Supplementary Table S1

Gene list Number Analysis type Functional category Category ID P-value Fold Number Number Number of Percent of Percent of Gene names Gene descriptions of genes description enrich of of genes genes category genes tested ment affected in expected tested genes category by chance

desensitization of G protein-coupled Biological receptor signaling Over-expressed 24 AEL 116 process pathway by arrestin GO:0002032 8.00E-05 Inf 2 2 0.02 100.0% 1.7% Arr1,Arr2 Arrestin 1,Arrestin 2 Biological negative adaptation of Over-expressed 24 AEL 116 process signaling pathway GO:0022401 8.00E-05 Inf 2 2 0.02 100.0% 1.7% Arr1,Arr2 Arrestin 1,Arrestin 2 negative regulation of G protein-coupled Biological receptor signaling Over-expressed 24 AEL 116 process pathway GO:0045744 8.00E-05 Inf 2 2 0.02 100.0% 1.7% Arr1,Arr2 Arrestin 1,Arrestin 2 Arrestin 1,Arrestin Biological cellular response to Arr1,Arr2,Rh5 2,Rhodopsin Over-expressed 24 AEL 116 process light stimulus GO:0071482 2.00E-04 16.01 4 33 0.3 12.1% 3.4% ,Rh6 5,Rhodopsin 6 Arrestin 1,Arrestin Biological cellular response to Arr1,Arr2,Ku8 2,Ku80,Rhodopsin Over-expressed 24 AEL 116 process abiotic stimulus GO:0071214 0.00021 10.48 5 61 0.55 8.2% 4.3% 0,Rh5,Rh6 5,Rhodopsin 6

Arrestin 1,Arrestin 2,ATP citrate lyase,Glucocerebrosida se 1a,Ku80,magro,meiotic Arr1,Arr2,ATP recombination CL,CG12896,C 11,Neural G6908,Gba1a Lazarillo,uncharacterize ,Ku80,mag,mr d protein,Vacuolar H[+] Biological e11,NLaz,ver, ATPase 100kD subunit Over-expressed 24 AEL 116 process homeostatic process GO:0042592 0.00034 3.66 12 421 3.78 2.9% 10.3% Vha100-4 4,verrocchio Biological Crystallin,Rhodopsin Over-expressed 24 AEL 116 process visual perception GO:0007601 0.00043 24.58 3 17 0.15 17.6% 2.6% Crys,Rh5,Rh6 5,Rhodopsin 6 Arrestin 1,Arrestin Biological Arr1,Arr2,Rh5 2,Rhodopsin Over-expressed 24 AEL 116 process phototransduction GO:0007602 0.00074 11.04 4 46 0.41 8.7% 3.4% ,Rh6 5,Rhodopsin 6 Biological metarhodopsin Over-expressed 24 AEL 116 process inactivation GO:0016060 0.00078 75.53 2 5 0.04 40.0% 1.7% Arr1,Arr2 Arrestin 1,Arrestin 2 Molecular Over-expressed 24 AEL 116 function opsin binding GO:0002046 8.90E-05 Inf 2 2 0.02 100.0% 1.7% Arr1,Arr2 Arrestin 1,Arrestin 2 Molecular G protein-coupled Rhodopsin 5,Rhodopsin Over-expressed 24 AEL 116 function photoreceptor activity GO:0008020 0.00027 214.21 2 3 0.03 66.7% 1.7% Rh5,Rh6 6 Arrestin 1,Arrestin Cellular Arr1,Arr2,Rh5 2,Rhodopsin Over-expressed 24 AEL 116 component rhabdomere GO:0016028 6.60E-05 21.93 4 30 0.22 13.3% 3.4% ,Rh6 5,Rhodopsin 6

Hemolectin,Niemann- Pick type C-2g,Niemann- Under-expressed 24 Biological hemolymph Hml,Npc2g,N Pick type C- AEL 133 process coagulation GO:0042381 2.30E-06 68.92 4 9 0.11 44.4% 3.0% pc2h,PPO1 2h,Prophenoloxidase 1

Hemolectin,Niemann- Pick type C-2g,Niemann- Under-expressed 24 Biological regulation of body Hml,Npc2g,N Pick type C- AEL 133 process fluid levels GO:0050878 8.00E-05 21.51 4 20 0.24 20.0% 3.0% pc2h,PPO1 2h,Prophenoloxidase 1 Niemann-Pick type C- 2d,Niemann-Pick type C- Under-expressed 24 Biological intracellular Npc2d,Npc2g, 2g,Niemann-Pick type C- AEL 133 process cholesterol transport GO:0032367 0.00013 42.63 3 9 0.11 33.3% 2.3% Npc2h 2h Niemann-Pick type C- 2d,Niemann-Pick type C- Under-expressed 24 Biological intracellular lipid Npc2d,Npc2g, 2g,Niemann-Pick type C- AEL 133 process transport GO:0032365 0.00025 31.97 3 11 0.13 27.3% 2.3% Npc2h 2h prolyl-4-hydroxylase- peptidyl-proline CG31371,CG9 alpha Under-expressed 24 Biological hydroxylation to 4- 698,PH4alpha MP,uncharacterized AEL 133 process hydroxy-L-proline GO:0018401 0.00034 28.41 3 12 0.14 25.0% 2.3% MP protein

CG11842,CG1 Jonah 65Ai,Jonah 2951,CG1671 65Aii,Jonah 66Ci,Jonah 0,CG18477,C 66Cii,Jonah 74E,kelch G31780,CG34 like family member 437,CG4017,C 10,Ribonucleoside G4408,CG491 diphosphate reductase 4,Jon65Ai,Jon small subunit,Serine 65Aii,Jon66Ci, protease homolog Jon66Cii,Jon7 93,thetaTrypsin,Ubiquit 4E,klhl10,Rnr in carboxy-terminal Under-expressed 24 Biological S,SPH93,theta hydrolase,uncharacteriz AEL 133 process proteolysis GO:0006508 4.00E-04 2.68 19 684 8.16 2.8% 14.3% Try,Uch ed protein prolyl-4-hydroxylase- CG31371,CG9 alpha Under-expressed 24 Biological 698,PH4alpha MP,uncharacterized AEL 133 process protein hydroxylation GO:0018126 0.00083 19.66 3 16 0.19 18.8% 2.3% MP protein CG11842,CG1 2951,CG1671 0,CG31780,C G34437,CG49 Jonah 65Ai,Jonah 14,Jon65Ai,Jo 65Aii,Jonah 66Ci,Jonah n65Aii,Jon66C 66Cii,Jonah 74E,Serine i,Jon66Cii,Jon protease homolog Under-expressed 24 Molecular serine-type 74E,SPH93,th 93,thetaTrypsin,unchar AEL 133 function endopeptidase activity GO:0004252 9.20E-09 9.63 13 146 1.67 8.9% 9.8% etaTry acterized protein CG11842,CG1 2951,CG1671 0,CG31780,C G34437,CG49 Jonah 65Ai,Jonah 14,Jon65Ai,Jo 65Aii,Jonah 66Ci,Jonah n65Aii,Jon66C 66Cii,Jonah 74E,Serine i,Jon66Cii,Jon protease homolog Under-expressed 24 Molecular serine hydrolase 74E,SPH93,th 93,thetaTrypsin,unchar AEL 133 function activity GO:0017171 4.70E-08 8.3 13 167 1.91 7.8% 9.8% etaTry acterized protein

CG11842,CG1 2951,CG1671 0,CG31780,C G34437,CG40 Jonah 65Ai,Jonah 17,CG4408,C 65Aii,Jonah 66Ci,Jonah G4914,Jon65 66Cii,Jonah 74E,Serine Ai,Jon65Aii,Jo protease homolog n66Ci,Jon66Ci 93,thetaTrypsin,Ubiquit peptidase activity, i,Jon74E,SPH9 in carboxy-terminal Under-expressed 24 Molecular acting on L-amino acid 3,thetaTry,Uc hydrolase,uncharacteriz AEL 133 function peptides GO:0070011 7.60E-06 4.25 16 390 4.47 4.1% 12.0% h ed protein oxidoreductase activity, acting on diphenols and related Under-expressed 24 Molecular substances as donors, Prophenoloxidase AEL 133 function oxygen as acceptor GO:0016682 0.00013 Inf 2 2 0.02 100.0% 1.5% PPO1,PPO2 1,Prophenoloxidase 2 L-DOPA Under-expressed 24 Molecular monooxygenase Prophenoloxidase AEL 133 function activity GO:0036263 0.00013 Inf 2 2 0.02 100.0% 1.5% PPO1,PPO2 1,Prophenoloxidase 2 dopamine Under-expressed 24 Molecular monooxygenase Prophenoloxidase AEL 133 function activity GO:0036264 0.00013 Inf 2 2 0.02 100.0% 1.5% PPO1,PPO2 1,Prophenoloxidase 2 oxidoreductase activity, acting on prolyl-4-hydroxylase- single donors with CG31371,CG6 alpha Under-expressed 24 Molecular incorporation of 910,CG9698,P MP,uncharacterized AEL 133 function molecular oxygen GO:0016701 0.00014 17.97 4 24 0.28 16.7% 3.0% H4alphaMP protein prolyl-4-hydroxylase- CG31371,CG9 alpha Under-expressed 24 Molecular procollagen-proline 4- 698,PH4alpha MP,uncharacterized AEL 133 function dioxygenase activity GO:0004656 0.00023 33.38 3 11 0.13 27.3% 2.3% MP protein prolyl-4-hydroxylase- CG31371,CG9 alpha Under-expressed 24 Molecular peptidyl-proline 698,PH4alpha MP,uncharacterized AEL 133 function dioxygenase activity GO:0031543 6.00E-04 22.24 3 15 0.17 20.0% 2.3% MP protein Niemann-Pick type C- 2d,Niemann-Pick type C- Under-expressed 24 Molecular Npc2d,Npc2g, 2g,Niemann-Pick type C- AEL 133 function sterol binding GO:0032934 0.00073 20.53 3 16 0.18 18.8% 2.3% Npc2h 2h 2mit,5- 2mit,5- HT1A,Ac78C,A hydroxytryptamine lk,alpha- (serotonin) receptor Est1,amn,Arr 1A,Adenylyl cyclase 1,Arr2,Ca- 78C,alpha-Esterase- alpha1T,cac,C 1,amnesiac,Anaplastic G2698,CG313 lymphoma 00,CG34371,C kinase,Arrestin G4025,CG777 1,Arrestin 2,Ca[2+]- 8,CG9447,CG channel protein 9492,CheB42c alpha[[1]] subunit ,chico,Desi,Dh T,cacophony,Chemosen c93AB,dia,dlp sory protein B ,Dop1R1,Dop2 42c,chico,dally- R,dpr11,dpr12 like,defective proboscis ,dpr16,dpr18, extension response dpr2,dpr20,dp 11,defective proboscis r4,dpr5,dpr6,d extension response rl,dysc,eag,Et 12,defective proboscis s96B,FoxP,fut extension response sch,GluClalph 16,defective proboscis a,Gr33a,Gr39 extension response a,Gr94a,Grd,h 18,defective proboscis iw,iav,inaC,Ir2 extension response Biological nervous system 1a,Ir25a,Ir76b 2,defective proboscis Over-expressed 48 AEL 1301 process process GO:0050877 2.40E-09 2.23 86 410 45.67 21.0% 6.6% ,meru,mGluR, extension response amn,Arr1,Atg amnesiac,Arrestin 9,bun,Ca- 1,Autophagy-related alpha1T,cac,C 9,bunched,Ca[2+]- CKLR- channel protein 17D1,CCKLR- alpha[[1]] subunit 17D3,CG1036 T,cacophony,Cholecysto 2,CG10702,C kinin-like receptor at G13995,CG16 17D1,Cholecystokinin- 57,CG16721,C like receptor at G32547,CG32 17D3,Corepressor of 683,CG34393, Pangolin,Cyclic CG42366,CG4 nucleotide-gated ion 2450,CG4254 channel-like,Derailed 1,CG5160,CG 2,dimmed,Diuretic 5937,CG5953, hormone 44 receptor CG9098,Cngl, 1,DJ-1alpha,Dopamine Coop,Dh44- 2-like R1,dimm,DJ- receptor,earmuff,erect 1alpha,Dop2R wing,ether a go- ,Drl- go,Follistatin,germ cell- 2,eag,erm,ew less,Glycoprotein g,Fs,GABA-B- hormone beta R3,Gadd45,gc 5,Growth arrest and l,Gpb5,Gyc32 DNA damage-inducible Biological E,hiw,IMPPP,I 45,Guanyl cyclase at Over-expressed 48 AEL 1301 process signaling GO:0023052 9.60E-08 1.55 237 1578 175.78 15.0% 18.2% r21a,Ir25a,lb 32E,highwire,Immune Adenylyl cyclase 78C,Arrestin 1,Arrestin 2,Chemosensory protein B 42c,defective proboscis extension response 11,defective proboscis extension response 12,defective proboscis extension response 16,defective proboscis extension response 18,defective Ac78C,Arr1,Ar proboscis extension r2,CheB42c,D response 2,defective esi,dpr11,dpr proboscis extension 12,dpr16,dpr1 response 20,defective 8,dpr2,dpr20, proboscis extension dpr4,dpr5,dpr response 4,defective 6,eag,Gr33a, proboscis extension Gr39a,Gr94a,i response 5,defective av,Ir21a,Ir25a proboscis extension ,Ir76b,Obp18a response ,Obp49a,Obp 6,Desiccate,ether a go- 56d,Obp56h, go,Gustatory receptor Biological sensory perception of Or82a,rdgB,S 33a,Gustatory receptor Over-expressed 48 AEL 1301 process chemical stimulus GO:0007606 1.80E-07 3.64 29 94 10.47 30.9% 2.2% h 39a,Gustatory receptor amn,Arr1,Atg amnesiac,Arrestin 8a,bun,Ca- 1,Autophagy-related alpha1T,cac,C 8a,bunched,Ca[2+]- CKLR- channel protein 17D1,CCKLR- alpha[[1]] subunit 17D3,CG1036 T,cacophony,Cholecysto 2,CG10702,C kinin-like receptor at G13995,CG16 17D1,Cholecystokinin- 57,CG16721,C like receptor at G32547,CG32 17D3,Corepressor of 683,CG34393, Pangolin,Cyclic CG42366,CG4 nucleotide-gated ion 2450,CG4254 channel-like,Derailed 1,CG5160,CG 2,dimmed,Diuretic 5937,CG5953, hormone 44 receptor CG9098,Cngl, 1,DJ-1alpha,Dopamine Coop,Dh44- 2-like R1,dimm,DJ- receptor,earmuff,erect 1alpha,Dop2R wing,ether a go- ,Drl- go,Follistatin,germ cell- 2,eag,erm,ew less,Glycoprotein g,Fs,GABA-B- hormone beta R3,Gadd45,gc 5,Growth arrest and l,Gpb5,Gyc32 DNA damage-inducible Biological E,hiw,IMPPP,I 45,Guanyl cyclase at Over-expressed 48 AEL 1301 process cell communication GO:0007154 1.10E-06 1.5 223 1531 168.42 14.6% 17.1% r21a,Ir25a,lb 32E,highwire,Immune 5-HT1A,5- 5-hydroxytryptamine HT2B,Ac78C,a (serotonin) receptor mn,Arr1,Arr2, 1A,5- CCHa1,CCKLR- hydroxytryptamine 17D1,CCKLR- (serotonin) receptor 17D3,CG1357 2B,Adenylyl cyclase 9,CG13995,C 78C,amnesiac,Arrestin G32547,CG34 1,Arrestin 2,CCHamide- 384,CG42450, 1,Cholecystokinin-like CG43373,CG4 receptor at 3795,CG7497, 17D1,Cholecystokinin- CNMaR,Dh44- like receptor at R1,Dop1R1,D 17D3,CNMamide op2R,Ets96B,f Receptor,Diuretic oxo,GABA-B- hormone 44 receptor R3,Galphaf,G 1,Dopamine 1-like beta76C,inaC, receptor 1,Dopamine 2- Lgr3,mGluR, like MsR1,mthl8,n receptor,Ets96B,forkhe inaC,NPFR,Np ad box, sub-group O,G lp4,Oamb,Oct protein alpha f beta1R,Octbe subunit,G protein beta- ta3R,PK1- subunit G protein-coupled R,PK2- 76C,inactivation no Biological receptor signaling R2,Proc,rdgB, afterpotential Over-expressed 48 AEL 1301 process pathway GO:0007186 2.80E-06 2.55 39 165 18.26 23.6% 3.0% rdgC,Rh5,Rh6, C,Leucine-rich repeat-

