trudniej testować Metody obiektu XMLHttpRequest . abort() – przerywa żądanie . getResponseHeader( klucz ) – pobiera wartość pola nagłówka http . open( metoda, Uri, [async, [nazwa_użytkownika, [hasło]]]) – określa parametry żądania: ▪ metoda – GET lub POST ▪ Uri – adres żądania ▪ async – czy asynchronicznie (domyślnie true) ▪ użytkownik, hasło – możemy podać, jeśli dostęp do zasobu wymaga uwierzytelnienia -
Silkperformer® 2010 R2 Release Notes Borland Software Corporation 4 Hutton Centre Dr., Suite 900 Santa Ana, CA 92707
SilkPerformer® 2010 R2 Release Notes Borland Software Corporation 4 Hutton Centre Dr., Suite 900 Santa Ana, CA 92707 Copyright 2009-2010 Micro Focus (IP) Limited. All Rights Reserved. SilkPerformer contains derivative works of Borland Software Corporation, Copyright 1992-2010 Borland Software Corporation (a Micro Focus company). MICRO FOCUS and the Micro Focus logo, among others, are trademarks or registered trademarks of Micro Focus (IP) Limited or its subsidiaries or affiliated companies in the United States, United Kingdom and other countries. BORLAND, the Borland logo and SilkPerformer are trademarks or registered trademarks of Borland Software Corporation or its subsidiaries or affiliated companies in the United States, United Kingdom and other countries. All other marks are the property of their respective owners. ii Contents SilkPerformer Release Notes ..............................................................................4 What's New in SilkPerformer 2010 R2 ...............................................................5 Browser-Driven Load Testing Enhancements .......................................................................5 Enhanced Support for Large-Scale Load Testing .................................................................6 Support for Testing BlazeDS Server Applications .................................................................7 Support for Custom Terminal Emulation Screen Sizes .........................................................7 Graceful Disconnect for Citrix Sessions ................................................................................7 -
HCI Lessons Using AJAX for a Page-Turning Web Application
CHI 2011 • Session: Reading & Writing May 7–12, 2011 • Vancouver, BC, Canada Bells, Whistles, and Alarms: HCI Lessons Using AJAX for a Page-turning Web Application Juliet L. Hardesty Abstract User Interface Design Specialist This case study describes creating a version of METS Digital Library Program Navigator, a page-turning web application for multi- Indiana University part digital objects, using an AJAX library with user Herman B Wells Library, W501 interface components. The design for this version 1320 E. 10th Street created problems for customized user interactions and Bloomington, IN 47405 USA accessibility problems for users, including those using [email protected] assistive technologies and mobile devices. A review of the literature considers AJAX, accessibility, and universal usability and possible steps to take moving forward to correct these problems in METS Navigator. Keywords AJAX, accessibility, universal usability ACM Classification Keywords H.5.2. Information interfaces and presentation: User interfaces - user-centered design, standardization. General Terms Design, human factors, standardization Copyright is held by the author/owner(s). CHI 2011, May 7–12, 2011, Vancouver, BC, Canada. Introduction ACM 978-1-4503-0268-5/11/05. AJAX (Asynchronous JavaScript and XML) is a widely used method for developing Web 2.0 applications 827 CHI 2011 • Session: Reading & Writing May 7–12, 2011 • Vancouver, BC, Canada (called Rich Internet Applications, or RIA’s), both to incorporate the Semantic Web into Web 2.0 enhance certain features -
Angularjs Native Rich Clients with Eclipse RCP WEB APPS UNTIL NOW
Die Grundlagen Philipp Burgmer theCodeCampus / Weigle Wilczek GmbH ABOUT ME Philipp Burgmer Software Engineer / Consultant / Trainer Focus: Frontend, Web Technologies WeigleWilczek GmbH [email protected] ABOUT US WeigleWilczek / W11k Software Design, Development & Maintenance Consulting, Trainings & Project Kickoff Web Applications with AngularJS Native Rich Clients with Eclipse RCP WEB APPS UNTIL NOW JSF UI on Server A lot HTTP Requests Just to Update UI Hard to Use JS Libs / Scatters UI Logic GWT UI in Java / XML Hard to Use JS Libs / Scatters UI Logic "Java World" Instead of "Web World" Flex Clean Separation of Front- and Backend Based on Flash, Adobe Discontinues Developement MXML and ActionScript Instead of HTML and JavaScript WEB APPS FROM NOW ON Frontend Runs Completely in the Browser Stateful UI, Stateless Server Server Delivers Static Resources Server Delivers Dynamic Data HTML, CSS and JavaScript as UI Toolkit WHAT IS ANGULARJS? HTML Enhanced for Web Apps angularjs.com Client / Browser JS Framework Rich Browser Applications Brings Core Frontend Concepts and Features to the Browser Extends HTML Instead of Abstracting or Wrapping It angularjs.org Current Versions: 1.2.23 and 1.3.0-beta.19 License: MIT CORE CONCEPTS Model View Controller Modules Pattern Dependency Injection Two Way Data-Binding Services Directives Filter Goals Separation of Concerns Make It Easier to Write Clean Code Make It Easier to Write Testable Code Offer Concepts and Be Open for Extensions DEMO Two Way Data-Binding [ JS Bin | localhost ] Add Logic with a Controller -
