December 18, 2018 u vol. 115 u no. 51

From the Cover

12868 and antimicrobial resistance E11904 Protein translation in Lou Gehrig’s disease E11933 Molecular motor autoinhibition E12091 Atopic dermatitis and oxidative stress

Contents

THIS WEEK IN PNAS 12829 In This Issue Cover image: Pictured is a scanning electron micrograph of Staphylococcus LETTERS (ONLINE ONLY) aureus bacteria (red) attacking a human E11886 Urban isolation and daytime neighborhood social composition from leukemia cell (blue). Articles in the Twitter data Antimicrobial Resistance and the Role of Julie Valle´e Vaccines Special Feature present arguments in favor of increasing E11888 Reply to Vallée: Different questions for different data coverage of existing vaccines and Qi Wang, Nolan Edward Phillips, Mario L. Small, and Robert J. Sampson developing new vaccines as a significant E11890 Increasing exercise’s effect on mental health: Exercise intensity does matter part of strategies to combat Thomas Gronwald, Bruna Velasques, Pedro Ribeiro, Sergio Machado, Eric Murillo-Rodrı´guez, antimicrobial resistance. Vaccines offer Sebastian Ludyga, Tetsuya Yamamoto, and Henning Budde advantages over antibiotics in terms of E11892 Reply to Gronwald et al.: Exercise intensity does indeed matter; maximal the likelihood of resistance and oxygen uptake is the gold-standard indicator interactions with the microbiome. Kazuya Suwabe, Kyeongho Byun, Kazuki Hyodo, Zachariah M. Reagh, Jared M. Roberts, Akira Further, the ability of vaccines to reduce Matsushita, Kousaku Saotome, Genta Ochi, Takemune Fukuie, Kenji Suzuki, Yoshiyuki Sankai, antibiotic use and resistance has been Michael A. Yassa, and Hideaki Soya documented. See the Introduction to the Special Feature by David E. Bloom et al. on pages 12868–12871. Image SCIENCE AND CULTURE—How science intersects with culture courtesy of Ilaria Ferlenghi and Fabiola 12832 Imagining a climate-change future, without the dystopia Giusti (GlaxoSmithKline, London). Gayathri Vaidyanathan

INNER WORKINGS—An over-the-shoulder look at scientists at work 12836 Astronomers track dwarf galaxies to better understand the Milky Way’s make-up and evolution Nola Taylor Redd

PROFILE 12839 Profile of Susan Brantley Ann Griswold See Inaugural Article on page 12349 in issue 49 of vollume 115

Free online through the PNAS open access option. PNAS u December 18, 2018 u vol. 115 u no. 51 u iii–vii Downloaded by guest on September 26, 2021 COMMENTARIES PHYSICAL SCIENCES 12842 Translation dysregulation in BIOPHYSICS AND COMPUTATIONAL BIOLOGY neurodegenerative disorders Daryl A. Bosco E11894 Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for See companion article on page E11904 Aurora kinase activation states 12845 Malleable folding of coiled-coils regulates Eric W. Lake, Joseph M. Muretta, Andrew R. Thompson, kinesin-3 dimerization Damien M. Rasmussen, Abir Majumdar, Erik B. Faber, Emily F. Jawdat Al-Bassam and Stanley Nithianantham Ruff, David D. Thomas, and Nicholas M. Levinson See companion article on page E11933 E11924 Probing the mechanism of inhibition of amyloid- β – – 12848 Getting a handle on CaV2.2 (N-type) voltage-gated (1 42) induced neurotoxicity by the + Ca2 channels chaperonin GroEL Jo¨rg