Attacin-A,Attacin- B,Attacin-C,Attacin- D,Cecropin A1,Cecropin A2,defense repressor 1,Diptericin B,Drosocin,Drosomycin, AttA,AttB,Att Immune induced C,AttD,CecA1, molecule 3,Immune CecA2,dnr1,D induced molecule ptB,Dro,Drs,I prepropeptide,Metchni M3,IMPPP,Mt kowin,Peptidoglycan Biological antibacterial humoral k,PGRP- recognition protein Over-expressed 48 AEL 1301 process response GO:0019731 3.40E-06 5.18 16 41 4.57 39.0% 1.2% LF,Rel,Thor LF,Relish,thor Arrestin 1,Arrestin 2,cacophony,Ceramide kinase,dally-like,G protein beta-subunit 76C,inactivation no afterpotential C,lazaro,neither inactivation nor afterpotential C,Phosphatidylinositol 4- phosphate 5-kinase at 59B,prolonged depolarization afterpotential (PDA) is Arr1,Arr2,cac, not apparent,retinal Cerk,dlp,Gbet degeneration B,retinal a76C,inaC,laz degeneration a,ninaC,pinta, C,retinophilin,Rhodopsi PIP5K59B,rdg n 5,Rhodopsin Biological detection of light B,rdgC,Rh5,R 6,Shaker,transient Over-expressed 48 AEL 1301 process stimulus GO:0009583 4.60E-06 4.42 18 51 5.68 35.3% 1.4% h6,rtp,Sh,trpl receptor potential-like

Autophagy-related 1,Autophagy-related Atg1,Atg13,At 13,Autophagy-related Biological intestinal epithelial g17,Atg9,upd 17,Autophagy-related Over-expressed 48 AEL 1301 process structure maintenance GO:0060729 1.20E-05 48.16 6 7 0.78 85.7% 0.5% 2,upd3 9,unpaired 2,unpaired 3 Adenylyl cyclase 78C,Arrestin 1,Arrestin 2,cacophony,Ceramide kinase,Chemosensory protein B 42c,dally- like,G protein beta- subunit 76C,GNBP-like 3,inactivation no afterpotential C,Ionotropic receptor 21a,Ionotropic receptor 25a,Ionotropic receptor 62a,Ionotropic receptor 76b,lazaro,neither Ac78C,Arr1,Ar inactivation nor r2,cac,Cerk,Ch afterpotential eB42c,dlp,Gb C,Odorant receptor eta76C,GNBP- 82a,Phosphatidylinosito like3,inaC,Ir21 l 4-phosphate 5-kinase a,Ir25a,Ir62a,I at r76b,laza,nina 59B,primacord,prolong C,Or82a,pinta ed depolarization ,PIP5K59B,pri afterpotential (PDA) is m,rdgB,rdgC, not apparent,retinal Biological Rh5,Rh6,rtp,S degeneration B,retinal Over-expressed 48 AEL 1301 process detection of stimulus GO:0051606 3.20E-05 4.08 16 48 5.3 33.3% 1.2% h,stj,trpl degeneration

Attacin-A,Attacin- B,Attacin-C,Attacin- D,Cecropin A1,Cecropin A2,Diptericin B,Drosocin,elevated during infection,listericin,Metc hnikowin,modular AttA,AttB,Att serine C,AttD,CecA1, protease,Peptidoglycan CecA2,DptB,D recognition protein ro,edin,Listeri LF,Peptidoglycan cin,modSP,Mt recognition protein k,PGRP- SB1,Peptidoglycan LF,PGRP- recognition protein defense response to SB1,PGRP- SC1a,Peptidoglycan Biological Gram-positive SC1a,PGRP- recognition protein Over-expressed 48 AEL 1301 process bacterium GO:0050830 3.50E-05 4.04 16 48 5.35 33.3% 1.2% SC1b SC1b 5-hydroxytryptamine (serotonin) receptor 1A,amnesiac,cacophon y,datilografo,Epidermal stripes and patches,ether a gogo,Forkhead box P,Gustatory receptor 33a,Gustatory receptor 39a,Gustatory receptor 94a,Insulin-like peptide 3,Insulin-like receptor,lectin- 5- 46Ca,lectin- HT1A,amn,ca 46Cb,Lnk,metabotropic c,CG10433,da Glutamate ti,eag,Esp,Fox Receptor,Neuroligin P,Gr33a,Gr39 2,Octopamine receptor a,Gr94a,Ilp3,I in mushroom nR,lectin- bodies,Odorant-binding 46Ca,lectin- protein 46Cb,Lnk,mGl 56h,paralytic,Phosphodi uR,Nlg2,Oam esterase b,Obp56h,par 1c,Shaker,SIFamide Biological a,Pde1c,Sh,SI receptor,spineless,take Over-expressed 48 AEL 1301 process mating behavior GO:0007617 6.10E-05 2.67 26 105 11.7 24.8% 2.0% FaR,ss,to out,uncharacterized Autophagy-related 1,Autophagy-related 17,Autophagy-related 18a,Autophagy-related 6,Autophagy-related 8a,Autophagy-related 9,BIR repeat containing ubiquitin-conjugating Atg1,Atg17,At enzyme,chico,CREB- g18a,Atg6,At regulated transcription g8a,Atg9,Bruc coactivator,Dopamine 1- e,CG10924,ch like receptor ico,Crtc,Dop1 1,Ecdysone-inducible R1,Ets96B,fox gene o,Gnmt,Iml1,I L2,Ets96B,forkhead mpL2,InR,Lst, box, sub-group mio,mthl8,My O,Glycine N- c,Oamb,p53,P methyltransferase,Incr epck,Pi3K59F, eased Rel,REPTOR,R minichromosome loss EPTOR- 1,Insulin-like BP,Rheb,Ric,r receptor,Limostatin,me udhira,Slob,S thuselah-like 8,missing NF4Agamma, oocyte,Myc,Octopamin Biological Syx17,Thor,to, e receptor in Over-expressed 48 AEL 1301 process response to starvation GO:0042594 8.60E-05 3.48 17 57 6.27 29.8% 1.3% Wdr59 mushroom chico,Ecdysone- inducible gene L2,forkhead box, sub- group O,Insulin-like Biological entry into reproductive chico,foxo,Ilp peptide 3,Insulin-like Over-expressed 48 AEL 1301 process diapause GO:0055116 9.30E-05 40.09 5 6 0.67 83.3% 0.4% 3,ImpL2,InR receptor Arrestin 1,Arrestin 2,Autophagy-related 1,Autophagy-related 13,Autophagy-related 17,Autophagy-related 9,C-terminal Src kinase,cacophony,Calbi ndin 53E,caravaggio,chico,DJ- 1alpha,Dopamine 1-like receptor Arr1,Arr2,Atg 1,dyschronic,Insulin-like 1,Atg13,Atg1 receptor,Inverted 7,Atg9,cac,ca repeat-binding v,Cbp53E,chic protein,meiotic o,Csk,DJ- recombination 1alpha,Dop1R 11,Mitogen-activated 1,dysc,InR,Irb protein kinase p,Mkp3,mre1 phosphatase 3,neither 1,nAChRalpha inactivation nor 6,Nap1,ninaC, afterpotential p53,Pi3K59F,r C,nicotinic ad50,RanBPM Acetylcholine Receptor ,Smg5,Smg6, alpha6,Nucleosome Biological anatomical structure sqa,srp,Syx17, assembly protein Over-expressed 48 AEL 1301 process homeostasis GO:0060249 0.00013 2.24 33 153 17.04 21.6% 2.5% upd2,upd3,ver 1,p53,Phosphotidylinosi Autophagy-related 1,Autophagy-related 17,Autophagy-related 18a,Autophagy-related 6,Autophagy-related 8a,Autophagy-related Atg1,Atg17,At 9,BIR repeat containing g18a,Atg6,At ubiquitin-conjugating g8a,Atg9,Bruc enzyme,chico,CREB- e,CG10924,C regulated transcription G32206,CG34 coactivator,Dopamine 1- 402,chico,Crtc like receptor ,Dop1R1,Ets9 1,Ecdysone-inducible 6B,foxo,Gnmt gene ,Iml1,ImpL2,I L2,Ets96B,forkhead nR,Lst,mio,mt box, sub-group hl8,Myc,Oam O,Glycine N- b,p53,Pepck,P methyltransferase,Incr i3K59F,Rel,RE eased PTOR,REPTO minichromosome loss R- 1,Insulin-like BP,Rheb,Ric,r receptor,Limostatin,me udhira,Sh,Slo thuselah-like 8,missing b,SNF4Agam oocyte,Myc,Octopamin Biological response to ma,Syx17,Tho e receptor in Over-expressed 48 AEL 1301 process extracellular stimulus GO:0009991 0.00017 3 19 71 7.81 26.8% 1.5% r,to,Wdr59 mushroom

Autophagy-related 1,Autophagy-related 17,Autophagy-related 18a,Autophagy-related 6,Autophagy-related 8a,Autophagy-related 9,BIR repeat containing ubiquitin-conjugating enzyme,chico,forkhead box, sub-group O,Glycine N- methyltransferase,Incr eased minichromosome loss Atg1,Atg17,At 1,Insulin-like g18a,Atg6,At receptor,Limostatin,mi g8a,Atg9,Bruc ssing e,chico,foxo,G oocyte,Myc,p53,Phosph nmt,Iml1,InR, otidylinositol 3 kinase Lst,mio,Myc,p 59F,Relish,SNF4/AMP- 53,Pi3K59F,R activated protein el,SNF4Agam kinase gamma Biological cellular response to ma,Syx17,Wd subunit,Syntaxin 17,WD Over-expressed 48 AEL 1301 process extracellular stimulus GO:0031668 0.00022 2.74 21 83 9.25 25.3% 1.6% r59 repeat domain 59 amn,Arr1,Atg amnesiac,Arrestin 18b,Atg8a,bu 1,Autophagy-related n,cac,CCKLR- 18b,Autophagy-related 17D1,CCKLR- 8a,bunched,cacophony, 17D3,CG1036 Cholecystokinin-like 2,CG10702,C receptor at G12896,CG13 17D1,Cholecystokinin- 995,CG1657,C like receptor at G16721,CG32 17D3,Corepressor of 547,CG32683, Pangolin,Cyclic CG34393,CG4 nucleotide-gated ion 2366,CG4245 channel- 0,CG42541,C like,Cyp6g2,Cytochrome G5160,CG593 P450-18a1,Death 7,CG9003,CG resistor Adh domain 9098,CG9272, containing Cngl,Coop,Cyp target,Dopamine 2-like 18a1,Cyp6g2, receptor,earmuff,erect Dop2R,Drat,e wing,ether a go- ag,erm,ewg,F go,Follistatin,germ cell- s,GABA-B- less,Glycoprotein R3,Gadd45,gc hormone beta l,Gpb5,Gyc32 5,Growth arrest and E,hiw,Irbp,lb DNA damage-inducible Biological cellular response to m,Listericin, 45,Guanyl cyclase at Over-expressed 48 AEL 1301 process stimulus GO:0051716 0.00024 1.34 223 1653 181.85 13.5% 17.1% magu,mio,Mn 32E,highwire,Inverted Ca[2+]-channel protein alpha[[1]] subunit T,cacophony,ether a gogo,Eye-enriched kainate receptor,fife,GluClalph a,Glycine receptor,julius seizure,Na channel protein 60E,nicotinic Acetylcholine Receptor alpha2,nicotinic Acetylcholine Receptor Ca- alpha3,nicotinic alpha1T,cac,e Acetylcholine Receptor ag,Ekar,Fife,G alpha5,nicotinic luClalpha,Grd, Acetylcholine Receptor jus,nAChRalp alpha6,nicotinic ha2,nAChRalp Acetylcholine Receptor ha3,nAChRalp alpha7,paralytic,Resist ha5,nAChRalp ant to ha6,nAChRalp dieldrin,Shaker,Shaker ha7,NaCP60E, cognate b,slowpoke para,Rdl,Sh,S 2,Slowpoke binding Biological regulation of hab,SK,SLO2, protein,small Over-expressed 48 AEL 1301 process membrane potential GO:0042391 0.00026 3.24 16 56 6.21 28.6% 1.2% Slob conductance calcium-

CREB-regulated transcription coactivator,ether a gogo,Glycine N- methyltransferase,Hyp erkinetic,Insulin-like receptor,Proliferating cell nuclear antigen 2,Shaker,Shaker CG32206,CG3 cognate b,Shaker 4189,CG3438 cognate w,Transient 4,CG34402,Cr receptor potential tc,eag,Gnmt, cation channel, Hk,InR,PCNA2 subfamily Biological protein complex ,Sh,Shab,Sha M,uncharacterized Over-expressed 48 AEL 1301 process oligomerization GO:0051259 0.00032 3.53 14 46 5.12 30.4% 1.1% w,Trpm protein Autophagy-related 1,Autophagy-related 13,Autophagy-related Atg1,Atg13,At 17,Autophagy-related g17,Atg18a,A 18a,Autophagy-related Biological tg6,Atg9,ref(2 6,Autophagy-related Over-expressed 48 AEL 1301 process selective autophagy GO:0061912 0.00035 8.03 7 14 1.56 50.0% 0.5% )P 9,refractory to sigma P Adenylyl cyclase 78C,amnesiac,cacopho ny,Cyclic nucleotide- gated ion channel- like,Dopamine 1-like receptor 1,Dopamine 2- like receptor,Guanyl cyclase at 32E,Guanylyl cyclase beta-subunit at 100B,inactivation no afterpotential C,Leucine-rich repeat- containing G protein- coupled receptor Ac78C,amn,ca 3,Limostatin,NADPH c,CG16721,CG oxidase,Nitric oxide 42260,CG433 synthase,Octopamine 73,CG7497,Cn beta1 gl,Dop1R1,Do receptor,Octopamine p2R,Gyc32E,G beta3 receptor,retinal ycbeta100B,in degeneration aC,Lgr3,Lst,N C,transient receptor os,Nox,Octbet potential-like,Troponin a1R,Octbeta3 C at Biological second-messenger- R,rdgC,TpnC4 41C,uncharacterized Over-expressed 48 AEL 1301 process mediated signaling GO:0019932 0.00044 2.51 22 93 10.36 23.7% 1.7% 1C,trpl protein

cacophony,dally- like,dyschronic,inactivat ion no afterpotential C,Rhodopsin 5,Rhodopsin 6,transient cac,CG4025,dl receptor potential- Biological sensory perception of p,dysc,inaC,R like,uncharacterized Over-expressed 48 AEL 1301 process light stimulus GO:0050953 0.00056 5.84 8 19 2.12 42.1% 0.6% h5,Rh6,trpl protein

borderless,Down syndrome cell adhesion molecule 2,Down syndrome cell adhesion molecule 3,Down syndrome cell adhesion bdl,CG44153, molecule 4,Ecdysone- Dscam2,Dsca inducible gene m3,Dscam4,fr L2,furry,Semaphorin Biological dendrite self- y,ImpL2,Sema 2b,uncharacterized Over-expressed 48 AEL 1301 process avoidance GO:0070593 0.00056 5.84 8 19 2.12 42.1% 0.6% 2b protein

Adenylyl cyclase 78C,cacophony,dally- like,inactivation no afterpotential C,Ionotropic receptor 21a,Ionotropic receptor 25a,Ionotropic receptor 76b,Odorant receptor Ac78C,cac,dlp 82a,primacord,retinal ,inaC,Ir21a,Ir2 degeneration detection of stimulus 5a,Ir76b,Or82 C,straightjacket,transie Biological involved in sensory a,prim,rdgC,st nt receptor potential- Over-expressed 48 AEL 1301 process perception GO:0050906 0.00059 3.72 12 38 4.23 31.6% 0.9% j,trpl like

