International Symposium on Engineering Stimuli- Responsive Nanomaterials for Drug Delivery 26 Oct, 2017

Organized by Sponsored by Dr Li Dak - Sum Research Centre, Biomedical Engineering and Nanotechnology, The University of Hong Kong - Karolinska Institutet Strategic Research Theme, Collaboration in Regenerative Medicine The University of Hong Kong

Symposium Programme

Prof. LEUNG Suet Yi 10:50-11:00 Welcome and Opening Remarks The University of Hong Kong Session Chair: Dr. YEUNG Kelvin, The University of Hong Kong Nanoscale Biomaterials for Regulating Dr. BIAN Liming 11:00-11:35 Stem Cell Behaviors and Promoting In-situ The Chinese University of Hong Kong Tissue Regeneration Combination of Nanomedicine and Prof. Xuesi 11:35-12:10 Vascular Disrupting Agent for Cancer Institute of Applied Chemistry Therapy Chinese Academy of Sciences Tumor Microenvironment-Targeted Prof. WANG Jun 12:10-12:45 Nanomedicine for Enhanced Cancer South China University of Technology Therapy 12:45-14:00 Lunch Break Session Chair: Dr. SHUM Anderson, The University of Hong Kong New Theranostics for Early Detection and Prof. WANG Min 14:00-14:35 Effective Treatment of Cancer The University of Hong Kong Stimuli-Responsive Micro/ Dr. XU Chenjie 14:35-15:10 Nanotechnologies for Theranosis in Tissue Nanyang Technological University Engineering Tumor Microenvironment-Responsive Dr. GE Zhishen 15:10-15:45 Block Copolymers for Drug Delivery to University of Science and Technology of Overcome Physiological Barriers China 15:45-16:15 Tea Break Session Chair: Dr. WANG Weiping, The University of Hong Kong Exploring Stimulus-Triggered Shifting of Prof. ZHAO Yue 16:15–16:50 Critical Solution Temperature for Polymer Université de Sherbrooke Micelle Disruption Dr. GU Zhen Bio-responsive Drug Delivery by Artificial 16:50–17:25 University of North Carolina at Chapel Hill Cells and Real Cells & North Carolina State University Bioresponsive RNA Nanomedicines for Dr. SHI Jinjun 17:25–18:00 Cancer Therapy Harvard Medical School Prof. TAM Paul 18:00–18:15 Closing Remarks The University of Hong Kong

Symposium Information

Date: 26 Oct, 2017 (Thursday)

Venue: Cheung Kung Hai Lecture Theatre 1, William M.W. Mong Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong Official Language: English Symposium Chair: Dr. WANG Weiping Symposium Secretariats: Dr. LEON Thomas, Miss MAK Jessica Graphic Designer: Miss LI Yafei Symposium Helpers: Dr. LV Wen, Miss ZHANG Yaming, Miss LI Yafei, Miss DU Zhanfeng, Mr. TIAN Fujia Organized by: Dr. Li Dak-Sum Research Centre, The University of Hong Kong – Karolinska Institutet Collaboration in Regenerative Medicine Sponsored by: Biomedical Engineering and Nanotechnology, Strategic Research Theme, The University of Hong Kong

For more information, please scan the QR code or visit the website:

http://wanglab.org/symposium2017/

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Nanoscale Biomaterials for Regulating Stem Cell Behaviors and Promoting In- situ Tissue Regeneration Dr. BIAN Liming Assistant Professor Department of Biomedical Engineering The Chinese University of Hong Kong Email: [email protected]

Dr. Bian received his B.Sc. and M.Sc. from the National University of Singapore in 2002 and 2004, respectively. He completed his Ph.D. study in Biomedical Engineering under the advisory of Dr. Clark T. Hung and Dr. Gerard A. Ateshian at Columbia University in 2009. Then Dr. Bian completed his postdoctoral training under the advisory of Dr. Jason A. Burdick at the Polymeric Biomaterial Laboratory in the Department of Bioengineering, the University of Pennsylvania from 2009 to 2012. Dr. Bian joined The Chinese University of Hong Kong as an assistant professor in 2012. His research focuses on the development of novel multiscale biomaterials for regenerative medicine. Dr. Bian is also an affiliated member of the Orthopedic Research Society, American Chemical Society and Society for Biomaterials.

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Combination of Nanomedicine and Vascular Disrupting Agent for Cancer Therapy Prof. CHEN Xuesi Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Email: [email protected]

Prof. Chen received his B.Sc. from the Chemistry Department of University in 1982 and M.Sc. from Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS) in 1988. He obtained his Ph.D. from Waseda University Japan in 1997. He had his postdoctoral training at the University of Pennsylvania from 1997 to 1999. Prof. Chen has worked in CIAC since 1999 as a full professor. Currently he is working in the Key Laboratory of Polymer Ecomaterials of CAS in CIAC. His research interests include synthesis of Schiff Base catalyst for ROP of lactides, preparation of biodegradable polymers with functional properties, development of biodegradable polymers for medical applications such as bone fixation and bone repair by tissue engineering scaffolds, antiadhesion membrane of tendon and intestine, anticancer nanocarriers for gene or drug delivery, bioimaging, and industrialization of polylactide as green plastics. He has published over 700 peer-reviewed papers (H-index > 80 based on Google Scholar). He is one of the board members of the journals of Acta Biomateria, Advanced Healthcare Materials, Biomacromolecules, Journal of Controlled Release and Macromolecular Bioscience.