Striessnig Marielle A. Wa¨lti, Joseph Steiner, Fanjie Meng, Hoi Sung See companion article on page E12043 Chung, John M. Louis, Rodolfo Ghirlando, Vitali Tugarinov, Avindra Nath, and G. Marius Clore 12851 Molecular link between itch and atopic dermatitis 12920 Noninvasive diagnostic imaging using machine- Tiphaine Voisin and Isaac M. Chiu learning analysis of nanoresolution images of See companion article on page E12091 cell surfaces: Detection of bladder cancer I. Sokolov, M. E. Dokukin, V. Kalaparthi, M. Miljkovic, A. Wang, PNAS PLUS J. D. Seigne, P. Grivas, and E. Demidenko 12854 Significance Statements 12926 Spontaneous migration of cellular aggregates from giant keratocytes to running spheroids Brief statements written by the authors about the significance of their Gre´gory Beaune, Carles Blanch-Mercader, Ste´phane papers. Douezan, Julien Dumond, David Gonzalez-Rodriguez, Damien Cuvelier, Thierry Ondarc¸uhu, Pierre Sens, Sylvie Dufour, PERSPECTIVE Michael P. Murrell, and Franc¸oise Brochard-Wyart 13111 Fenestrations control resting-state block of a 12859 Emergent sustainability in open property regimes Mark Moritz, Roy Behnke, Christine M. Beitl, Rebecca Bliege voltage-gated sodium channel Bird, Rafael Morais Chiaravalloti, Julia K. Clark, Stefani A. Tamer M. Gamal El-Din, Michael J. Lenaeus, Ning Zheng, Crabtree, Sean S. Downey, Ian M. Hamilton, Sui Chian Phang, and William A. Catterall Paul Scholte, and James A. Wilson CHEMISTRY 12961 VIPER is a genetically encoded peptide tag for ANTIMICROBIAL RESISTANCE AND THE ROLE OF fluorescence and electron microscopy VACCINES SPECIAL FEATURE Julia K. Doh, Jonathan D. White, Hannah K. Zane, Young Hwan Chang, Claudia S. Lo´pez, Caroline A. Enns, INTRODUCTION and Kimberly E. Beatty 12868 Antimicrobial resistance and the role of vaccines David E. Bloom, Steven Black, David Salisbury, COMPUTER SCIENCES and Rino Rappuoli 13093 A neural data structure for novelty detection Sanjoy Dasgupta, Timothy C. Sheehan, Charles F. Stevens, PERSPECTIVES and Saket Navlakha 12872 Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES whole-genome sequencing 12932 Calditol-linked membrane lipids are required for acid Elizabeth J. Klemm, Vanessa K. Wong, and Gordon Dougan tolerance in Sulfolobus acidocaldarius 12878 Why the evolution of resistance is less of Zhirui Zeng, Xiao-Lei Liu, Jeremy H. Wei, Roger E. Summons, and Paula V. Welander a concern than the evolution of drug resistance David A. Kennedy and Andrew F. Read 12938 Oxygenated Mesoproterozoic lake revealed through magnetic mineralogy 12887 Technologies to address antimicrobial resistance Sarah P. Slotznick, Nicholas L. Swanson-Hysell, Stephen J. Baker, David J. Payne, Rino Rappuoli, and Erik A. Sperling and Ennio De Gregorio 12944 Altimeter-era emergence of the patterns of forced 12896 Impact of existing vaccines in reducing antibiotic sea-level rise in climate models and implications resistance: Primary and secondary effects for the future Keith P. Klugman and Steven Black John T. Fasullo and R. Steven Nerem 12902 Microbiome as a tool and a target in the effort to address antimicrobial resistance ENGINEERING David A. Relman and Marc Lipsitch 12950 Multiresponsive polymeric microstructures 12911 Toward economic evaluation of the value of with encoded predetermined and vaccines and other health technologies in self-regulated deformability addressing AMR Yuxing Yao, James T. Waters, Anna V. Shneidman, Jiaxi Cui, J. P. Sevilla, David E. Bloom, Daniel Cadarette, Mark Jit, Xiaoguang Wang, Nikolaj K. Mandsberg, Shucong Li, Anna C. and Marc Lipsitch Balazs, and Joanna Aizenberg