Autophagy-related 1,Autophagy-related 101,Autophagy-related 13,Autophagy-related 17,Autophagy-related Atg1,Atg101, 18a,Autophagy-related Atg13,Atg17, 18b,Autophagy-related Atg18a,Atg18 6,Autophagy-related b,Atg6,Atg8a, 8a,Autophagy-related Biological autophagosome Atg9,mv,Pi3K 9,mauve,Phosphotidylin Over-expressed 48 AEL 1301 process organization GO:1905037 0.00059 4.02 11 33 3.68 33.3% 0.8% 59F ositol 3 kinase 59F Augmenter of liver regeneration,bunched,I maginal disc growth factor 1,p53,Serpin Alr,bun,Idgf1, 88Eb,Sex Biological p53,Spn88Eb, lethal,Topoisomerase Over-expressed 48 AEL 1301 process tissue regeneration GO:0042246 6.00E-04 7.02 7 15 1.67 46.7% 0.5% Sxl,Top3alpha 3alpha Arrestin 1,Arrestin 2,inactivation no afterpotential C,neither Biological adaptation of Arr1,Arr2,inaC inactivation nor Over-expressed 48 AEL 1301 process signaling pathway GO:0023058 7.00E-04 32.04 4 5 0.56 80.0% 0.3% ,ninaC afterpotential C ade5,adenosine 2,Adenylosuccinate Biological ade2,ade5,Ad Synthetase,AMP Over-expressed 48 AEL 1301 process IMP metabolic process GO:0046040 7.00E-04 32.04 4 5 0.56 80.0% 0.3% SS,AMPdeam deaminase

Arrestin 1,Arrestin 2,G protein beta-subunit 76C,inactivation no afterpotential C,neither inactivation nor afterpotential C,Phosphatidylinositol 4- phosphate 5-kinase at Arr1,Arr2,Gbe 59B,retinal ta76C,inaC,ni degeneration B,retinal naC,PIP5K59B degeneration Biological phototransduction, ,rdgB,rdgC,trp C,transient receptor Over-expressed 48 AEL 1301 process visible light GO:0007603 7.00E-04 4.82 9 24 2.67 37.5% 0.7% l potential-like

Autophagy-related 1,Autophagy-related 13,Autophagy-related 17,Autophagy-related 9,C-terminal Src kinase,Mitogen- activated protein Atg1,Atg13,At kinase phosphatase g17,Atg9,Csk, 3,Phosphotidylinositol 3 Biological epithelial structure Mkp3,Pi3K59F kinase 59F,unpaired Over-expressed 48 AEL 1301 process maintenance GO:0010669 7.00E-04 4.82 9 24 2.67 37.5% 0.7% ,upd2,upd3 2,unpaired 3 Ca[2+]-channel protein alpha[[1]] subunit Ca- T,Glycine receptor,Na alpha1T,Grd, channel protein Biological NaCP60E,Sh,S 60E,Shaker,Shaker Over-expressed 48 AEL 1301 process action potential GO:0001508 0.00071 13.36 5 8 0.89 62.5% 0.4% hab cognate b Arrestin 2,Eye-enriched kainate receptor,inactivation no afterpotential C,lazaro,neither Biological response to light Arr2,Ekar,inaC inactivation nor Over-expressed 48 AEL 1301 process intensity GO:0009642 0.00071 13.36 5 8 0.89 62.5% 0.4% ,laza,ninaC afterpotential C chico,Ecdysone- inducible gene L2,forkhead box, sub- group O,Insulin-like Biological chico,foxo,Ilp peptide 3,Insulin-like Over-expressed 48 AEL 1301 process dormancy process GO:0022611 0.00071 13.36 5 8 0.89 62.5% 0.4% 3,ImpL2,InR receptor

Arrestin 1,Arrestin 2,Eye-enriched kainate receptor,G protein beta- subunit 76C,inactivation no afterpotential C,neither inactivation nor afterpotential C,Phosphatidylinositol 4- phosphate 5-kinase at Arr1,Arr2,Ekar 59B,retinal ,Gbeta76C,ina degeneration B,retinal C,ninaC,PIP5K degeneration Biological cellular response to 59B,rdgB,rdg C,Rhodopsin Over-expressed 48 AEL 1301 process light stimulus GO:0071482 0.00079 3.85 11 34 3.79 32.4% 0.8% C,Rh5,Rh6 5,Rhodopsin 6 amnesiac,Anaplastic lymphoma kinase,chico,derailed,D opamine 1-like receptor 1,futsch,Gustatory receptor 33a,Gustatory receptor 39a,Gustatory receptor 94a,Na channel protein 60E,Neuropeptide F Alk,amn,CG13 receptor,Octopamine 377,chico,Dop receptor in mushroom 1R1,drl,futsch bodies,Odorant-binding ,Gr33a,Gr39a, protein 56d,Odorant- Gr94a,NaCP6 binding protein 0E,NPFR,Oam 56h,Pinocchio,radish,Re b,Obp56d,Ob sistant to Biological chemosensory p56h,Pino,rad dieldrin,Shaker,unchara Over-expressed 48 AEL 1301 process behavior GO:0007635 0.00085 2.56 19 79 8.8 24.1% 1.5% ,Rdl,Sh cterized protein

Arrestin 1,Arrestin 2,G protein beta-subunit 76C,inactivation no afterpotential C,neither inactivation nor deactivation of Arr1,Arr2,Gbe afterpotential C,retinal Biological rhodopsin mediated ta76C,inaC,ni degeneration B,retinal Over-expressed 48 AEL 1301 process signaling GO:0016059 0.00096 6.24 7 16 1.78 43.8% 0.5% naC,rdgB,rdgC degeneration C

Arrestin 1,Arrestin 2,Ets96B,forkhead box, sub-group O,G protein beta-subunit 76C,inactivation no afterpotential C,neither regulation of G Arr1,Arr2,Ets9 inactivation nor protein-coupled 6B,foxo,Gbet afterpotential C,retinal Biological receptor signaling a76C,inaC,nin degeneration B,retinal Over-expressed 48 AEL 1301 process pathway GO:0008277 0.00099 4.52 9 25 2.78 36.0% 0.7% aC,rdgB,rdgC degeneration C Autophagy-related 1,Autophagy-related 101,Autophagy-related 13,Autophagy-related 17,Autophagy-related Atg1,Atg101, 18a,Autophagy-related Atg13,Atg17, 6,Autophagy-related larval midgut cell Atg18a,Atg6, 8a,Autophagy-related Biological programmed cell Atg8a,Atg9,Pi 9,Phosphotidylinositol 3 Over-expressed 48 AEL 1301 process death GO:0035096 0.00099 4.52 9 25 2.78 36.0% 0.7% 3K59F kinase 59F 5-HT1A,5- 5-hydroxytryptamine HT2B,Alk,CCK (serotonin) receptor LR- 1A,5- 17D1,CCKLR- hydroxytryptamine 17D3,CG1070 (serotonin) receptor 2,CG13579,C 2B,Anaplastic G13995,CG31 lymphoma 760,CG32206, kinase,Cholecystokinin- CG32547,CG3 like receptor at 4402,CG4379 17D1,Cholecystokinin- 5,CG44153,C like receptor at G7497,CNMa 17D3,CNMamide R,Dh44- Receptor,derailed,Derai R1,Dop1R1,D led 2,Diuretic hormone op2R,drl,Drl- 44 receptor 2,Ekar,ftz- 1,Dopamine 1-like f1,GABA-B- receptor 1,Dopamine 2- R3,GluClalpha like receptor,Eye- ,GluRIA,GNBP enriched kainate 2,Gr33a,Gr39 receptor,ftz a,Gr94a,Grd, transcription factor Gyc32E,InR,Ir 1,GluClalpha,Glutamat 21a,Ir25a,Ir76 e receptor IA,Glycine b,kek6,Lgr3,M receptor,Gram- Molecular molecular transducer et,mGluR,Ms negative bacteria Over-expressed 48 AEL 1301 function activity GO:0060089 3.20E-11 2.75 71 291 31.96 24.4% 5.5% R1,mthl8,nAC binding protein 5-hydroxytryptamine (serotonin) receptor 1A,5- hydroxytryptamine 5-HT1A,5- (serotonin) receptor HT2B,CCKLR- 2B,Cholecystokinin-like 17D1,CCKLR- receptor at 17D3,CG1357 17D1,Cholecystokinin- 9,CG13995,C like receptor at G31760,CG32 17D3,CNMamide 547,CG43795, Receptor,Diuretic CG44153,CG7 hormone 44 receptor 497,CNMaR,D 1,Dopamine 1-like h44- receptor 1,Dopamine 2- R1,Dop1R1,D like receptor,Leucine- op2R,GABA-B- rich repeat-containing R3,Lgr3,mGlu G protein-coupled R,MsR1,mthl receptor 8,NPFR,Oamb 3,metabotropic GABA- ,Octbeta1R,O B receptor subtype ctbeta3R,PK1- 3,metabotropic R,PK2- Glutamate R2,Rh5,Rh6,R Receptor,methuselah- Ya- like 8,Myosuppressin Molecular G protein-coupled R,SIFaR,smog receptor Over-expressed 48 AEL 1301 function receptor activity GO:0004930 1.10E-08 3.92 32 100 10.98 32.0% 2.5% ,TkR86C 1,Neuropeptide F Ca[2+]-channel protein alpha[[1]] subunit T,cacophony,Cyclic nucleotide-gated ion channel-like,ether a gogo,Eye-enriched kainate receptor,GluClalpha,Gl Ca- utamate receptor alpha1T,cac,C IA,Glycine G15270,CG42 receptor,Hyperkinetic,Io 260,CG4587,C notropic receptor ngl,eag,Ekar, 21a,Ionotropic receptor GluClalpha,Gl 25a,Ionotropic receptor uRIA,Grd,Hk,Ir 62a,Ionotropic receptor 21a,Ir25a,Ir62 76b,Na channel protein a,Ir76b,nAChR 60E,nicotinic alpha2,nAChR Acetylcholine Receptor alpha3,nAChR alpha2,nicotinic alpha5,nAChR Acetylcholine Receptor alpha6,nAChR alpha3,nicotinic alpha7,NaCP6 Acetylcholine Receptor 0E,Nmdar2,R alpha5,nicotinic dl,Sh,Shab,Sh Acetylcholine Receptor Molecular ion gated channel aw,SK,SLO2,s alpha6,nicotinic Over-expressed 48 AEL 1301 function activity GO:0022839 1.90E-08 3.91 31 97 10.65 32.0% 2.4% tj,Trpm Acetylcholine Receptor 5-hydroxytryptamine (serotonin) receptor 1A,5- hydroxytryptamine (serotonin) receptor 2B,Dopamine 1-like receptor 1,Dopamine 2- like receptor,Eye- enriched kainate receptor,Glutamate 5-HT1A,5- receptor IA,Glycine HT2B,CG4379 receptor,Ionotropic 5,Dop1R1,Dop receptor 21a,Ionotropic 2R,Ekar,GABA- receptor 25a,Ionotropic B- receptor R3,GluRIA,Gr 76b,metabotropic d,Ir21a,Ir25a,I GABA-B receptor r76b,nAChRal subtype 3,nicotinic pha2,nAChRal Acetylcholine Receptor pha3,nAChRal alpha2,nicotinic pha5,nAChRal Acetylcholine Receptor pha6,nAChRal alpha3,nicotinic pha7,Nmdar2 Acetylcholine Receptor ,Oamb,Octbet alpha5,nicotinic Molecular neurotransmitter a1R,Octbeta3 Acetylcholine Receptor Over-expressed 48 AEL 1301 function receptor activity GO:0030594 2.30E-08 5.51 22 55 6.04 40.0% 1.7% R,Rdl alpha6,nicotinic Ca[2+]-channel protein alpha[[1]] subunit T,cacophony,Cyclic nucleotide-gated ion channel-like,ether a go- Ca- go,Eye-enriched alpha1T,cac,C kainate G15270,CG16 receptor,GluClalpha,Gl 88,CG42260,C utamate receptor G4587,Cngl,e IA,Glycine ag,Ekar,GluCl receptor,Hyperkinetic,in alpha,GluRIA, active,Ionotropic Grd,Hk,iav,Ir2 receptor 21a,Ionotropic 1a,Ir25a,Ir62a receptor 25a,Ionotropic ,Ir76b,nAChRa receptor 62a,Ionotropic lpha2,nAChRa receptor 76b,Na lpha3,nAChRa channel protein lpha5,nAChRa 60E,nicotinic lpha6,nAChRa Acetylcholine Receptor lpha7,NaCP60 alpha2,nicotinic E,Nmdar2,par Acetylcholine Receptor a,Rdl,Sh,Shab alpha3,nicotinic ,Shaw,SK,SLO Acetylcholine Receptor 2,stj,Task6,trp alpha5,nicotinic Molecular l,Trpm,unc80, Acetylcholine Receptor Over-expressed 48 AEL 1301 function ion channel activity GO:0005216 7.10E-08 3.11 38 140 15.38 27.1% 2.9% wtrw alpha6,nicotinic Ca[2+]-channel protein alpha[[1]] subunit T,cacophony,Cyclic nucleotide-gated ion channel-like,ether a go- Ca- go,Eye-enriched alpha1T,cac,C kainate G15270,CG16 receptor,GluClalpha,Gl 88,CG42260,C utamate receptor G4587,Cngl,e IA,Glycine ag,Ekar,GluCl receptor,Hyperkinetic,in alpha,GluRIA, active,Ionotropic Grd,Hk,iav,Ir2 receptor 21a,Ionotropic 1a,Ir25a,Ir62a receptor 25a,Ionotropic ,Ir76b,nAChRa receptor 62a,Ionotropic lpha2,nAChRa receptor 76b,Na lpha3,nAChRa channel protein lpha5,nAChRa 60E,nicotinic lpha6,nAChRa Acetylcholine Receptor lpha7,NaCP60 alpha2,nicotinic E,Nmdar2,par Acetylcholine Receptor a,Rdl,Sh,Shab alpha3,nicotinic ,Shaw,SK,SLO Acetylcholine Receptor 2,stj,Task6,trp alpha5,nicotinic Molecular l,Trpm,unc80, Acetylcholine Receptor Over-expressed 48 AEL 1301 function channel activity GO:0015267 5.90E-07 2.8 38 151 16.59 25.2% 2.9% wtrw alpha6,nicotinic

Eye-enriched kainate receptor,Glutamate receptor IA,Glycine receptor,Ionotropic receptor 21a,Ionotropic receptor 25a,Ionotropic receptor 76b,nicotinic Acetylcholine Receptor alpha2,nicotinic Ekar,GluRIA,G Acetylcholine Receptor rd,Ir21a,Ir25a, alpha3,nicotinic Ir76b,nAChRal Acetylcholine Receptor pha2,nAChRal alpha5,nicotinic pha3,nAChRal Acetylcholine Receptor pha5,nAChRal alpha6,nicotinic pha6,nAChRal Acetylcholine Receptor Molecular transmitter-gated ion pha7,Nmdar2 alpha7,NMDA receptor Over-expressed 48 AEL 1301 function channel activity GO:0022824 1.50E-05 5.61 13 32 3.51 40.6% 1.0% ,Rdl 2,Resistant to dieldrin Cyclic nucleotide-gated ion channel-like,Eye- enriched kainate receptor,GluClalpha,Gl utamate receptor IA,Glycine receptor,Ionotropic receptor 21a,Ionotropic receptor 25a,Ionotropic receptor 62a,Ionotropic receptor 76b,nicotinic Acetylcholine Receptor alpha2,nicotinic Acetylcholine Receptor CG42260,Cngl alpha3,nicotinic ,Ekar,GluClalp Acetylcholine Receptor ha,GluRIA,Gr alpha5,nicotinic d,Ir21a,Ir25a,I Acetylcholine Receptor r62a,Ir76b,nA alpha6,nicotinic ChRalpha2,nA Acetylcholine Receptor ChRalpha3,nA alpha7,NMDA receptor ChRalpha5,nA 2,Resistant to ChRalpha6,nA dieldrin,Transient ChRalpha7,N receptor potential Molecular ligand-gated channel mdar2,Rdl,Tr cation channel, Over-expressed 48 AEL 1301 function activity GO:0022834 1.70E-05 3.9 18 56 6.15 32.1% 1.4% pm subfamily Ca- Ca[2+]-channel protein alpha1T,cac,C alpha[[1]] subunit G10804,CG14 T,cacophony,Cyclic 606,CG15270, nucleotide-gated ion CG1628,CG16 channel-like,ether a go- 88,CG3285,C go,Excitatory amino G33282,CG33 acid transporter 2,Eye- 310,CG42260, enriched kainate CG43066,CG4 receptor,Glutamate 476,CG4587,C receptor IA,Glycine G5646,Cngl,E receptor,Hyperkinetic,in aat2,eag,Ekar active,Ionotropic ,GluRIA,Grd,H receptor 25a,Ionotropic k,iav,Ir25a,Ir7 receptor 76b,Lithium- 6b,List,MME1 inducible SLC6 ,nAChRalpha2 transporter,Mitochondr ,nAChRalpha3 ial Magnesium ,nAChRalpha5 Exporter 1,Na channel ,nAChRalpha6 protein 60E,Na[+]/H[+] ,nAChRalpha7 hydrogen exchanger ,NaCP60E,Nh 3,nicotinic e3,NKCC,Nmd Acetylcholine Receptor ar2,para,rdgB alpha2,nicotinic cation ,Sh,Shab,Sha Acetylcholine Receptor Molecular transmembrane w,SK,SLO2,stj alpha3,nicotinic Over-expressed 48 AEL 1301 function transporter activity GO:0008324 2.30E-05 2.02 52 267 29.33 19.5% 4.0% ,Task6,Tret1- Acetylcholine Receptor