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Tumor Microenvironment-Targeted Nanomedicine for Enhanced Cancer Therapy Prof. WANG Jun Institutes for Life Sciences, School of Medicine South China University of Technology Email: [email protected]

Prof. Wang received his B.Sc. in Chemistry and Cell Biology in 1993 and Ph.D. in Polymer Chemistry and Physics in 1999 from Wuhan University, China. From 1999 to 2004, he worked as a postdoctoral fellow at Johns Hopkins Singapore and Johns Hopkins School of Medicine. He joined University of Science and Technology of China as a full professor in 2004, and moved to South China University of Technology in 2016. He was awarded by the Hundred Talent Program of the Chinese Academy of Sciences in 2005, “Outstanding Young Scholar Award” of the National Science Foundation of China in 2011 and Fellow of Royal Society of Chemistry in 2016. He received the Second Class Prize of National Natural Science Award of China in 2015. His main research focus is developing biomaterials for drug delivery. He has published more than 150 peer-reviewed papers with total over 7500 citations. Currently, he serves as an associate editor of Biomaterials Science, and the editorial board member of Acta Biomaterialia and ChemNanoMat.

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New Theranostics for Early Detection and Effective Treatment of Cancer

Prof. WANG Min Department of Mechanical Engineering The University of Hong Kong Email: [email protected]

Prof. Wang earned his B.Sc. and Ph.D. at Shanghai Jiao Tong University and University of London, respectively. He has worked in universities in the UK (1991-1997), Singapore (1997- 2002). He has been a Guest or Adjunct Professor of universities in mainland China (Shanghai Jiao Tong University, Zhejiang University, etc.). Now he is a full professor and currently Programme Director of the Medical Engineering Programme at The University of Hong Kong. Also, he is an elected fellow of professional societies in the UK, HK, USA and internationally (FIMMM, 2001; FIMechE, 2007; FHKIE, 2010; FBSE, 2011; FAIMBE, 2012; WAC Academician, 2013). Since 1991, he has been conducting research in the biomaterials and tissue engineering fields. He has authored a large number of research papers as well as many book chapters. Prof. Wang has been the Series Editor of Springer Series in Biomaterials Science and Engineering, Editor, Associate Editor or Regional Editor of several international journals (Materials Letters, Nano LIFE, Medical & Biological Engineering & Computing, etc.), and member of Editorial Boards of 18 international, printed journals. He was Chairman of the Biomedical Division of HKIE. He has been an elected Council Member of Chinese Society for Biomaterials, Hong Kong Institution of Engineers (HKIE), Asian Biomaterials Federation World Association for Chinese Biomedical Engineers, and so on. 5

Stimuli-Responsive Micro/ Nanotechnologies for Theranosis in Tissue Engineering Dr. XU Chenjie Assistant Professor School of Chemical and Biomedical Engineering Nanyang Technological University Email: [email protected]

Dr. Xu received his B.Sc. from Nanjing University (2002, China), and M.Phil. from The Hong Kong University of Science and Technology (2004). After one-year internship at Stanford University (2005), he continued his Ph.D. study at Brown University (RI, 2005-2009). Dr. Xu was awarded Vince Wernig Fellowship (2007-2008), Joukowsky Outstanding Dissertation Prize (2009), and Potter Prize for Outstanding Doctoral Thesis (2009). From 2009-2012, he was a research associate in the Harvard-MIT Health Sciences and Technology (HST) Program and Harvard medical school. He joined Nanyang Technological University as an Assistant Professor in August 2012. He has published over 90 papers in total and edited five book chapters. He has contributed significantly to the field of nanomedicine or medical applications of nanomaterials such as molecular imaging and drug delivery. His publications have a total ISI citation of over 6000 and an H-index of 29. He also holds several patents in nanomaterials for molecular imaging and drug delivery.