iv u www.pnas.org Contents Downloaded by guest on September 26, 2021 PHYSICS E11943 Simple yet functional phosphate-loop proteins 12956 Itinerant ferromagnetism of the Pd-terminated polar Maria Luisa Romero Romero, Fan Yang, Yu-Ru Lin, Agnes Toth-Petroczy, Igor N. Berezovsky, Alexander Goncearenco, surface of PdCoO2 Federico Mazzola, Veronika Sunko, Seunghyun Khim, Helge Wen Yang, Alon Wellner, Fanindra Kumar-Deshmukh, Michal Rosner, Pallavi Kushwaha, Oliver J. Clark, Lewis Bawden, Igor Sharon, David Baker, Gabriele Varani, and Dan S. Tawfik Markovic, Timur K. Kim, Moritz Hoesch, Andrew P. Mackenzie, 12979 Emergence of Escherichia coli critically buckled and Phil D. C. King motile helices under stress Trung V. Phan, Ryan J. Morris, Ho Tat Lam, Phuson Hulamm, SOCIAL SCIENCES Matthew E. Black, Julia Bos, and Robert H. Austin 12985 Structure and activity of lipid bilayer within PSYCHOLOGICAL AND COGNITIVE SCIENCES a membrane-protein transporter E12034 Structural and effective brain connectivity underlying Weihua Qiu, Ziao Fu, Guoyan G. Xu, Robert A. Grassucci, Yan biological motion detection Zhang, Joachim Frank, Wayne A. Hendrickson, and Youzhong Guo Arseny A. Sokolov, Peter Zeidman, Michael Erb, Philippe Ryvlin, Karl J. Friston, and Marina A. Pavlova 12991 Excitation-multiplexed multicolor superresolution imaging with fm-STORM and fm-DNA-PAINT Pablo A. Go´mez-Garcı´a, Erik T. Garbacik, Jason J. Otterstrom, BIOLOGICAL SCIENCES Maria F. Garcia-Parajo, and Melike Lakadamyali

BIOCHEMISTRY CELL BIOLOGY E11894 Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for 12997 Isolation and characterization of adrenocortical Aurora kinase activation states progenitors involved in the adaptation to stress Charlotte Steenblock, Maria F. Rubin de Celis, Luis F. Eric W. Lake, Joseph M. Muretta, Andrew R. Thompson, Delgadillo Silva, Verena Pawolski, Ana Brennand, Martin Damien M. Rasmussen, Abir Majumdar, Erik B. Faber, Emily F. Werdermann, Ilona Berger, Alice Santambrogio, Mirko Ruff, David D. Thomas, and Nicholas M. Levinson Peitzsch, Cynthia L. Andoniadou, Andrew V. Schally, E11904 ALS mutations of FUS suppress protein translation and Stefan R. Bornstein and disrupt the regulation of nonsense- 13003 Folate deficiency drives mitotic missegregation of mediated decay the human FRAXA locus Marisa Kamelgarn, Jing Chen, Lisha Kuang, Huan Jin, Victoria A. Bjerregaard, Lorenza Garribba, Cynthia T. Edward J. Kasarskis, and Haining Zhu McMurray, Ian D. Hickson, and Ying Liu See Commentary on page 12842 13009 Microtubule-directed transport of purine metabolons E11914 Cooperative assembly of a four-molecule signaling drives their cytosolic transit to mitochondria complex formed upon T cell antigen Chung Yu Chan, Anthony M. Pedley, Doory Kim, Chenglong receptor activation Xia, Xiaowei Zhuang, and Stephen J. Benkovic Asit Manna, Huaying