Ca[2+]-channel protein alpha[[1]] subunit T,cacophony,ether a gogo,Hyperkinetic,Na Ca- channel protein alpha1T,cac,C 60E,NMDA receptor G4587,eag,Hk 2,Shaker,Shaker ,NaCP60E,Nm cognate b,Shaker dar2,Sh,Shab, cognate w,slowpoke Molecular voltage-gated cation Shaw,SLO2,st 2,straightjacket,unchar Over-expressed 48 AEL 1301 function channel activity GO:0022843 2.50E-05 5.78 12 29 3.19 41.4% 0.9% j acterized protein Ca[2+]-channel protein alpha[[1]] subunit T,cacophony,ether a gogo,Excitatory amino acid transporter 2,Eye- enriched kainate receptor,Glutamate receptor IA,Hyperkinetic,inactive Ca- ,Ionotropic receptor alpha1T,cac,C 76b,Lithium-inducible G10804,CG16 SLC6 88,CG33310,C transporter,Mitochondr G43066,CG44 ial Magnesium 76,CG4587,Ea Exporter 1,Na channel at2,eag,Ekar, protein 60E,Na[+]/H[+] GluRIA,Hk,iav, hydrogen exchanger Ir76b,List,MM 3,paralytic,retinal E1,NaCP60E, degeneration Nhe3,NKCC,p B,Shaker,Shaker ara,rdgB,Sh,S cognate b,Shaker hab,Shaw,SK, cognate w,slowpoke SLO2,stj,Task 2,small conductance metal ion 6,trpl,Trpm,w calcium-activated Molecular transmembrane trw,Zip99C,Zn potassium Over-expressed 48 AEL 1301 function transporter activity GO:0046873 8.00E-05 2.27 34 158 17.35 21.5% 2.6% T35C channel,sodium

GluClalpha,Glycine receptor,nicotinic Acetylcholine Receptor alpha2,nicotinic Acetylcholine Receptor GluClalpha,Gr alpha3,nicotinic d,nAChRalpha Acetylcholine Receptor 2,nAChRalpha alpha5,nicotinic excitatory 3,nAChRalpha Acetylcholine Receptor extracellular ligand- 5,nAChRalpha alpha6,nicotinic Molecular gated ion channel 6,nAChRalpha Acetylcholine Receptor Over-expressed 48 AEL 1301 function activity GO:0005231 9.10E-05 11.43 7 12 1.32 58.3% 0.5% 7 alpha7

Cyclic nucleotide-gated ion channel-like,Eye- enriched kainate receptor,Glutamate receptor IA,Ionotropic receptor 25a,Ionotropic receptor 76b,nicotinic Acetylcholine Receptor alpha2,nicotinic Acetylcholine Receptor alpha3,nicotinic Acetylcholine Receptor alpha5,nicotinic CG42260,Cngl Acetylcholine Receptor ,Ekar,GluRIA,I alpha6,nicotinic r25a,Ir76b,nA Acetylcholine Receptor ChRalpha2,nA alpha7,NMDA receptor ChRalpha3,nA 2,Transient receptor ChRalpha5,nA potential cation ChRalpha6,nA channel, subfamily Molecular ligand-gated cation ChRalpha7,N M,uncharacterized Over-expressed 48 AEL 1301 function channel activity GO:0099094 0.00022 3.94 13 40 4.39 32.5% 1.0% mdar2,Trpm protein 5-HT1A,5- 5-hydroxytryptamine HT2B,Alk,CCK (serotonin) receptor LR- 1A,5- 17D1,CCKLR- hydroxytryptamine 17D3,CG1070 (serotonin) receptor 2,CG13579,C 2B,Anaplastic G13995,CG31 lymphoma 760,CG32547, kinase,Cholecystokinin- CG43795,CG4 like receptor at 4153,CG7497, 17D1,Cholecystokinin- CNMaR,Dh44- like receptor at R1,Dop1R1,D 17D3,CNMamide op2R,drl,Drl- Receptor,derailed,Derai 2,Ekar,GABA- led 2,Diuretic hormone B- 44 receptor R3,GluClalpha 1,Dopamine 1-like ,GluRIA,Gr33 receptor 1,Dopamine 2- a,Gr39a,Gr94 like receptor,Eye- a,Grd,InR,Ir21 enriched kainate a,Ir25a,Ir76b, receptor,GluClalpha,Gl Lgr3,mGluR, utamate receptor MsR1,mthl8,n IA,Glycine AChRalpha2,n receptor,Gustatory transmembrane AChRalpha3,n receptor 33a,Gustatory Molecular signaling receptor AChRalpha5,n receptor 39a,Gustatory Over-expressed 48 AEL 1301 function activity GO:0004888 0.00024 2.51 24 105 11.26 22.9% 1.8% AChRalpha6,n receptor 94a,Insulin-

borderless,Down syndrome cell adhesion molecule 2,Down syndrome cell adhesion molecule 3,Down syndrome cell adhesion bdl,CG44153, molecule 4,Ecdysone- Dscam2,Dsca inducible gene Molecular cell-cell adhesion m3,Dscam4,I L2,uncharacterized Over-expressed 48 AEL 1301 function mediator activity GO:0098632 0.00025 12.23 6 10 1.1 60.0% 0.5% mpL2 protein

Dynein heavy chain at 62B,Dynein heavy chain at 89D,Dynein heavy ATP-dependent CG3339,CG94 chain at 93AB,Kinesin microtubule motor 92,Dhc62B,Dh family member Molecular activity, minus-end- c93AB,Dhc98 3C,uncharacterized Over-expressed 48 AEL 1301 function directed GO:0008569 0.00049 9.78 6 11 1.21 54.5% 0.5% D,Kif3C protein

Cholecystokinin-like receptor at 17D1,Cholecystokinin- like receptor at 17D3,CNMamide Receptor,Diuretic hormone 44 receptor 1,Leucine-rich repeat- containing G protein- coupled receptor 3,Myosuppressin CCKLR- receptor 17D1,CCKLR- 1,Neuropeptide F 17D3,CG1399 receptor,Pyrokinin 1 5,CG32547,C receptor,Pyrokinin 2 NMaR,Dh44- receptor 2,RYamide R1,Lgr3,MsR1 receptor,SIFamide ,NPFR,PK1- receptor,Tachykinin-like R,PK2-R2,RYa- receptor at Molecular peptide receptor R,SIFaR,TkR8 86C,uncharacterized Over-expressed 48 AEL 1301 function activity GO:0001653 0.00071 3.19 14 50 5.49 28.0% 1.1% 6C protein caravaggio,Inverted cav,Irbp,rad50 repeat-binding Molecular ,Smg5,Smg6, protein,rad50,Smg5,Sm Over-expressed 48 AEL 1301 function telomeric DNA binding GO:0042162 0.00089 8.15 6 12 1.32 50.0% 0.5% ver g6,verrocchio 5- 5-hydroxytryptamine HT1A,Alk,ana (serotonin) receptor 1,Arr1,Arr2,At 1A,Anaplastic g8a,BBS4,bdl, lymphoma Burs,Cbp53E, kinase,anastral spindle Cc2d2a,CCKLR-1,Arrestin 1,Arrestin 17D1,Cep135, 2,Autophagy-related cep290,CG10 8a,Bardet-Biedl 702,CG1126,C syndrome G15666,CG15 4,borderless,Bursicon,C 923,CG16719, albindin CG17387,CG3 53E,Centrosomal 2206,CG3339, protein CG34402,CG4 135kDa,cep290,Cholecy 2366,CG4415 stokinin-like receptor at 3,CG5142,CG 17D1,Choline 9492,ChAT,CLI acetyltransferase,Coile P- d-coil and C2 domain 190,cmpy,Dab containing ,Dhc62B,Dhc9 2A,crimpy,Cytoplasmic 3AB,Dhc98D,d linker protein ia,Dop1R1,dpr 190,defective proboscis 11,dpr12,dpr1 extension response 8,dpr2,dpr20, 11,defective proboscis Cellular dpr4,dpr5,dpr extension response Over-expressed 48 AEL 1301 component cell projection GO:0042995 1.70E-15 2.82 100 423 44.87 23.6% 7.7% 6,drl,Dscam2, 12,defective proboscis 5- 5-hydroxytryptamine HT1A,Ac78C,A (serotonin) receptor lk,Atet,bdl,be 1A,ABC transporter at-Ic,Ca- expressed in alpha1T,CadN trachea,Adenylyl 2,CCKLR- cyclase 78C,Anaplastic 17D1,CG1070 lymphoma 2,CG11425,C kinase,beaten path G13404,CG14 Ic,borderless,Ca[2+]- 606,CG1688,C channel protein G31814,CG32 alpha[[1]] subunit 206,CG3285,C T,Cadherin- G33282,CG33 N2,Cholecystokinin-like 310,CG34402, receptor at CG43373,CG4 17D1,defective 4325,Dh44- proboscis extension R1,DIP- response 11,defective beta,DIP- proboscis extension delta,DIP- response 18,defective eta,Dop1R1,D proboscis extension op2R,dpr11,d response 2,defective pr18,dpr2,dpr proboscis extension 20,dpr5,drl,Dr response 20,defective l- proboscis extension Cellular integral component of 2,Dscam2,Dsc response Over-expressed 48 AEL 1301 component plasma membrane GO:0005887 2.80E-15 2.86 96 401 42.53 23.9% 7.4% am3,Dscam4, 5,derailed,Derailed 5- 5-hydroxytryptamine HT1A,Ac78C,A (serotonin) receptor tet,bdl,beat- 1A,ABC transporter Ic,Ca- expressed in alpha1T,cac,C trachea,Adenylyl adN2,CCKLR- cyclase 78C,beaten 17D1,CG1070 path 2,CG11425,C Ic,borderless,Ca[2+]- G13404,CG14 channel protein 606,CG1688,C alpha[[1]] subunit G31814,CG32 T,cacophony,Cadherin- 206,CG3285,C N2,Cholecystokinin-like G33282,CG33 receptor at 17D1,dally- 310,CG34402, like,defective proboscis CG43373,CG4 extension response 4325,CG4587, 11,defective proboscis Dh44- extension response R1,dia,DIP- 18,defective proboscis beta,DIP- extension response eta,dlp,Dop1R 2,defective proboscis 1,Dop2R,dpr1 extension response 1,dpr18,dpr2, 20,defective proboscis dpr20,dpr4,dp extension response r5,Drl- 4,defective proboscis Cellular plasma membrane 2,Dscam2,Dsc extension response Over-expressed 48 AEL 1301 component part GO:0044459 1.60E-10 2.05 123 668 70.86 18.4% 9.5% am4,Dyb,eag, 5,Derailed 5- 5-hydroxytryptamine HT1A,Atet,At (serotonin) receptor g9,bdl,beat- 1A,ABC transporter Ic,bwa,Ca- expressed in alpha1T,cac,C trachea,Autophagy- adN2,CCKLR- related 9,beaten path 17D1,CCKLR- Ic,borderless,brain 17D3,CG1070 washing,Ca[2+]- 2,CG10804,C channel protein G13404,CG13 alpha[[1]] subunit 579,CG13995, T,cacophony,Cadherin- CG14439,CG1 N2,Cholecystokinin-like 5098,CG1572, receptor at CG15760,CG1 17D1,Cholecystokinin- 688,CG18609, like receptor at CG18635,CG2 17D3,Cyclic nucleotide- 975,CG31272, gated ion channel- CG31321,CG3 like,Cytochrome b5- 1760,CG3181 related,defective 4,CG32547,C proboscis extension G3285,CG332 response 18,defective 82,CG33310,C proboscis extension G33474,CG34 response 2,Derailed 120,CG42260, 2,Diuretic hormone 44 Cellular intrinsic component of CG43066,CG4 receptor 1,Dopamine 2- Over-expressed 48 AEL 1301 component membrane GO:0031224 3.80E-10 1.81 175 1071 113.6 16.3% 13.5% 4325,CG4587, like receptor,Down Ca[2+]-channel protein alpha[[1]] subunit T,cacophony,Cyclic nucleotide-gated ion channel-like,ether a gogo,Glutamate receptor IA,Hyperkinetic,inactive ,Ionotropic receptor Ca- 25a,Ionotropic receptor alpha1T,cac,C 76b,Na channel protein G32206,CG33 60E,nicotinic 310,CG34402, Acetylcholine Receptor CG42260,CG4 alpha2,nicotinic 587,Cngl,eag, Acetylcholine Receptor GluRIA,Hk,iav, alpha3,nicotinic Ir25a,Ir76b,nA Acetylcholine Receptor ChRalpha2,nA alpha5,nicotinic ChRalpha3,nA Acetylcholine Receptor ChRalpha5,nA alpha6,nicotinic ChRalpha6,nA Acetylcholine Receptor ChRalpha7,Na alpha7,NMDA receptor CP60E,Nmdar 2,paralytic,Shaker,Shak 2,para,Sh,Sha er cognate b,Shaker b,Shaw,trpl,Tr cognate w,Transient Cellular transmembrane pm,unc80,wtr receptor potential Over-expressed 48 AEL 1301 component transporter complex GO:1902495 3.40E-09 4.57 29 84 8.91 34.5% 2.2% w cation channel,

Ca[2+]-channel protein alpha[[1]] subunit T,cacophony,Cyclic nucleotide-gated ion channel-like,ether a gogo,Glutamate receptor IA,Hyperkinetic,inactive ,Ionotropic receptor 25a,Ionotropic receptor 76b,Na channel protein Ca- 60E,paralytic,Shaker,Sh alpha1T,cac,C aker cognate b,Shaker G42260,CG45 cognate w,Transient 87,Cngl,eag,G receptor potential luRIA,Hk,iav,Ir cation channel, 25a,Ir76b,NaC subfamily M,transient P60E,para,Sh, receptor potential- Shab,Shaw,tr like,uncharacterized Cellular cation channel pl,Trpm,unc8 protein,uncoordinated Over-expressed 48 AEL 1301 component complex GO:0034703 1.60E-08 6.37 20 47 4.99 42.6% 1.5% 0,wtrw 80,water witch 5-HT1A,Ance- 5-hydroxytryptamine 4,Atet,bdl,bea (serotonin) receptor t-Ic,Ca- 1A,ABC transporter alpha1T,cac,C expressed in adN2,CCKLR- trachea,Ance-4,beaten 17D1,CG1048 path 3,CG10702,C Ic,borderless,Ca[2+]- G10804,CG13 channel protein 404,CG15270, alpha[[1]] subunit CG1688,CG30 T,cacophony,Cadherin- 78,CG31814,C N2,Cholecystokinin-like G32683,CG32 receptor at 812,CG3285,C 17D1,daughter of G33282,CG33 sevenless,defective 310,CG42541, proboscis extension CG44153,CG4 response 18,defective 4325,CG4587, proboscis extension Dh44- response 2,defective R1,dia,DIP- proboscis extension beta,DIP- response 20,defective eta,Dop2R,do proboscis extension s,dpr18,dpr2, response 4,Derailed dpr20,dpr4,Dr 2,diaphanous,Diuretic l- hormone 44 receptor Cellular 2,drongo,Dsca 1,Dopamine 2-like Over-expressed 48 AEL 1301 component cell periphery GO:0071944 3.90E-07 1.61 172 1148 121.77 15.0% 13.2% m4,Dyb,Eaat2 receptor,Down

defective proboscis extension response 11,defective proboscis extension response 12,defective proboscis extension response 18,defective proboscis extension response 2,defective proboscis extension response 20,defective proboscis extension response 4,defective proboscis extension response 5,defective proboscis CG32206,CG3 extension response 4402,dpr11,d 6,Odorant receptor pr12,dpr18,dp 82a,Resistant to r2,dpr20,dpr4, dieldrin,Shaker cognate Cellular neuron projection dpr5,dpr6,Or8 w,uncharacterized Over-expressed 48 AEL 1301 component membrane GO:0032589 1.00E-05 5.84 13 32 3.39 40.6% 1.0% 2a,Rdl,Shaw protein Dynein heavy chain at 62B,Dynein heavy chain at 89D,Dynein heavy chain at CG17387,CG3 93AB,mulet,Outer 339,CG5142,C segment 2,reduced G9492,Dhc62 mechanoreceptor B,Dhc93AB,D potential Cellular hc98D,mlt,Os A,uncharacterized Over-expressed 48 AEL 1301 component ciliary plasm GO:0097014 1.20E-05 8.52 10 20 2.12 50.0% 0.8% eg2,rempA protein