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Tumor Microenvironment-Responsive Block Copolymers for Drug Delivery to Overcome Physiological Barriers Dr. GE Zhishen Associate Professor Department of Polymer Science and Engineering University of Science and Technology of China E-mail: [email protected]

Dr. Ge received his B.Sc. from Anhui University in 2004, majoring in applied chemistry. After obtaining his Ph.D. in 2009 at University of Science and Technology of China under the supervision of Prof. Shiyong Liu, he worked as a postdoctoral fellow with Prof. Peter X. Ma and Prof. Kazunori Kataoka at University of Michigan and University of Tokyo, respectively, from 2009 to 2011. Since 2012, he has worked in the Department of Polymer Science and Engineering, University of Science and Technology of China as an associate professor. He has first-authored major polymer and biomaterial journals including J. Am. Chem. Soc., Angew. Chem. Int. Ed., and Biomaterials. His current research interests include designing and fabrication of biocompatible functional polymers, self-assembly of stimuli-responsive polymers, applications of biopolymers in drug/gene delivery as well as imaging, and synthesis of biocompatible hydrogels and their applications in tissue engineering.

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Exploring Stimulus-Triggered Shifting of Critical Solution Temperature for Polymer Micelle Disruption Prof. ZHAO Yue Département de chimie Université de Sherbrooke E-mail : [email protected]

Prof. Zhao received his B.Sc. in 1982 from Chengdu University of Science and Technology (now Sichuan University, China). He went to France in 1983 for graduate studies at the École Supérieure de Physique et de Chimie Industrielles de Paris (ESPCI). After obtaining his Ph.D. in 1987, he went to Canada for postdoctoral studies at the Université Laval. In 1991, he joined the Chemistry Department of the Université de Sherbrooke and has been a full professor since 2000. Prof. Zhao’s main research interest focuses on self-assembled, nanostructured and stimuli- responsive polymers and liquid crystalline materials. He has published near 200 papers in primary journals and edited a book on azobenzene-containing polymers and liquid crystals (Wiley, 2009). Prof. Zhao was awarded “Chang Jiang Scholar Chair Professor” by the Ministry of Education of China (Sichuan University, 2007-2010). He is the 2013 recipient of the Macromolecular Science and Engineering Award of the Chemical Institute of Canada (CIC) and was elected CIC Fellow in 2014.

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Bio-responsive Drug Delivery by Artificial Cells and Real Cells Dr. GU Zhen Associate Professor University of North Carolina at Chapel Hill & North Carolina State University Email: [email protected]

Dr. Gu received his B.Sc. and M.Sc from Nanjing University. In 2010, he obtained his Ph.D. under Prof. Yi Tang at the University of California, Los Angeles, in the Department of Chemical and Biomolecular Engineering. He was a postdoctoral associate working with Prof. Robert Langer at MIT and Harvard Medical School during 2010 to 2012. He is currently an Associate Professor at the University of North Carolina at Chapel Hill & North Carolina State University. He also holds joint positions in the Eshelman School of Pharmacy and Department of Medicine at UNC. His group studies controlled drug delivery, bio-inspired materials and nanobiotechnology. He has published over 100 research papers and applied over 40 patents. He is a co-founder of two startup companies. His invention-“Smart Insulin Patch” was featured by Nature and selected as one of the top 10 research images in 2015 by Science. Dr. Gu is the recipient of the Sloan Research Fellowship (2016), Young Investigator Award in Controlled Release Society (CRS, 2017), Alcoa Foundation Research Achievement Award (2017), Pathway Award of the American Diabetes Association (ADA, 2015) and Young Innovator Award in Cellular and Molecular Engineering of the Biomedical Engineering Society (BMES, 2015). MIT Technology Review listed him in 2015 as one of the global top innovators under the age of 35 (TR35). 9

Bioresponsive RNA Nanomedicines for Cancer Therapy Dr. SHI Jinjun, Assistant Professor Brigham and Women's Hospital Harvard Medical School Email: [email protected]

Dr. Shi obtained his B.Sc. from Tsinghua University and his Ph.D. in Chemistry from Texas A&M University. He received his postdoctoral training at Harvard Medical School with Dr. Omid C. Farokhzad, and at Massachusetts Institute of Technology with Dr. Robert Langer. Dr. Shi currently holds an academic appointment of Assistant Professor at Harvard Medical School. He is also a faculty member in the Center for Nanomedicine at Brigham and Women’s Hospital, and a research affiliate at Harvard-MIT Division of Health Sciences and Technology. His research laboratory focuses on a highly interdisciplinary combination of nanotechnology, biomaterials, drug delivery, and immunotherapy. He has developed various nanoparticle platforms for the delivery of small molecules, peptides, proteins, and RNAs. In particular, the immunonanotherapeutic technologies developed by him and his colleagues are now in clinical trials for the treatment of inflammatory diseases (by Selecta Biosciences). He has published 46 peer-reviewed papers and holds >40 patents/patent applications worldwide. He has also received many awards, such as the K99/R00 Career Transition Award from National Institutes of Health, and the Movember Challenge Award and the Young Investigator Award from Prostate Cancer Foundation.

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Address: 5/F The Hong Kong Jockey Club Building for Interdisciplinary Research, Phone: +852 2831 5391 5 Sassoon Road, Email: [email protected] The University of Hong Kong Website: http://www.ldsrc.hku.hk/ Pokfulam, Hong Kong