Zhao, Junya Wada, Lakshmi Balagopalan, 13015 Extensive cellular heterogeneity of X inactivation Harichandra D. Tagad, Ettore Appella, Peter Schuck, and Lawrence E. Samelson revealed by single-cell allele-specific expression in human fibroblasts 12961 VIPER is a genetically encoded peptide tag for Marco Garieri, Georgios Stamoulis, Xavier Blanc, Emilie fluorescence and electron microscopy Falconnet, Pascale Ribaux, Christelle Borel, Federico Santoni, Julia K. Doh, Jonathan D. White, Hannah K. Zane, Young and Stylianos E. Antonarakis Hwan Chang, Claudia S. Lo´pez, Caroline A. Enns, and Kimberly E. Beatty DEVELOPMENTAL BIOLOGY 12967 Ferredoxin-linked flavoenzyme defines a family 13021 Mutation in LBX1/Lbx1 precludes transcription of pyridine nucleotide-independent factor cooperativity and causes congenital thioredoxin reductases hypoventilation in humans and mice Rube´n M. Buey, David Ferna´ndez-Justel, Jose´ M. de Pereda, Luis Rodrigo Hernandez-Miranda, Daniel M. Ibrahim, Jose´ L. Revuelta, Peter Schurmann, Bob B. Buchanan, ¨ Pierre-Louis Ruffault, Madeleine Larrosa, Kira Balueva, Thomas and Monica Balsera Mu¨ller, Willemien de Weerd, Irene Stolte-Dijkstra, 12973 Structural mechanism for HIV-1 TAR loop recognition Robert M. W. Hostra, Jean-Franc¸ois Brunet, Gilles Fortin, by Tat and the super elongation complex Stefan Mundlos, and Carmen Birchmeier Ursula Schulze-Gahmen and James H. Hurley ECOLOGY BIOPHYSICS AND COMPUTATIONAL BIOLOGY E11951 Microbiome interactions shape host fitness E11924 Probing the mechanism of inhibition of amyloid- Alison L. Gould, Vivian Zhang (张维嘉), Lisa Lamberti, Eric W. β(1–42)–induced neurotoxicity by the Jones, Benjamin Obadia, Nikolaos Korasidis, Alex Gavryushkin, chaperonin GroEL Jean M. Carlson, Niko Beerenwinkel, and William B. Ludington Marielle A. Wa¨lti, Joseph Steiner, Fanjie Meng, Hoi Sung 13027 Predicting plant conservation priorities on a Chung, John M. Louis, Rodolfo Ghirlando, Vitali Tugarinov, global scale Avindra Nath, and G. Marius Clore Tara A. Pelletier, Bryan C. Carstens, David C. Tank, Jack E11933 Coiled-coil 1-mediated fastening of the neck and Sullivan, and Anahı´ Espı´ndola motor domains for kinesin-3 autoinhibition 13033 Fipronil pesticide as a suspect in historical mass Jinqi Ren, Shuang Wang, Han Chen, Wenjuan Wang, Lin Huo, mortalities of honey bees and Wei Feng Philippa J. Holder, Ainsley Jones, Charles R. Tyler, See Commentary on page 12845 and James E. Cresswell

Contents PNAS u December 18, 2018 u vol. 115 u no. 51 u v Downloaded by guest on September 26, 2021 GENETICS 13063 Hybrid prevalence estimation: Method to improve E11961 Sae2 antagonizes Rad9 accumulation at DNA intervention coverage estimations double-strand breaks to attenuate checkpoint Caroline Jeffery, Marcello Pagano, Janet Hemingway, signaling and facilitate end resection and Joseph J. Valadez Tai-Yuan Yu, Michael T. Kimble, and Lorraine S. Symington 13069 Knockout of both miR-15/16 loci induces acute E11970 Mother–child transmission of epigenetic information myeloid leukemia by tunable polymorphic imprinting Francesca Lovat, Matteo Fassan, Diana Sacchi, Parvathi Brittany L. Carpenter, Wanding Zhou, Zachary Madaj, Ashley K. Ranganathan, Alexey Palamarchuk, Marius