Glutamate receptor IA,Insulin-like receptor,Integrin alphaPS4 subunit,Ionotropic receptor 25a,Ionotropic receptor 76b,metabotropic GABA-B receptor subtype 3,metabotropic Glutamate Receptor,nicotinic Acetylcholine Receptor CG32206,CG3 alpha2,nicotinic 4402,GABA-B- Acetylcholine Receptor R3,GluRIA,InR alpha3,nicotinic ,Ir25a,Ir76b,It Acetylcholine Receptor gaPS4,mGluR alpha5,nicotinic ,nAChRalpha2 Acetylcholine Receptor ,nAChRalpha3 alpha6,nicotinic ,nAChRalpha5 Acetylcholine Receptor ,nAChRalpha6 alpha7,NMDA receptor Cellular plasma membrane ,nAChRalpha7 2,uncharacterized Over-expressed 48 AEL 1301 component receptor complex GO:0098802 1.30E-05 4.75 15 42 4.46 35.7% 1.2% ,Nmdar2 protein Autophagy-related 1,Autophagy-related 101,Autophagy-related 13,Autophagy-related 17,Autophagy-related 18a,Autophagy-related Atg1,Atg101, 18b,Autophagy-related Atg13,Atg17, 6,Phosphotidylinositol 3 Atg18a,Atg18 kinase Cellular phagophore assembly b,Atg6,CG544 59F,uncharacterized Over-expressed 48 AEL 1301 component site GO:0000407 1.80E-05 9.57 9 17 1.8 52.9% 0.7% 5,Pi3K59F protein

Arrestin 1,Arrestin 2,G protein beta-subunit 76C,inactivation no afterpotential C,neither inactivation nor afterpotential C,Phosphatidylinositol 4- phosphate 5-kinase at 59B,retinal Arr1,Arr2,Gbe degeneration ta76C,inaC,ni B,retinophilin,Rhodopsi naC,PIP5K59B n 5,Rhodopsin Cellular ,rdgB,Rh5,Rh 6,transient receptor Over-expressed 48 AEL 1301 component rhabdomere GO:0016028 1.00E-04 5.2 11 29 3.08 37.9% 0.8% 6,rtp,trpl potential-like Autophagy-related 1,Autophagy-related 101,Autophagy-related Cellular Atg1/ULK1 kinase Atg1,Atg101, 13,Autophagy-related Over-expressed 48 AEL 1301 component complex GO:1990316 0.00013 Inf 4 4 0.42 100.0% 0.3% Atg13,Atg17 17 5-hydroxytryptamine (serotonin) receptor 1A,Calbindin 53E,derailed,Dopamine 1-like receptor 1,furry,futsch,Gustatory receptor 33a,Gustatory receptor 39a,Gustatory receptor 94a,headcase,Ionotropi c receptor 25a,Ionotropic receptor 76b,nicotinic 5- Acetylcholine Receptor HT1A,Cbp53E, alpha7,nudE,Octopami Dop1R1,drl,fr ne receptor in y,futsch,Gr33 mushroom a,Gr39a,Gr94 bodies,Odorant a,hdc,Ir25a,Ir receptor 76b,nAChRalp 82a,plum,Resistant to ha7,nudE,Oa dieldrin,Shaker cognate mb,Or82a,plu w,Tissue inhibitor of m,Rdl,Shaw,T metalloproteases,trans Cellular imp,trpl,unc- ient receptor potential- Over-expressed 48 AEL 1301 component dendrite GO:0030425 0.00016 2.73 22 91 9.65 24.2% 1.7% 104 like,uncoordinated-104 Actbeta,Adgf- Activin-beta,Adenosine D,ALiX,amn,A deaminase-related nce- growth factor D,ALG-2 4,AttA,AttB,A interacting protein ttC,AttD,beat- X,amnesiac,Ance- Ia,Burs,CCHa1 4,Attacin-A,Attacin- ,CecA1,CecA2, B,Attacin-C,Attacin- CG10031,CG1 D,beaten path 0433,CG1073 Ia,Bursicon,CCHamide- 0,CG10918,C 1,Cecropin A1,Cecropin G11131,CG11 A2,Chemosensory 852,CG12896, protein B CG13837,CG1 42c,crimpy,Cuticular 4457,CG1552, protein 100A,Cuticular CG16995,CG1 protein 49Af,Cuticular 7843,CG1806 protein 67B,Cuticular 7,CG18135,C protein 76Bb,Cuticular G2650,CG322 protein 97Eb,dally- 06,CG33985,C like,defective proboscis G34402,CG49 extension response 82,CG5267,C 16,Diptericin G5867,CG714 B,Drosocin,Drosomycin, 2,CG8093,CG Ecdysone-inducible 9449,CheB42c gene L2,elevated Cellular ,cmpy,Cpr100 during Over-expressed 48 AEL 1301 component extracellular region GO:0005576 0.00017 1.5 114 783 83.05 14.6% 8.8% A,Cpr49Af,Cpr infection,Follistatin,Gly 5- 5-hydroxytryptamine HT1A,Alk,ana (serotonin) receptor 1,Arr2,Atg8a, 1A,Anaplastic BBS4,Burs,Cb lymphoma p53E,Cc2d2a, kinase,anastral spindle CCKLR- 1,Arrestin 2,Autophagy- 17D1,Cep135, related 8a,Bardet-Biedl cep290,CG11 syndrome 26,CG15666,C 4,Bursicon,Calbindin G15923,CG17 53E,Centrosomal 387,CG32206, protein CG3339,CG34 135kDa,cep290,Cholecy 402,CG5142,C stokinin-like receptor at G9492,CLIP- 17D1,Coiled-coil and C2 190,cmpy,Dhc domain containing 62B,Dhc93AB, 2A,crimpy,Cytoplasmic Dhc98D,Dop1 linker protein R1,dpr11,dpr1 190,defective proboscis 2,dpr18,dpr2, extension response dpr20,dpr4,dp 11,defective proboscis r5,dpr6,drl,dy extension response sc,erm,fry,fut 12,defective proboscis sch,gogo,Gr3 extension response plasma membrane 3a,Gr39a,Gr9 18,defective proboscis Cellular bounded cell 4a,hdc,inaC,Ir extension response Over-expressed 48 AEL 1301 component projection part GO:0120038 0.00018 2.36 28 134 13.76 20.9% 2.2% 25a,Ir76b,kek 2,defective proboscis Anaplastic lymphoma kinase,Autophagy- related 8a,borderless,Bursicon, Calbindin 53E,Cholecystokinin- like receptor at Alk,Atg8a,bdl, 17D1,crimpy,Cytoplasm Burs,Cbp53E, ic linker protein CCKLR- 190,derailed,Disabled,D 17D1,CG4415 own syndrome cell 3,CLIP- adhesion molecule 190,cmpy,Dab 2,Down syndrome cell ,drl,Dscam2,D adhesion molecule scam3,Dscam 3,Down syndrome cell 4,erm,fry,futs adhesion molecule ch,gogo,Gr33 4,earmuff,Ecdysone- a,Gr39a,Gr94 inducible gene a,hdc,ImpL2,I L2,furry,futsch,golden nR,kek6,nudE, goal,Gustatory receptor plum,Ptp99A, 33a,Gustatory receptor Rab3- 39a,Gustatory receptor GEF,rad,Rdl,S 94a,headcase,Insulin- haw,Syt7,Tri like Cellular m9,unc- receptor,kek6,nudE,plu Over-expressed 48 AEL 1301 component axon GO:0030424 0.00019 2.1 36 184 19.52 19.6% 2.8% 104,unc-13 m,Protein tyrosine 5-hydroxytryptamine (serotonin) receptor 1A,Calbindin 53E,Cholecystokinin- like receptor at 17D1,derailed,Dopamin e 1-like receptor 1,earmuff,furry,futsch, Gustatory receptor 5- 33a,Gustatory receptor HT1A,Cbp53E, 39a,Gustatory receptor CCKLR- 94a,headcase,hikaru 17D1,Dop1R1, genki,Ionotropic drl,erm,fry,fut receptor 25a,Ionotropic sch,Gr33a,Gr receptor 76b,nicotinic 39a,Gr94a,hd Acetylcholine Receptor c,hig,Ir25a,Ir7 alpha7,nudE,Octopami 6b,nAChRalph ne receptor in a7,nudE,Oam mushroom b,Or82a,PICK1 bodies,Odorant ,plum,Rab18, receptor Rab3- 82a,plum,Protein GEF,Rab39,R interacting with C abX4,rad,Rdl, kinase 1,Rab18,Rab3 Cellular somatodendritic Shaw,SK,Tim GDP-GTP exchange Over-expressed 48 AEL 1301 component compartment GO:0036477 0.00019 2.2 32 157 16.65 20.4% 2.5% p,trpl,unc-104 factor,Rab39,RabX4,rad Actbeta,Adgf- Activin-beta,Adenosine D,amn,Ance- deaminase-related 4,AttA,AttB,A growth factor ttC,AttD,Burs, D,amnesiac,Ance- CCHa1,CecA1, 4,Attacin-A,Attacin- CecA2,CG100 B,Attacin-C,Attacin- 31,CG10433,C D,Bursicon,CCHamide- G10730,CG10 1,Cecropin A1,Cecropin 918,CG11131, A2,Chemosensory CG11852,CG1 protein B 42c,Diptericin 2896,CG1445 B,Drosomycin,Ecdysone- 7,CG1552,CG inducible gene 16995,CG178 L2,elevated during 43,CG18067,C infection,Glycoprotein G18135,CG26 hormone beta 50,CG32206,C 5,Immune induced G34402,CG49 molecule 82,CG5267,C prepropeptide,Insulin- G5867,CG642 like peptide 3,lectin- 1,CG7142,CG 46Ca,lectin- 8093,CG9449, 46Cb,listericin,Neural CheB42c,DptB Lazarillo,obstructor- ,Drs,edin,Gpb G,obstructor-H,Odorant 5,Ilp3,ImpL2,I receptor Cellular MPPP,lectin- 82a,Peptidoglycan Over-expressed 48 AEL 1301 component extracellular space GO:0005615 0.00025 1.68 67 415 44.02 16.1% 5.1% 46Ca,lectin- recognition protein 5- 5-hydroxytryptamine HT1A,Alk,Atg (serotonin) receptor 8a,bdl,Burs,C 1A,Anaplastic bp53E,CCKLR- lymphoma 17D1,CG1070 kinase,Autophagy- 2,CG32206,C related G34402,CG44 8a,borderless,Bursicon, 153,ChAT,CLIP-Calbindin 190,cmpy,Dab 53E,Cholecystokinin- ,Dop1R1,dpr1 like receptor at 1,dpr12,dpr18 17D1,Choline ,dpr2,dpr20,d acetyltransferase,crimp pr4,dpr5,dpr6, y,Cytoplasmic linker drl,Dscam2,D protein 190,defective scam3,Dscam proboscis extension 4,dysc,erm,fry response 11,defective ,futsch,GluCla proboscis extension lpha,gogo,Gr3 response 12,defective 3a,Gr39a,Gr9 proboscis extension 4a,Grd,hdc,Im response 18,defective pL2,InR,Ir25a, proboscis extension Ir76b,kek6,Kif response 2,defective 3C,nAChRalph proboscis extension a2,nAChRalph response 20,defective Cellular a3,nAChRalph proboscis extension Over-expressed 48 AEL 1301 component neuron projection GO:0043005 0.00051 3.49 13 46 4.71 28.3% 1.0% a5,nAChRalph response 4,defective Dynein heavy chain at 62B,Dynein heavy chain CG3339,CG51 at 89D,Dynein heavy 42,CG9492,Dh chain at Cellular c62B,Dhc93A 93AB,uncharacterized Over-expressed 48 AEL 1301 component axoneme part GO:0044447 0.00074 8.48 6 12 1.27 50.0% 0.5% B,Dhc98D protein