Learning Javascript Design Patterns
Learning JavaScript Design Patterns Addy Osmani Beijing • Cambridge • Farnham • Köln • Sebastopol • Tokyo Learning JavaScript Design Patterns by Addy Osmani Copyright © 2012 Addy Osmani. All rights reserved. Revision History for the : 2012-05-01 Early release revision 1 See http://oreilly.com/catalog/errata.csp?isbn=9781449331818 for release details. ISBN: 978-1-449-33181-8 1335906805 Table of Contents Preface ..................................................................... ix 1. Introduction ........................................................... 1 2. What is a Pattern? ...................................................... 3 We already use patterns everyday 4 3. 'Pattern'-ity Testing, Proto-Patterns & The Rule Of Three ...................... 7 4. The Structure Of A Design Pattern ......................................... 9 5. Writing Design Patterns ................................................. 11 6. Anti-Patterns ......................................................... 13 7. Categories Of Design Pattern ............................................ 15 Creational Design Patterns 15 Structural Design Patterns 16 Behavioral Design Patterns 16 8. Design Pattern Categorization ........................................... 17 A brief note on classes 17 9. JavaScript Design Patterns .............................................. 21 The Creational Pattern 22 The Constructor Pattern 23 Basic Constructors 23 Constructors With Prototypes 24 The Singleton Pattern 24 The Module Pattern 27 iii Modules 27 Object Literals 27 The Module Pattern -
The Snap Framework: a Web Toolkit for Haskell
The Functional Web The Snap Framework A Web Toolkit for Haskell Gregory Collins • Google Switzerland Doug Beardsley • Karamaan Group askell is an advanced functional pro- the same inputs, always produce the same out- gramming language. The product of more put. This property means that you almost always H than 20 years of research, it enables rapid decompose a Haskell program into smaller con- development of robust, concise, and fast soft- stituent parts that you can test independently. ware. Haskell supports integration with other Haskell’s ecosystem also includes many power- languages and has loads of built-in concurrency, ful testing and code-coverage tools. parallelism primitives, and rich libraries. With Haskell also comes out of the box with a set its state-of-the-art testing tools and an active of easy-to-use primitives for parallel and con- community, Haskell makes it easier to produce current programming and for performance pro- flexible, maintainable, high-quality software. filing and tuning. Applications built with GHC The most popular Haskell implementation is enjoy solid multicore performance and can han- the Glasgow Haskell Compiler (GHC), a high- dle hundreds of thousands of concurrent net- performance optimizing native-code compiler. work connections. We’ve been delighted to find Here, we look at Snap, a Web-development that Haskell really shines for Web programming. framework for Haskell. Snap combines many other Web-development environments’ best fea- What’s Snap? tures: writing Web code in an expressive high- Snap offers programmers a simple, expressive level language, a rapid development cycle, fast Web programming interface at roughly the same performance for native code, and easy deploy- level of abstraction as Java servlets. -
Practical Javascript™, DOM Scripting, and Ajax Projects
Practical JavaScript™, DOM Scripting, and Ajax Projects ■■■ Frank W. Zammetti Practical JavaScript™, DOM Scripting, and Ajax Projects Copyright © 2007 by Frank W. Zammetti All rights reserved. No part of this work may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage or retrieval system, without the prior written permission of the copyright owner and the publisher. ISBN-13 (pbk): 978-1-59059-816-0 ISBN-10 (pbk): 1-59059-816-4 Printed and bound in the United States of America 9 8 7 6 5 4 3 2 1 Trademarked names may appear in this book. Rather than use a trademark symbol with every occurrence of a trademarked name, we use the names only in an editorial fashion and to the benefit of the trademark owner, with no intention of infringement of the trademark. Java and all Java-based marks are trademarks or registered trademarks of Sun Microsystems, Inc., in the United States and other countries. Apress, Inc., is not affiliated with Sun Microsystems, Inc., and this book was written without endorsement from Sun Microsystems, Inc. Lead Editor: Matthew Moodie Technical Reviewer: Herman van Rosmalen Editorial Board: Steve Anglin, Ewan Buckingham, Gary Cornell, Jason Gilmore, Jonathan Gennick, Jonathan Hassell, James Huddleston, Chris Mills, Matthew Moodie, Jeff Pepper, Paul Sarknas, Dominic Shakeshaft, Jim Sumser, Matt Wade Project Manager: Tracy Brown Collins Copy Edit Manager: Nicole Flores Copy Editor: Marilyn Smith Assistant Production Director: Kari Brooks-Copony Production Editor: Laura Esterman Compositor: Susan Glinert Proofreaders: Lori Bring and April Eddy Indexer: Broccoli Information Management Cover Designer: Kurt Krames Manufacturing Director: Tom Debolski Distributed to the book trade worldwide by Springer-Verlag New York, Inc., 233 Spring Street, 6th Floor, New York, NY 10013.