Bill, Malith DeWitt, Jason P. Ross, Kirsten Grønbæk, Gangning Liang, Karunasiri, Pierluigi Gasparini, Giovanni Nigita, Rosario Susan J. Clark, Peter L. Molloy, and Peter A. Jones Distefano, Dario Veneziano, Adrienne M. Dorrance, Ramiro Garzon, and Carlo M. Croce 13039 Biparental Inheritance of Mitochondrial DNA in Humans 13075 FSIP1 regulates autophagy in breast cancer Caigang Liu, Lisha Sun, Jie Yang, Tong Liu, Yongliang Yang, Shiyu Luo, C. Alexander Valencia, Jinglan Zhang, Ni-Chung Se-Min Kim, Xunyan Ou, Yining Wang, Li Sun, Mone Zaidi, Lee, Jesse Slone, Baoheng Gui, Xinjian Wang, Zhuo Li, Sarah Maria I. New, Tony Yuen, and Qiyong Guo Dell, Jenice Brown, Stella Maris Chen, Yin-Hsiu Chien, Wuh-Liang Hwu, Pi-Chuan Fan, Lee-Jun Wong, Paldeep S. Atwal, and Taosheng Huang 13045 Genetic determinants and an epistasis of LILRA3 and E11996 Fiber-associated spirochetes are major agents of HLA-B*52 in Takayasu arteritis hemicellulose degradation in the hindgut of Chikashi Terao, Hajime Yoshifuji, Takayoshi Matsumura, wood-feeding higher termites Taeko K. Naruse, Tomonori Ishii, Yoshikazu Nakaoka, Yohei Gaku Tokuda, Aram Mikaelyan, Chiho Fukui, Yu Kirino, Keitaro Matsuo, Tomoki Origuchi, Masakazu Shimizu, Matsuura, Hirofumi Watanabe, Masahiro Fujishima, Yasuhiro Maejima, Eisuke Amiya, Natsuko Tamura, Takahisa and Andreas Brune Kawaguchi, Meiko Takahashi, Kazuya Setoh, Koichiro Ohmura, E12005 Mycoplasma promotes malignant transformation in Ryu Watanabe, Tetsuya Horita, Tatsuya Atsumi, Mitsuru Matsukura, Tetsuro Miyata, Yuta Kochi, Toshio Suda, Kazuo vivo, and its DnaK, a bacterial chaperon protein, Tanemoto, Akira Meguro, Yukinori Okada, Akiyoshi Ogimoto, has broad oncogenic properties Motohisa Yamamoto, Hiroki Takahashi, Shingo Nakayamada, Davide Zella, Sabrina Curreli, Francesca Benedetti, Kazuyoshi Saito, Masataka Kuwana, Nobuhisa Mizuki, Yasuharu Selvi Krishnan, Fiorenza Cocchi, Olga S. Latinovic, Tabara, Atsuhisa Ueda, Issei Komuro, Akinori Kimura, Mitsuaki Frank Denaro, Fabio Romerio, Muhammad Djavani, Isobe, Tsuneyo Mimori, and Fumihiko Matsuda Man E. Charurat, Joseph L. Bryant, Herve´ Tettelin, and Robert C. Gallo AND INFLAMMATION E12015 Phosphorylation cascade regulates the formation and 13051 Intrinsic TNFR2 signaling in T regulatory cells maturation of rotaviral replication factories provides protection in CNS autoimmunity Jeanette M. Criglar, Ramakrishnan Anish, Liya Hu, Sue E. Crawford, Banumathi Sankaran, B. V. Venkataram Prasad, Kamar-Sulu N. Atretkhany, Ilgiz A. Mufazalov, Josefine Dunst, and Mary K. Estes Anna Kuchmiy, Violetta S. Gogoleva, David Andruszewski, Marina S. Drutskaya, Denise L. Faustman, Marius E12024 MRI demonstrates glutamine antagonist- Schwabenland, Marco Prinz, Andrey A. Kruglov, Ari Waisman, mediated reversal of cerebral malaria and Sergei A. Nedospasov pathology in mice 13057 Basophils trigger emphysema development in a Brittany A. Riggle, Sanhita Sinharay, William murine model of COPD through IL-4–mediated Schreiber-Stainthorp, Jeeva P. Munasinghe, Dragan generation of MMP-12–producing macrophages Maric, Eva Prchalova, Barbara S. Slusher, Jonathan D. Powell, Louis H. Miller, Susan K. Pierce, Sho Shibata, Kensuke Miyake, Tomoya Tateishi, Soichiro and