anastral spindle 1,Bardet-Biedl syndrome 4,Centrosomal protein 135kDa,cep290,Coiled- coil and C2 domain containing 2A,Dynein ana1,BBS4,Cc heavy chain at 2d2a,Cep135, 62B,Dynein heavy chain cep290,CG11 at 89D,Dynein heavy 26,CG15666,C chain at G15923,CG17 93AB,dyschronic,mulet, 387,CG3339,C Outer segment G5142,CG949 2,reduced 2,Dhc62B,Dhc mechanoreceptor 93AB,Dhc98D, potential Cellular dysc,mlt,Oseg A,uncharacterized Over-expressed 48 AEL 1301 component ciliary part GO:0044441 9.00E-04 4.55 9 26 2.73 34.6% 0.7% 2,rempA protein alien,Ance,An alien,Ance- ce- 2,Angiotensin 2,CalpC,CG10 converting 602,CG10764, enzyme,Calpain CG11911,CG1 C,Derlin- 1912,CG1225 1,gammaTrypsin,Heat 6,CG1304,CG shock 70-kDa protein 13744,CG152 cognate 3,Jonah 53,CG15254,C 25Bi,Jonah 25Bii,Jonah G15255,CG15 25Biii,Jonah 44E,kelch 485,CG1632,C like family member G17134,CG17 10,lambdaTry,lethal (2) 337,CG17571, k05911,Nardilysin,Nedd CG17633,CG1 8,Notopleural,pomp,pr 8477,CG2915, enyl protease type CG30025,CG3 I,Proteasome alpha4 0031,CG3037 subunit,Proteasome 1,CG30382,C alpha5 G31267,CG31 subunit,Proteasome 269,CG31780, alpha6 CG31954,CG3 subunit,Proteasome 2376,CG3237 alpha7 9,CG33459,C subunit,Proteasome G3355,CG401 beta4 Under-expressed 48 Biological 7,CG42264,C subunit,Regulatory AEL 1726 process proteolysis GO:0006508 1.60E-20 2.39 201 703 108.96 28.6% 11.6% G43124,CG43 particle non-ATPase amd,Ccp84Aa alpha methyl dopa- ,Ccp84Ab,Ccp resistant,Ccp84Aa,Ccp8 84Ac,Ccp84Ad 4Ab,Ccp84Ac,Ccp84Ad, ,Ccp84Af,CG3 Ccp84Af,Chitinase 4461,CG3446 5,Chitinase 9,Coat 2,Cht5,Cht9,ck Protein (coatomer) ,Cpr12A,Cpr23 gamma,crinkled,Cuticul B,Cpr30F,Cpr3 ar protein 12A,Cuticular 5B,Cpr47Eb,C protein 23B,Cuticular pr47Ec,Cpr47 protein 30F,Cuticular Ed,Cpr49Ac,C protein 35B,Cuticular pr49Ad,Cpr49 protein 47Eb,Cuticular Ag,Cpr49Ah,C protein 47Ec,Cuticular pr51A,Cpr5C,C protein 47Ed,Cuticular pr60D,Cpr64A protein 49Ac,Cuticular b,Cpr64Ad,Cpr protein 49Ad,Cuticular 65Ea,Cpr65Eb protein 49Ag,Cuticular ,Cpr65Ec,Cpr6 protein 49Ah,Cuticular 6Cb,Cpr66D,C protein 51A,Cuticular pr67Fa2,Cpr6 protein 5C,Cuticular 7Fb,Cpr78Cb, protein 60D,Cuticular CrebA,dpy,dsx-protein 64Ab,Cuticular c73A,exp,gam protein 64Ad,Cuticular maCOP,Gld,k protein 65Ea,Cuticular Under-expressed 48 Biological chitin-based cuticle nk,Lcp2,Lcp4,L protein 65Eb,Cuticular AEL 1726 process development GO:0040003 1.90E-20 4.96 73 157 24.33 46.5% 4.2% cp65Ab1,Lcp6 protein 65Ec,Cuticular Caf1- CDC45L,Cdc6,Chromatin 180,CDC45L,C assembly factor 1, dc6,Cdk1,CG1 p180 0336,CG1178 subunit,Chromosome 8,CG13690,C transmission fidelity G2990,CG343 4,Cyclin E,Cyclin- 0,Ctf4,CycE,D dependent kinase NA- 1,disc proliferation ligI,DNApol- abnormal,DNA ligase alpha180,DN I,DNA polymerase Apol- alpha 180kD,DNA alpha50,DNA polymerase alpha pol- 50kD,DNA polymerase alpha60,DNA alpha 60kD,DNA pol- polymerase alpha alpha73,DNA 73kD,DNA polymerase pol- epsilon 255kD epsilon255,D subunit,DNA NApol- polymerase epsilon epsilon58,dpa 58kD subunit,double ,dup,Fen1,ge parked,Flap minin,hd,Mc endonuclease m10,Mcm2,M 1,geminin,humpty cm3,Mcm5,M dumpty,Minichromoso Under-expressed 48 Biological cm6,Mcm7,m me maintenance AEL 1726 process DNA replication GO:0006260 1.50E-11 4.2 45 105 16.27 42.9% 2.6% us308,Orc1,O 10,Minichromosome CDC45L,Cdc6,Cyclin- dependent kinase 1,disc proliferation abnormal,DNA polymerase alpha 180kD,DNA polymerase alpha 73kD,Minichromosome maintenance 10,Minichromosome maintenance 2,Minichromosome maintenance 3,Minichromosome maintenance CDC45L,Cdc6, 5,Minichromosome Cdk1,DNApol- maintenance alpha180,DN 6,Minichromosome Apol- maintenance 7,Origin alpha73,dpa, recognition complex Mcm10,Mcm subunit 1,Origin 2,Mcm3,Mcm recognition complex 5,Mcm6,Mcm subunit 2,Origin 7,Orc1,Orc2,O recognition complex Under-expressed 48 Biological DNA replication rc3,Orc5,Orc6 subunit 3,Origin AEL 1726 process initiation GO:0006270 3.70E-11 19.88 18 23 3.56 78.3% 1.0% ,Rif1 recognition complex GTP-binding protein,Sec61 alpha subunit,Sec61 beta subunit,Secretory 63,Signal recognition particle protein 14,Signal recognition particle protein 19,Signal recognition particle protein 54k,Signal recognition particle protein 68,Signal recognition particle protein 72,Signal recognition particle protein 9,small CG5885,Gtp- glutamine-rich bp,Sec61alph tetratricopeptide a,Sec61beta,S containing ec63,Sgt,Spas protein,Spase 12- e12,Spase22- subunit,Spase 22/23- 23,Spase25,Sr subunit,Spase 25- establishment of p14,Srp19,Srp subunit,TRAM,Transloc protein localization to 54k,Srp68,Srp ation protein Under-expressed 48 Biological endoplasmic 72,Srp9,TRA 1,uncharacterized AEL 1726 process reticulum GO:0072599 1.90E-10 18.76 17 22 3.41 77.3% 1.0% M,Trp1 protein Proteasome alpha2 subunit,Proteasome alpha3 subunit,Proteasome alpha4 subunit,Proteasome alpha5 subunit,Proteasome alpha6 subunit,Proteasome alpha7 subunit,Proteasome beta1 subunit,Proteasome Prosalpha2,Pr beta2 osalpha3,Pros subunit,Proteasome alpha4,Prosal beta3 pha5,Prosalph subunit,Proteasome a6,Prosalpha7 beta4 ,Prosbeta1,Pr subunit,Proteasome osbeta2,Prosb beta5 eta3,Prosbeta subunit,Proteasome proteasomal ubiquitin- 4,Prosbeta5,P beta6 Under-expressed 48 Biological independent protein rosbeta6,Pros subunit,Proteasome AEL 1726 process catabolic process GO:0010499 2.20E-09 35.78 13 15 2.32 86.7% 0.8% beta7 beta7 subunit boca,Calnexin 99A,Calreticulin,Canopy b,Chaperonin containing TCP1 subunit 1,Chaperonin boca,Calr,CCT containing TCP1 1,CCT2,CCT3,C subunit 2,Chaperonin CT5,CCT7,CCT containing TCP1 8,CG11267,C subunit 3,Chaperonin G16817,CG17 containing TCP1 266,CG2852,C subunit 5,Chaperonin G3678,CG787 containing TCP1 2,CNPYb,Cnx9 subunit 7,Chaperonin 9A,Cyp1,Cypl, containing TCP1 EMC1,EMC3,E subunit 8,Cyclophilin Rp60,FK506- 1,Cyclophilin-like,ER bp2,FKBP59,G Membrane protein p93,HIP,HIP- Complex 1,ER R,Hsc70- Membrane protein 3,Hsp67Ba,Hs Complex p68,Hsp70Ba, 3,ERp60,FK506-binding l(2)efl,Nrd1,n protein 2,FK506- udC,P58IPK,Pd binding protein i,Pfdn5,Pfdn6, FKBP59,Glycoprotein Under-expressed 48 Biological sel,Sgt,shv,To 93,Heat shock 70-kDa AEL 1726 process protein folding GO:0006457 3.40E-07 3.97 27 65 10.01 41.5% 1.6% rsin,wbl protein cognate 3,Heat

ADP ribosylation factor- like 1,baiser,boca,CHOp24,C oat Protein (coatomer) alpha,Coat Protein (coatomer) beta,Coat alphaCOP,Arl Protein (coatomer) 1,bai,beta'CO beta',Coat Protein P,betaCOP,bo (coatomer) delta,Coat ca,CG32069,C Protein (coatomer) G4293,CG548 epsilon,Coat Protein 4,CG5510,CG (coatomer) 7011,CG9175, gamma,eclair,ergic53,K CHOp24,delta DEL COP,eca,epsil receptor,logjam,memb onCOP,ergic5 rin,p115,p24-related- 3,gammaCOP 1,p24-related- ,KdelR,loj,Me 2,Secretory mbrin,p115,p 13,Secretory 24-1,p24- 22,Secretory 2,Sec13,Sec2 23,Secretory Under-expressed 48 Biological ER to Golgi vesicle- 2,Sec23,Sec2 24CD,uncharacterized AEL 1726 process mediated transport GO:0006888 4.20E-07 3.78 28 69 10.69 40.6% 1.6% 4CD protein

Chromatin assembly factor 1, p55 subunit,Cyclin E,double parked,geminin,humpty dumpty,Minichromoso me maintenance 6,Myb- Caf1- interacting protein 55,CycE,dup,g 40,Origin recognition eminin,hd,Mc complex subunit m6,mip40,Or 2,piccolo,Proliferating Under-expressed 48 Biological eggshell chorion gene c2,PCNA,pic,R cell nuclear AEL 1726 process amplification GO:0007307 5.20E-05 6.71 11 20 3.1 55.0% 0.6% ecQ4 antigen,RecQ4 helicase Tb,TwdlB,Tw dlbeta,TwdlD, Tubby,TweedleB,Twee TwdlG,TwdlM dlebeta,TweedleD,Twe ,TwdlR,TwdlS edleG,TweedleM,Twee ,TwdlT,Twdl dleR,TweedleS,Tweedl Under-expressed 48 Biological W,TwdlX,Twd eT,TweedleW,Tweedle AEL 1726 process body morphogenesis GO:0010171 8.00E-05 5.49 12 24 3.72 50.0% 0.7% lY X,TweedleY GTP-binding protein,Sec61 alpha subunit,Sec61 beta subunit,Secretory 63,Signal recognition particle protein 14,Signal recognition particle protein 19,Signal recognition particle protein 54k,Signal recognition CG5885,Gtp- particle protein bp,Sec61alph 68,Signal recognition a,Sec61beta,S particle protein SRP-dependent ec63,Srp14,Sr 72,Signal recognition cotranslational protein p19,Srp54k,Sr particle protein Under-expressed 48 Biological targeting to p68,Srp72,Srp 9,TRAM,uncharacterize AEL 1726 process membrane GO:0006614 8.20E-05 33 6 7 1.08 85.7% 0.3% 9,TRAM d protein AIF,Alg10,alp Alpha 3 ha- glucosyltransferase,Ant PheRS,ArgRS, ioxidant 1 copper Atox1,Btnd,Ca chaperone,Apoptosis lpC,CG11911, inducing factor,Arginyl- CG11912,CG1 tRNA 2256,CG1304, synthetase,Biotinidase, CG15343,CG1 Calpain C,Catalytic 632,CG1885,C subunit 3A of the G30008,CG30 oligosaccharyltransfera 025,CG30031, se complex,Chitinase CG30291,CG3 10,Cyclophilin 0382,CG3049 1,dachsous,Derlin- 6,CG31267,C 1,dodo,Heat shock 70- G31269,CG31 kDa protein cognate 780,CG31917, 3,Jonah 25Bi,Jonah CG31954,CG3 25Bii,Jonah 25Biii,kelch 2276,CG3228 like family member 4,CG32376,C 10,lesswright,mitochon G32379,CG33 drial ribosomal protein 303,CG33459, L10,mitochondrial CG3355,CG39 ribosomal protein 64,CG4020,C L14,mitochondrial organonitrogen G42264,CG43 ribosomal protein Under-expressed 48 Biological compound metabolic 124,CG43125, L16,mitochondrial AEL 1726 process process GO:1901564 8.20E-05 1.27 477 2693 417.41 17.7% 27.6% CG4678,CG48 ribosomal protein Sec61 alpha subunit,Sec61 beta subunit,Signal recognition particle SRP-dependent protein 19,Signal cotranslational protein Sec61alpha,S recognition particle targeting to ec61beta,Srp protein 72,Signal Under-expressed 48 Biological membrane, 19,Srp72,Srp9 recognition particle AEL 1726 process translocation GO:0006616 8.30E-05 32.85 6 7 1.08 85.7% 0.3% ,TRAM protein 9,TRAM

Regulatory particle triple-A ATPase 1,Regulatory particle triple-A ATPase 3,Regulatory particle triple-A ATPase 3- related,Regulatory positive regulation of particle triple-A ATPase RNA polymerase II 4,Regulatory particle transcriptional Rpt1,Rpt3,Rpt triple-A ATPase Under-expressed 48 Biological preinitiation complex 3R,Rpt4,Rpt5, 5,Regulatory particle AEL 1726 process assembly GO:0045899 8.30E-05 32.85 6 7 1.08 85.7% 0.3% Rpt6 triple-A ATPase 6 Alpha 3 glucosyltransferase,Cat alytic subunit 3A of the oligosaccharyltransfera se complex,Catalytic subunit 3B of the oligosaccharyltransfera se complex,Defender against apoptotic cell death 1,medial glomeruli,O- Alg10,CG1016 fucosyltransferase 6,CG11149,C 1,Oligosaccharide G32276,CG33 transferase Delta 303,CG33774, subunit,Oligosaccharid CG33977,CG3 e transferase gamma 4452,CG3792, subunit,Oligosaccharylt CG7840,CG87 ransferase 48kD 08,CG9669,Da subunit,Pabp2,polypept d1,meigo,O- ide GalNAc transferase fut1,Ost48,Os 3,rotated tDelta,Ostga abdomen,rumi,twisted, mma,Pabp2,p UDP-glucose- gant3,rt,rumi, glycoprotein Under-expressed 48 Biological macromolecule Stt3A,Stt3B,t glucosyltransferase,unc AEL 1726 process glycosylation GO:0043413 1.00E-04 2.62 27 84 13.02 32.1% 1.6% w,Ugt,wol haracterized

ADP ribosylation factor- like 1,baiser,CHOp24,eclair, ergic53,Golgi pH Regulator,Grasp65,logj Arl1,bai,CG10 am,mitochondrial 738,CG13049, translation elongation CG13284,CG1 factor Tu 6817,CG5510, 1,Oligosaccharyltransfe CG7456,CHOp rase 48kD 24,eca,ergic5 subunit,p115,p24- 3,GPHR,Grasp related-1,p24-related- 65,loj,mEFTu 2,rumi,Secretory 1,Ost48,p115, 23,Secretory p24-1,p24- 24CD,string,TER94,Tran 2,rumi,Sec23, sport and Golgi Sec24CD,stg,T organization Under-expressed 48 Biological ango2,TER94, 2,uncharacterized AEL 1726 process Golgi organization GO:0007030 0.00017 2.56 26 82 12.71 31.7% 1.5% wol protein,wollknaeuel Alpha 3 glucosyltransferase,bet a-4- galactosyltransferase 7,Catalytic subunit 3A of the oligosaccharyltransfera se complex,Catalytic subunit 3B of the Alg10,beta4G oligosaccharyltransfera alT7,CG10166 se complex,Defender ,CG11149,CG against apoptotic cell 32276,CG333 death 1,medial 03,CG33774,C glomeruli,O- G33977,CG34 fucosyltransferase 452,CG3792,C 1,Oligosaccharide G7840,CG870 transferase Delta 8,CG9669,Dad subunit,Oligosaccharid 1,meigo,O- e transferase gamma fut1,Ost48,Os subunit,Oligosaccharylt tDelta,Ostga ransferase 48kD mma,Pabp2,P subunit,Pabp2,PAPS apst2,pgant3, transporter rt,rumi,sll,Stt 2,polypeptide GalNAc Under-expressed 48 Biological glycoprotein 3A,Stt3B,tw, transferase 3,rotated AEL 1726 process biosynthetic process GO:0009101 0.00017 2.37 30 100 15.5 30.0% 1.7% Ugt,wol abdomen,rumi,slalom,t

DNA ligase I,DNA polymerase alpha 180kD,DNA polymerase epsilon 255kD CG13690,CG2 subunit,Flap 990,DNA- endonuclease ligI,DNApol- 1,Proliferating cell alpha180,DN nuclear Apol- antigen,Psf1,Replicatio DNA strand elongation epsilon255,Fe n factor C 38kD Under-expressed 48 Biological involved in DNA n1,PCNA,Psf1, subunit,uncharacterize AEL 1726 process replication GO:0006271 2.00E-04 7.05 9 16 2.48 56.2% 0.5% RfC38 d protein boca,GTP-binding protein,membrin,Sec61 alpha subunit,Sec61 beta subunit,Sec61 gamma subunit,Secretory 63,Signal recognition particle protein 14,Signal recognition boca,CG1427 particle protein 0,CG34132,C 19,Signal recognition G5885,CG886 particle protein 0,Gtp- 54k,Signal recognition bp,Membrin,S particle protein ec61alpha,Se 68,Signal recognition c61beta,Sec6 particle protein 1gamma,Sec 72,Signal recognition 63,Sgt,Spase1 particle protein 9,small 2,Spase22- glutamine-rich 23,Spase25,Sr tetratricopeptide p14,Srp19,Srp containing 54k,Srp68,Srp protein,Spase 12- 72,Srp9,Tim8, subunit,Spase 22/23- Tim9a,Tim9b, subunit,Spase 25- Under-expressed 48 Biological Tom70,TRAM subunit,Tim8,Tim9a,tin AEL 1726 process protein targeting GO:0006605 0.00022 2.42 28 92 14.26 30.4% 1.6% ,Trp1,ttm50 y tim Derlin-1,F-box and CG30382,Der- leucine-rich repeat 1,Fbxl7,Hsc70- protein 7,Heat shock 70- 3,ida,pic,Plap, kDa protein cognate Pomp,Prosalp 3,imaginal discs ha2,Prosalpha arrested,Phospholipase 3,Prosalpha4, A2 activator Prosalpha5,Pr protein,piccolo,pomp,Pr osalpha6,Pros oteasome alpha2 alpha7,Prosbe subunit,Proteasome ta1,Prosbeta2 alpha3 ,Prosbeta3,Pr subunit,Proteasome osbeta4,Prosb alpha4 eta5,Prosbeta subunit,Proteasome 6,Prosbeta7,R alpha5 pn1,Rpn10,Rp subunit,Proteasome n11,Rpn12,Rp alpha6 n2,Rpn3,Rpn5 subunit,Proteasome ,Rpn7,Rpn8,R alpha7 pn9,Rpt1,Rpt subunit,Proteasome 2,Rpt3,Rpt3R, beta1 Rpt4,Rpt5,Rpt subunit,Proteasome proteasome-mediated 6,Sec13,Sem1 beta2 ubiquitin-dependent ,Sgt,sip3,Skp2 subunit,Proteasome Under-expressed 48 Biological protein catabolic ,TER94,Uch- beta3 AEL 1726 process process GO:0043161 0.00022 1.93 46 178 27.59 25.8% 2.7% L5,Usp5 subunit,Proteasome