Dima A. Hammoud Yoshikawa, Yoshinori Yamanishi, Yasunari Miyazaki, Naohiko Inase, and Hajime Karasuyama 12932 Calditol-linked membrane lipids are required for acid tolerance in Sulfolobus acidocaldarius MEDICAL SCIENCES Zhirui Zeng, Xiao-Lei Liu, Jeremy H. Wei, Roger E. Summons, E11978 DPYSL3 modulates mitosis, migration, and and Paula V. Welander epithelial-to-mesenchymal transition in 13081 Poplar phyllosphere harbors disparate isoprene- claudin-low breast cancer degrading bacteria Ryoichi Matsunuma, Doug W. Chan, Beom-Jun Kim, Purba Andrew T. Crombie, Nasmille L. Larke-Mejia, Helen Emery, Singh, Airi Han, Alexander B. Saltzman, Chonghui Cheng, Robin Dawson, Jennifer Pratscher, Gordon P. Murphy, Terry J. Jonathan T. Lei, Junkai Wang, Leonardo Roberto da Silva, McGenity, and J. Colin Murrell Ergun Sahin, Mei Leng, Cheng Fan, Charles M. Perou, Anna 13087 Seneca Valley virus attachment and uncoating Malovannaya, and Matthew J. Ellis mediated by its receptor anthrax toxin E11988 Estimating the proportion of bystander selection for receptor 1 antibiotic resistance among potentially pathogenic Lin Cao, Ran Zhang, Tingting Liu, Zixian Sun, Mingxu Hu, Yuna bacterial flora Sun, Lingpeng Cheng, Yu Guo, Sheng Fu, Junjie Hu, Xiangmin Christine Tedijanto, Scott W. Olesen, Yonatan H. Grad, Li, Chengqi Yu, Hanyang Wang, Huanchun Chen, Xueming Li, and Marc Lipsitch Elizabeth E. Fry, David I. Stuart, Ping Qian, Zhiyong Lou, See companion Introduction to the Antimicrobial Resistance and and Zihe Rao the Role of Vaccines Special Feature on page 12868 12920 Noninvasive diagnostic imaging using machine- NEUROSCIENCE learning analysis of nanoresolution images of E12034 Structural and effective brain connectivity underlying cell surfaces: Detection of bladder cancer biological motion detection I. Sokolov, M. E. Dokukin, V. Kalaparthi, M. Miljkovic, A. Wang, Arseny A. Sokolov, Peter Zeidman, Michael Erb, Philippe J. D. Seigne, P. Grivas, and E. Demidenko Ryvlin, Karl J. Friston, and Marina A. Pavlova

vi u www.pnas.org Contents Downloaded by guest on September 26, 2021 E12043 Ablation of α2δ-1 inhibits cell-surface trafficking of PHYSIOLOGY endogenous N-type calcium channels in the pain E12091 Tissue-specific contributions of Tmem79 to atopic pathway in vivo dermatitis and mast cell-mediated histaminergic itch Manuela Nieto-Rostro, Krishma Ramgoolam, Wendy S. Pratt, Joshua J. Emrick, Anubhav Mathur, Jessica Wei, Elena O. Akos Kulik, and Annette C. Dolphin Gracheva, Karsten Gronert, Michael D. Rosenblum, See Commentary on page 12848 and David Julius E12053 Synergistic neuroprotection by coffee components See Commentary on page 12851 + eicosanoyl-5-hydroxytryptamide and caffeine in 13117 Constitutive boost of a K channel via inherent bilayer models of Parkinson’s disease and DLB tension and a unique tension-dependent modality Run Yan, Jie Zhang, Hye-Jin Park, Eun S. Park, Stephanie Oh, Masayuki Iwamoto (岩本真幸) and Shigetoshi Oiki (老木成稔) Haiyan Zheng, Eunsung Junn, Michael Voronkov, Jeffry B. Stock, and M. Maral Mouradian PLANT BIOLOGY E12063 Inflammation in the hippocampus affects IGF1 E12101 Low-oxygen response is triggered by an ATP- receptor signaling and contributes to neurological dependent shift in oleoyl-CoA in Arabidopsis sequelae in rheumatoid arthritis Romy R. Schmidt, Martin Fulda, Melanie V. Paul, Max Karin M. E. Andersson, Caroline Wase´n, Lina Juzokaite, Anders, Frederic Plum, Daniel A. Weits, Monika Kosmacz, Lovisa Leifsdottir, Malin C. Erlandsson, Sofia T. Tony R. Larson, Ian A. Graham, Gerrit T. S. Beemster, Silfverswa¨rd, Anna Stokowska, Marcela Pekna, Milos Pekny, Francesco Licausi, Peter Geigenberger, Jos H. Schippers, Kjell Olmarker, Rolf A. Heckemann, Marie Kalm, and Joost T. van Dongen and Maria I. Bokarewa E12111 A unique ferredoxin acts as a player in the low-iron E12073 Two distinct profiles of fMRI and neurophysiological response of photosynthetic organisms activity elicited by acetylcholine in visual cortex Michael Schorsch, Manuela Kramer, Tatjana Goss, Marion Daniel Zaldivar, Alexander Rauch, Nikos K. Logothetis, Eisenhut, Nigel Robinson, Deenah Osman, Annegret Wilde, and Jozien Goense Shamaila Sadaf, Hendrik Bru¨ckler, Lorenz Walder, Renate E12083 GABA release selectively regulates synapse Scheibe, Toshiharu Hase, and Guy T. Hanke development at distinct inputs on direction- 13123 Leucine-rich repeat extensin proteins regulate plant selective retinal ganglion cells salt tolerance in Arabidopsis Adam Bleckert, Chi Zhang, Maxwell H. Turner, David Koren, Chunzhao Zhao, Omar Zayed, Zheping Yu, Wei Jiang, Peipei David M. Berson, Silvia J. H. Park, Jonathan B. Demb, Fred Zhu, Chuan-Chih Hsu, Lingrui Zhang, W. Andy Tao, Rosa Rieke, Wei Wei, and Rachel O. Wong Lozano-Dura´n, and Jian-Kang Zhu 13093 A neural data structure for novelty detection PSYCHOLOGICAL AND COGNITIVE SCIENCES Sanjoy Dasgupta, Timothy C. Sheehan, Charles F. Stevens, and Saket Navlakha 13129 Inherent auditory skills rather than formal music training shape the neural encoding of speech 13099 Removal of clock gene Bmal1 from the retina affects Kelsey Mankel and Gavin M. Bidelman retinal development and accelerates cone photoreceptor degeneration during aging SUSTAINABILITY SCIENCE Kenkichi Baba, Ilaria Piano, Polina Lyuboslavsky, Micah A. Chrenek, Jana T. Sellers, Shuo Zhang, Claudia Gargini, Li He, 13027 Predicting plant conservation priorities on a Gianluca Tosini, and P. Michael Iuvone global scale 13105 Genetic recovery of ErbB4 in adulthood partially Tara A. Pelletier, Bryan C. Carstens, David C. Tank, Jack Sullivan, and Anahı´ Espı´ndola restores brain functions in null mice Hongsheng Wang, Fang Liu, Wenbing Chen, Xiangdong Sun, Wanpeng Cui, Zhaoqi Dong, Kai Zhao, Hongsheng SI CORRECTION (ONLINE ONLY) Zhang, Haiwen Li, Guanglin Xing, Erkang Fei, Bing-Xing Pan, Bao-Ming Li, Wen-Cheng Xiong, and Lin Mei NEUROSCIENCE E12121 External light activates hair follicle stem cells through PHARMACOLOGY eyes via an ipRGC–SCN–sympathetic neural pathway 13111 Fenestrations control resting-state block of a Sabrina Mai-Yi Fan, Yi-Ting Chang, Chih-Lung Chen, Wei-Hung voltage-gated sodium channel Wang, Ming-Kai Pan, Wen-Pin Chen, Wen-Yen Huang, Zijian Tamer M. Gamal El-Din, Michael J. Lenaeus, Ning Zheng, Xu, Hai-En Huang, Ting Chen, Maksim V. Plikus, Shih-Kuo and William A. Catterall Chen, and Sung-Jan Lin

Contents PNAS u December 18, 2018 u vol. 115 u no. 51 u vii Downloaded by guest on September 26, 2021