CDC45L,Chromatin assembly factor 1, p55 subunit,Cyclin E,DNA ligase I,DNA polymerase epsilon 58kD subunit,double parked,geminin,humpty dumpty,Minichromoso me maintenance 6,Myb- Caf1- interacting protein 55,CDC45L,Cy 40,Origin recognition cE,DNA- complex subunit ligI,DNApol- 1,Origin recognition epsilon58,dup complex subunit ,geminin,hd, 2,piccolo,Proliferating Mcm6,mip40, cell nuclear Orc1,Orc2,PC antigen,RecQ4 Under-expressed 48 Biological DNA biosynthetic NA,pic,RecQ4 helicase,Replication AEL 1726 process process GO:0071897 0.00031 3.38 16 42 6.51 38.1% 0.9% ,RPA2 protein A2 Alpha 3 glucosyltransferase,Cat alytic subunit 3B of the oligosaccharyltransfera se complex,Defender against apoptotic cell death 1,medial glomeruli,Oligosacchari de transferase Delta subunit,Oligosaccharid Alg10,CG3330 e transferase gamma 3,CG33774,C subunit,Oligosaccharylt G7840,CG966 ransferase 48kD 9,Dad1,meigo subunit,UDP-glucose- ,Ost48,OstDel glycoprotein ta,Ostgamma glucosyltransferase,unc Under-expressed 48 Biological protein N-linked ,Stt3B,Ugt,wo haracterized AEL 1726 process glycosylation GO:0006487 0.00037 3.97 13 31 4.8 41.9% 0.8% l protein,wollknaeuel CG30427,CG4 Fatty acyl-CoA 020,CG5065,C reductase in Under-expressed 48 Biological wax biosynthetic G8303,CG830 oenocytes,uncharacteri AEL 1726 process process GO:0010025 0.00039 9.59 7 11 1.7 63.6% 0.4% 6,FarO,wat zed protein,waterproof Sec61 alpha subunit,Sec61 beta subunit,Secretory 63,small glutamine- posttranslational rich tetratricopeptide protein targeting to Sec61alpha,S containing Under-expressed 48 Biological endoplasmic ec61beta,Sec protein,Translocation AEL 1726 process reticulum membrane GO:0006620 0.00046 27.36 5 6 0.93 83.3% 0.3% 63,Sgt,Trp1 protein 1

Canopy b,FK506- binding protein 2,FK506- binding protein FKBP59,Heat shock 70- kDa protein cognate 3,Heat shock gene 67Ba,Heat shock protein 68,Heat-shock- protein- 70Ba,Hsc/Hsp70- interacting protein,Hsc/Hsp70- CG11267,CNP interacting protein Yb,FK506- related,lethal (2) bp2,FKBP59,H essential for IP,HIP- life,Nardilysin,seele,sm R,Hsc70- all glutamine-rich 3,Hsp67Ba,Hs tetratricopeptide p68,Hsp70Ba, containing Under-expressed 48 Biological chaperone-mediated l(2)efl,Nrd1,s protein,torsin,uncharac AEL 1726 process protein folding GO:0061077 0.00057 3.3 15 40 6.2 37.5% 0.9% el,Sgt,Torsin terized protein bai,CHOp24,e baiser,CHOp24,eclair,lo Under-expressed 48 Biological regulation of post- ca,loj,p24- gjam,p24-related-1,p24- AEL 1726 process mating oviposition GO:0048042 0.00075 10.95 6 9 1.39 66.7% 0.3% 1,p24-2 related-2 ATPCL,CG102 68,CG30427,C G33671,CG40 20,CG5065,C ATP citrate lyase,Fatty G8239,CG830 acyl-CoA reductase in 3,CG8306,Far oenocytes,scully,sucb,u Under-expressed 48 Biological acyl-CoA metabolic O,scu,Sucb,w ncharacterized AEL 1726 process process GO:0006637 0.00077 3.57 13 33 5.11 39.4% 0.8% at protein,waterproof CG30427,CG4 Fatty acyl-CoA 020,CG5065,C reductase in Under-expressed 48 Biological long-chain fatty-acyl- G8303,CG830 oenocytes,uncharacteri AEL 1726 process CoA metabolic process GO:0035336 0.00082 7.67 7 12 1.86 58.3% 0.4% 6,FarO,wat zed protein,waterproof Adgf- abnormal wing C,Adk3,AIF,Al discs,Adenosine g10,ATPCL,aw deaminase-related d,beta4GalT7, growth factor CG10166,CG1 C,Adenylate kinase 0268,CG1047 3,Alpha 3 4,CG10738,C glucosyltransferase,Ap G11149,CG11 optosis inducing 164,CG12009, factor,ATP citrate CG13675,CG1 lyase,beta-4- 3676,CG1380 galactosyltransferase 6,CG14291,C 7,Catalytic subunit 3A G14304,CG14 of the 880,CG17145, oligosaccharyltransfera CG30427,CG3 se complex,Catalytic 2276,CG3228 subunit 3B of the 4,CG33303,C oligosaccharyltransfera G33671,CG33 se complex,Chitinase 774,CG33977, 10,Chitinase CG34282,CG3 5,Chitinase 9,Defender 788,CG3792,C against apoptotic cell G4020,CG430 death 2,CG5065,CG 1,deoxyribonucleoside carbohydrate 5167,CG5613, kinase,Deoxyuridine Under-expressed 48 Biological derivative metabolic CG7840,CG82 triphosphatase,expansi AEL 1726 process process GO:1901135 0.00097 1.43 112 550 85.25 20.4% 6.5% 39,CG8303,C on,GDP-4-keto-6-deoxy- Ance,Ance- Ance-2,Ance- 2,Ance- 5,Angiotensin 5,CalpC,CG10 converting 472,CG10602, enzyme,Calpain CG10764,CG1 C,gammaTrypsin,Jonah 1911,CG1191 25Bi,Jonah 25Bii,Jonah 2,CG12256,C 25Biii,Jonah 44E,Jonah G1304,CG137 65Ai,Jonah 65Aii,Jonah 44,CG14820,C 65Aiii,Jonah G15253,CG15 65Aiv,Jonah 66Ci,Jonah 254,CG15255, 66Cii,lambdaTry,lethal CG15485,CG1 (2) 6998,CG1713 k05911,Nardilysin,Noto 4,CG17337,C pleural,prenyl protease G17571,CG17 type I,Proteasome 633,CG2915,C alpha3 G30025,CG30 subunit,Proteasome 031,CG30371, alpha4 CG30382,CG3 subunit,Proteasome 1267,CG3126 alpha5 9,CG31780,C subunit,Proteasome G31954,CG32 alpha6 374,CG32376, subunit,Proteasome peptidase activity, CG32379,CG3 alpha7 Under-expressed 48 Molecular acting on L-amino acid 344,CG33459, subunit,Proteasome AEL 1726 function peptides GO:0070011 5.70E-21 3.71 102 261 40.57 39.1% 5.9% CG33465,CG3 beta4 CG10472,CG1 0764,CG1183 6,CG11842,C G11843,CG11 911,CG11912, CG12256,CG1 304,CG13744, CG16749,CG1 6998,CG1747 deltaTrypsin,easter,eps 5,CG17477,C ilonTrypsin,gammaTryp G17571,CG30 sin,Jonah 25Bi,Jonah 025,CG30031, 25Bii,Jonah CG30371,CG3 25Biii,Jonah 44E,Jonah 1266,CG3126 65Ai,Jonah 65Aii,Jonah 7,CG31269,C 65Aiii,Jonah G31780,CG31 65Aiv,Jonah 66Ci,Jonah 954,CG32374, 66Cii,Jonah 74E,Jonah CG32376,CG3 99Cii,Jonah 99Ciii,Jonah 3459,CG3346 99Fii,lambdaTry,lethal 5,CG3355,CG (2) 34437,CG344 k05911,Notopleural,Ser 58,CG4053,C ine protease G43124,CG43 6,Stubble,thetaTrypsin, 125,CG4386,C uncharacterized Under-expressed 48 Molecular serine-type G4613,CG491 protein,yippee AEL 1726 function endopeptidase activity GO:0004252 4.10E-18 4.52 70 156 24.67 44.9% 4.1% 4,CG5255,CG interacting protein 7 CG10472,CG1 0764,CG1183 6,CG11842,C G11843,CG11 911,CG11912, CG12256,CG1 304,CG13744, deltaTrypsin,easter,eps CG16749,CG1 ilonTrypsin,gammaTryp 6998,CG1747 sin,Jonah 25Bi,Jonah 5,CG17477,C 25Bii,Jonah G17571,CG30 25Biii,Jonah 44E,Jonah 025,CG30031, 65Ai,Jonah 65Aii,Jonah CG30371,CG3 65Aiii,Jonah 1266,CG3126 65Aiv,Jonah 66Ci,Jonah 7,CG31269,C 66Cii,Jonah 74E,Jonah G31780,CG31 99Cii,Jonah 99Ciii,Jonah 954,CG32374, 99Fii,lambdaTry,lethal CG32376,CG3 (2) 344,CG33459, k05911,Notopleural,Ser CG33465,CG3 ine protease 355,CG34437, 6,Stubble,thetaTrypsin, CG34458,CG3 twisted bristles 734,CG4053,C roughened G43124,CG43 eye,uncharacterized Under-expressed 48 Molecular serine hydrolase 125,CG4386,C protein,yippee AEL 1726 function activity GO:0017171 5.80E-17 3.99 74 177 28 41.8% 4.3% G4613,CG491 interacting protein 7 Ccp84Aa,Ccp84Ab,Ccp8 Ccp84Aa,Ccp8 4Ac,Ccp84Ad,Ccp84Af,C 4Ab,Ccp84Ac, uticular protein Ccp84Ad,Ccp8 12A,Cuticular protein 4Af,CG34461, 23B,Cuticular protein CG34462,Cpr1 30F,Cuticular protein 2A,Cpr23B,Cp 35B,Cuticular protein r30F,Cpr35B,C 47Eb,Cuticular protein pr47Eb,Cpr47 47Ec,Cuticular protein Ec,Cpr47Ed,Cp 47Ed,Cuticular protein r49Ac,Cpr49A 49Ac,Cuticular protein d,Cpr49Ag,Cpr 49Ad,Cuticular protein 49Ah,Cpr51A, 49Ag,Cuticular protein Cpr5C,Cpr60D, 49Ah,Cuticular protein Cpr64Ab,Cpr6 51A,Cuticular protein 4Ad,Cpr65Ea, 5C,Cuticular protein Cpr65Eb,Cpr6 60D,Cuticular protein 5Ec,Cpr66Cb,C 64Ab,Cuticular protein pr66D,Cpr67F 64Ad,Cuticular protein a2,Cpr67Fb,C 65Ea,Cuticular protein pr78Cb,Lcp2,L 65Eb,Cuticular protein cp4,Lcp65Ab1 65Ec,Cuticular protein ,Lcp65Ad,Lcp6 66Cb,Cuticular protein structural constituent 5Af,Lcp65Ag1 66D,Cuticular protein Under-expressed 48 Molecular of chitin-based larval ,Pcp,TwdlD,T 67Fa2,Cuticular protein AEL 1726 function cuticle GO:0008010 4.50E-15 7.05 40 71 11.23 56.3% 2.3% wdlH 67Fb,Cuticular protein Proteasome alpha2 subunit,Proteasome alpha3 subunit,Proteasome alpha4 subunit,Proteasome alpha5 subunit,Proteasome alpha6 subunit,Proteasome alpha7 subunit,Proteasome beta1 subunit,Proteasome CG30382,Pros beta2 alpha2,Prosal subunit,Proteasome pha3,Prosalph beta3 a4,Prosalpha5 subunit,Proteasome ,Prosalpha6,P beta4 rosalpha7,Pro subunit,Proteasome sbeta1,Prosbe beta5 ta2,Prosbeta3 subunit,Proteasome ,Prosbeta4,Pr beta6 osbeta5,Prosb subunit,Proteasome Under-expressed 48 Molecular threonine-type eta6,Prosbeta beta7 AEL 1726 function endopeptidase activity GO:0004298 5.10E-10 37.65 14 16 2.53 87.5% 0.8% 7 subunit,uncharacterize Ccp84Aa,Ccp8 Ccp84Aa,Ccp84Ab,Ccp8 4Ab,Ccp84Ac, 4Ac,Ccp84Ad,Ccp84Af,C Ccp84Ad,Ccp8 uticular protein 4Af,CG34461, 12A,Cuticular protein CG34462,Cpr1 23B,Cuticular protein 2A,Cpr23B,Cp 30F,Cuticular protein r30F,Cpr35B,C 35B,Cuticular protein pr47Eb,Cpr47 47Eb,Cuticular protein Ec,Cpr47Ed,Cp 47Ec,Cuticular protein r49Ac,Cpr49A 47Ed,Cuticular protein d,Cpr49Ag,Cpr 49Ac,Cuticular protein 49Ah,Cpr51A, 49Ad,Cuticular protein Cpr5C,Cpr60D, 49Ag,Cuticular protein Cpr64Ab,Cpr6 49Ah,Cuticular protein 4Ad,Cpr65Ea, 51A,Cuticular protein Cpr65Eb,Cpr6 5C,Cuticular protein 5Ec,Cpr66Cb,C 60D,Cuticular protein pr66D,Cpr67F 64Ab,Cuticular protein a2,Cpr67Fb,C 64Ad,Cuticular protein pr78Cb,dsx- 65Ea,Cuticular protein c73A,Lcp2,Lcp 65Eb,Cuticular protein 4,Lcp65Ab1,Lc 65Ec,Cuticular protein p65Ad,Lcp65A 66Cb,Cuticular protein f,Lcp65Ag1,m 66D,Cuticular protein Under-expressed 48 Molecular structural constituent ,Pcp,Tb,TwdlB 67Fa2,Cuticular protein AEL 1726 function of chitin-based cuticle GO:0005214 5.00E-08 9.83 16 25 3.87 64.0% 0.9% ,Twdlbeta,Tw 67Fb,Cuticular protein

CDC45L,Cdc6,DNA polymerase alpha 180kD,Minichromosom e maintenance 10,Minichromosome maintenance 5,Origin recognition complex subunit 1,Origin recognition complex subunit 2,Origin CDC45L,Cdc6, recognition complex DNApol- subunit 3,Origin alpha180,Mc recognition complex m10,Mcm5,O subunit 5,Origin Under-expressed 48 Molecular DNA replication origin rc1,Orc2,Orc3 recognition complex AEL 1726 function binding GO:0003688 9.00E-08 53.63 10 11 1.74 90.9% 0.6% ,Orc5,Orc6 subunit 6 Act42A,alpha Actin 42A,alpha- COP,alphaTub Tubulin at 84B,alpha- 84B,alphaTub Tubulin at 84D,beta- 84D,betaCOP, Tubulin at betaTub56D,b 56D,bonsai,Ccp84Aa,Cc onsai,Ccp84A p84Ab,Ccp84Ac,Ccp84A a,Ccp84Ab,Cc d,Ccp84Af,Clathrin light p84Ac,Ccp84A chain,Coat Protein d,Ccp84Af,CG (coatomer) alpha,Coat 10602,CG312 Protein (coatomer) 68,CG8771,Cl beta,Coat Protein c,Cpr12A,Cpr2 (coatomer) 3B,Cpr30F,Cpr epsilon,Coat Protein 35B,Cpr47Eb, (coatomer) Cpr47Ec,Cpr4 gamma,Cuticular 7Ed,Cpr49Ac, protein 12A,Cuticular Cpr49Ad,Cpr4 protein 23B,Cuticular 9Ag,Cpr49Ah, protein 30F,Cuticular Cpr51A,Cpr5C, protein 35B,Cuticular Cpr60D,Cpr64 protein 47Eb,Cuticular Ab,Cpr64Ad,C protein 47Ec,Cuticular pr65Ea,Cpr65 protein 47Ed,Cuticular Eb,Cpr65Ec,Cp protein 49Ac,Cuticular r66Cb,Cpr66D, protein 49Ad,Cuticular Under-expressed 48 Molecular structural molecule Cpr67Fa2,Cpr protein 49Ag,Cuticular AEL 1726 function activity GO:0005198 1.70E-07 1.88 106 418 66.11 25.4% 6.1% 67Fb,Cpr78Cb protein 49Ah,Cuticular

Catalytic subunit 3B of the oligosaccharyltransfera se complex,Defender against apoptotic cell death 1,Oligosaccharide transferase Delta subunit,Oligosaccharid dolichyl- CG33303,CG3 e transferase gamma diphosphooligosacchar 3774,Dad1,Os subunit,Oligosaccharylt ide-protein t48,OstDelta, ransferase 48kD Under-expressed 48 Molecular glycotransferase Ostgamma,St subunit,uncharacterize AEL 1726 function activity GO:0004579 2.40E-06 Inf 7 7 1.11 100.0% 0.4% t3B d protein Ance,Ance- 2,Ance- 5,CG14820,C G17337,CG17 633,CG2915,C G32379,CG32 473,CG3344,C G3502,CG373 4,CG4017,CG 42264,CG440 8,CG4678,CG Ance-2,Ance- 4829,CG5188, 5,Angiotensin CG5355,CG70 converting 25,CG7860,C enzyme,Dipeptidyl G8560,CG856 aminopeptidase 2,CG8945,CG III,granny Under-expressed 48 Molecular 9953,DppIII,gr smith,SP1029,uncharac AEL 1726 function exopeptidase activity GO:0008238 8.30E-06 3.09 28 77 12.18 36.4% 1.6% sm,SP1029 terized protein

Alp1,Alp4,CG Alkaline phosphatase 10592,CG167 1,Alkaline phosphatase 71,CG3264,C 4,phurba Under-expressed 48 Molecular alkaline phosphatase G3292,CG515 tashi,uncharacterized AEL 1726 function activity GO:0004035 8.40E-06 16.07 9 12 1.9 75.0% 0.5% 0,CG8105,phu protein

Signal recognition particle protein 14,Signal recognition particle protein 19,Signal recognition particle protein 54k,Signal recognition particle protein 68,Signal recognition Srp14,Srp19,S particle protein Under-expressed 48 Molecular rp54k,Srp68,S 72,Signal recognition AEL 1726 function 7S RNA binding GO:0008312 1.60E-05 Inf 6 6 0.95 100.0% 0.3% rp72,Srp9 particle protein 9

Regulatory particle triple-A ATPase 1,Regulatory particle triple-A ATPase 2,Regulatory particle triple-A ATPase 3,Regulatory particle triple-A ATPase 3- related,Regulatory particle triple-A ATPase 4,Regulatory particle Rpt1,Rpt2,Rpt triple-A ATPase Under-expressed 48 Molecular proteasome-activating 3,Rpt3R,Rpt4, 5,Regulatory particle AEL 1726 function ATPase activity GO:0036402 1.70E-05 37.45 7 8 1.27 87.5% 0.4% Rpt5,Rpt6 triple-A ATPase 6 CG14820,CG1 7633,CG2915, CG32379,CG4 017,CG42264, CG4408,CG46 78,CG7025,C Under-expressed 48 Molecular metallocarboxypeptid G8560,CG856 AEL 1726 function ase activity GO:0004181 1.70E-05 7.15 12 21 3.32 57.1% 0.7% 2,CG8945 uncharacterized protein Ance,Ance- 2,CG10602,C G14527,CG14 820,CG15253, CG15254,CG1 5255,CG1548 5,CG17337,C G17633,CG29 15,CG32379,C G32473,CG35 02,CG4017,C G42264,CG44 08,CG4678,C G5131,CG518 8,CG5715,CG Ance-2,Angiotensin 6696,CG6763, converting CG7025,CG76 enzyme,granny 31,CG8550,C smith,Nardilysin,Nepril G8560,CG856 ysin 2,prenyl protease 2,CG8945,grs type I,Regulatory m,Nep2,Nrd1, particle non-ATPase Under-expressed 48 Molecular metallopeptidase Rpn11,SP102 11,SP1029,stall,unchar AEL 1726 function activity GO:0008237 2.10E-05 2.44 37 119 18.82 31.1% 2.1% 9,ste24a,stl acterized protein alpha- Biotinidase,Calpain PheRS,Btnd,C C,CDC45L,Chitinase alpC,CDC45L,C 10,dachs,Deoxyuridine G11164,CG11 triphosphatase,Derlin- 911,CG11912, 1,eukaryotic translation CG12256,CG1 release factor 3,Fatty 304,CG13690, acid synthase 3,Heat CG15743,CG1 shock 70-kDa protein 7134,CG1763 cognate 3,Helicase at 3,CG18258,C 25E,Jonah 25Bi,Jonah G18641,CG19 25Bii,Jonah 86,CG2990,C 25Biii,Juvenile G30016,CG30 hormone epoxide 025,CG30031, hydrolase 1,Lysosomal CG30382,CG3 alpha-mannosidase 1267,CG3126 V,Maltase 9,CG31780,C B1,Minichromosome G31954,CG32 maintenance 376,CG32379, 3,Minichromosome CG32750,CG3 maintenance 2751,CG3345 6,mitochondrial 9,CG3355,CG translation elongation 4017,CG4223 factor G 7,CG42264,C 1,mulder,mus81,Myosi Under-expressed 48 Molecular G43124,CG43 n AEL 1726 function hydrolase activity GO:0016787 3.00E-05 1.39 246 1292 196.93 19.0% 14.3% 125,CG4678,C 10A,Nardilysin,Peptido Alpha 3 glucosyltransferase,bet Alg10,beta4G a-4- alT7,CG10166 galactosyltransferase ,CG10178,CG 7,Catalytic subunit 3A 11149,CG118 of the 51,CG30438,C oligosaccharyltransfera G33303,CG33 se complex,Catalytic 774,CG33977, subunit 3B of the CG34452,CG4 oligosaccharyltransfera 302,CG5724,C se complex,Defender G6475,CG870 against apoptotic cell 8,Dad1,GalNA death 1,GalNAc-T1,O- c-T1,GalNAc- fucosyltransferase T2,O- 1,Oligosaccharide fut1,Ost48,Os transferase Delta tDelta,Ostga subunit,Oligosaccharid mma,pgant3, e transferase gamma pgant5,pgant subunit,Oligosaccharylt 6,PIG-B,PIG- ransferase 48kD C,rt,rumi,Stt3 subunit,Phosphatidylino A,Stt3B,tw,U sitol glycan anchor gt,Ugt35b,Ug biosynthesis class transferase activity, t37b1,Ugt37c B,Phosphatidylinositol Under-expressed 48 Molecular transferring hexosyl 1,Ugt86Dd,Ug glycan anchor AEL 1726 function groups GO:0016758 4.60E-05 2.27 39 132 20.88 29.5% 2.3% t86De,wol biosynthesis class Adh-related,Alcohol dehydrogenase,Formal dehyde dehydrogenase,GDP-4- keto-6-deoxy-D- mannose 3,5- epimerase/4- reductase,Glycerol 3 phosphate dehydrogenase,Isocitra te dehydrogenase,Mitoch ondrial trifunctional protein alpha Adh,Adhr,CG1 subunit,peroxisomal 0131,CG1063 Multifunctional enzyme 8,CG1236,CG type 12766,CG188 2,Phosphogluconate 14,CG2767,C dehydrogenase,scully,S oxidoreductase G6287,CG732 epiapterin activity, acting on the 2,Fdh,Gmer,G reductase,uncharacteri CH-OH group of pdh,Idh,Mfe2, zed Under-expressed 48 Molecular donors, NAD or NADP Mtpalpha,Pgd protein,Zwischenferme AEL 1726 function as acceptor GO:0016616 6.40E-05 3.36 20 52 8.22 38.5% 1.2% ,scu,Sptr,Zw nt Acox57D- acyl-Coenzyme A d,Adh,Adhr,AI oxidase at 57D F,AOX2,Arc42 distal,Adh- ,CG10131,CG related,Alcohol 10211,CG106 dehydrogenase,Aldehyd 38,CG10672,C e oxidase 2,Apoptosis G11162,CG12 inducing 262,CG1236,C factor,Arc42,Coproporp G12766,CG14 hyrinogen oxidase,Curly 997,CG15343, Su,Cyp28d2,Cyp301a1,C CG15531,CG1 yp304a1,Cyp305a1,Cyp 8547,CG1998, 310a1,Cyp318a1,Cyp49 CG2767,CG30 a1,Cyp4ad1,Cyp4d14,Cy 427,CG31075, p6a18,Cyp6a21,Cyp6g1, CG31371,CG3 Cyp6t1,Cyp9f2,Cytochro 1559,CG3270, me P450- CG4020,CG42 4d1,Cytochrome P450- 331,CG45065, 4e1,Cytochrome P450- CG4860,CG50 4e2,Cytochrome P450- 65,CG5167,C 6a2,Cytochrome P450- G5321,CG594 6a8,Dihydropteridine 8,CG6287,CG reductase,Ecdysone 7322,CG7460, oxidase,Fatty acid CG7484,CG75 synthase Under-expressed 48 Molecular oxidoreductase 60,CG7840,C 3,Formaldehyde AEL 1726 function activity GO:0016491 8.00E-05 1.58 106 475 75.13 22.3% 6.1% G8303,CG830 dehydrogenase,GDP-4- Calnexin 99A,Calreticulin,Chaper onin containing TCP1 subunit 1,Chaperonin containing TCP1 subunit 2,Chaperonin containing TCP1 subunit 3,Chaperonin containing TCP1 subunit 5,Chaperonin containing TCP1 subunit 7,Chaperonin containing TCP1 Calr,CCT1,CCT subunit 8,Cyclophilin 2,CCT3,CCT5,C 1,Glycoprotein 93,Heat CT7,CCT8,CG1 shock 70-kDa protein 1267,CG1726 cognate 3,Heat shock 6,CG2852,Cnx gene 67Ba,Heat shock 99A,Cyp1,Gp9 protein 68,Heat-shock- 3,Hsc70- protein-70Ba,lethal (2) 3,Hsp67Ba,Hs essential for p68,Hsp70Ba, life,nudC,P58IPK,Prefol l(2)efl,nudC,P din 1,Prefoldin 58IPK,Pfdn1,P 5,Prefoldin 6,septin Under-expressed 48 Molecular unfolded protein fdn5,Pfdn6,sh interacting protein AEL 1726 function binding GO:0051082 0.00012 2.64 26 79 12.49 32.9% 1.5% v,sip3,Ugt 3,shriveled,UDP- CG30427,CG4 Fatty acyl-CoA fatty-acyl-CoA 020,CG5065,C reductase in Under-expressed 48 Molecular reductase (alcohol- G8303,CG830 oenocytes,uncharacteri AEL 1726 function forming) activity GO:0080019 0.00045 9.36 7 11 1.74 63.6% 0.4% 6,FarO,wat zed protein,waterproof Ance,Ance- Ance-2,Angiotensin 2,Art8,aurB,C converting alpC,Cdk1,Cdk enzyme,Arginine 4,CG10602,C methyltransferase G11911,CG11 8,aurora B,Calpain 912,CG12256, C,Cyclin E,Cyclin- CG1304,CG13 dependent kinase 744,CG15253, 1,Cyclin-dependent CG15254,CG1 kinase 4,Cyclophilin 5255,CG1548 1,Derlin- 5,CG17134,C 1,dodo,ERp60,GalNAc- G17266,CG17 T1,gammaTrypsin,Jona 337,CG17571, h 25Bi,Jonah CG17633,CG2 25Bii,Jonah 915,CG30025, 25Biii,Jonah CG30031,CG3 44E,lambdaTry,lesswri 0371,CG3038 ght,lethal (2) 2,CG31267,C k05911,Nardilysin,Noto G31269,CG31 pleural,O- 780,CG31954, fucosyltransferase CG32376,CG3 1,Phosphatidylinositol 2379,CG3345 glycan anchor 9,CG3355,CG biosynthesis class 3964,CG4017, U,polypeptide GalNAc Under-expressed 48 Molecular catalytic activity, CG42264,CG4 transferase AEL 1726 function acting on a protein GO:0140096 0.00083 1.31 213 1114 176.2 19.1% 12.3% 3124,CG4312 3,polypeptide GalNAc Alg10,CaBP1, Alpha 3 CG10166,CG1 glucosyltransferase,cal 0470,CG1116 cium-binding protein 2,CG11999,C 1,Canopy G13284,CG13 b,CHOp24,Defender 71,CG15168,C against apoptotic cell G17593,CG19 death 1,Derlin-1,ER 98,CG2023,C Membrane protein G2046,CG225 Complex 1,ER 4,CG2781,CG Membrane protein 2852,CG2918, Complex CG30008,CG3 3,ERp60,FK506-binding 2069,CG3227 protein 14,Golgi pH 6,CG32576,C Regulator,Grasp65,Hea G33129,CG33 t shock 70-kDa protein 303,CG33774, cognate CG33977,CG4 3,heixuedian,jagunal,K 293,CG4302,C DEL receptor,Lamin B G44252,CG48 receptor,lethal (1) 80,CG4972,C G0320,lethal (2) G6230,CG674 neighbor of 6,CG7011,CG tid,logjam,membrin,Mi 7149,CG7484, crosomal triacylglycerol CG7840,CG78 transfer protein,O- Under-expressed 48 Cellular endoplasmic 72,CG8331,C fucosyltransferase AEL 1726 component reticulum GO:0005783 2.20E-25 3.44 139 382 58.56 36.4% 8.1% G9175,CG966 1,Oligosaccharide Ccp84Aa,Ccp8 Ccp84Aa,Ccp84Ab,Ccp8 4Ab,Ccp84Ac, 4Ac,Ccp84Ad,Ccp84Af,C Ccp84Ad,Ccp8 uticular protein 4Af,CG17211, 12A,Cuticular protein CG30203,CG3 23B,Cuticular protein 1268,CG3446 30F,Cuticular protein 1,CG34462,C 35B,Cuticular protein G43333,Cpr12 47Eb,Cuticular protein A,Cpr23B,Cpr 47Ec,Cuticular protein 30F,Cpr35B,C 47Ed,Cuticular protein pr47Eb,Cpr47 49Ac,Cuticular protein Ec,Cpr47Ed,Cp 49Ad,Cuticular protein r49Ac,Cpr49A 49Ag,Cuticular protein d,Cpr49Ag,Cpr 49Ah,Cuticular protein 49Ah,Cpr51A, 51A,Cuticular protein Cpr5C,Cpr60D, 5C,Cuticular protein Cpr64Ab,Cpr6 60D,Cuticular protein 4Ad,Cpr65Ea, 64Ab,Cuticular protein Cpr65Eb,Cpr6 64Ad,Cuticular protein 5Ec,Cpr66Cb,C 65Ea,Cuticular protein pr66D,Cpr67F 65Eb,Cuticular protein a2,Cpr67Fb,C 65Ec,Cuticular protein pr78Cb,dpy,La 66Cb,Cuticular protein nA,LanB1,Lcp 66D,Cuticular protein Under-expressed 48 Cellular 2,Lcp4,Lcp65A 67Fa2,Cuticular protein AEL 1726 component extracellular matrix GO:0031012 3.60E-20 4.86 73 160 24.53 45.6% 4.2% b1,Lcp65Ad,Lc 67Fb,Cuticular protein Ance,Ance- Ance-2,Ance- 2,Ance- 5,Angiotensin 5,CG12256,C converting G13748,CG13 enzyme,Chitinase 806,CG15225, 10,Chitinase CG17211,CG1 9,crinkled,Cuticular 7337,CG1763 protein 12A,Cuticular 3,CG17974,C protein 23B,Cuticular G2852,CG291 protein 30F,Cuticular 5,CG2918,CG protein 35B,Cuticular 30197,CG302 protein 47Eb,Cuticular 03,CG31268,C protein 47Ec,Cuticular G31997,CG32 protein 47Ed,Cuticular 284,CG32379, protein 49Ac,Cuticular CG33459,CG3 protein 49Ad,Cuticular 355,CG4017,C protein 49Ag,Cuticular G42264,CG42 protein 49Ah,Cuticular 326,CG43333, protein 51A,Cuticular CG43366,CG4 protein 5C,Cuticular 386,CG4678,C protein G4847,CG517 60D,dumpy,FK506- 7,CG5397,CG binding protein 14,four- 6337,CG6347, jointed,GIP-like,Glial CG6426,CG70 Lazarillo,Heat shock 70- Under-expressed 48 Cellular 25,CG8160,C kDa protein cognate AEL 1726 component extracellular region GO:0005576 7.20E-18 2.2 208 783 120.03 26.6% 12.1% G8213,CG846 3,LanB1,Larval cuticle non- stop,pomp,Proteasome CG30382,not, alpha2 Pomp,Prosalp subunit,Proteasome ha2,Prosalpha alpha3 3,Prosalpha4, subunit,Proteasome Prosalpha5,Pr alpha4 osalpha6,Pros subunit,Proteasome alpha7,Prosbe alpha5 ta1,Prosbeta2 subunit,Proteasome ,Prosbeta3,Pr alpha6 osbeta4,Prosb subunit,Proteasome eta5,Prosbeta alpha7 6,Prosbeta7,R subunit,Proteasome pn1,Rpn10,Rp beta1 n11,Rpn12,Rp subunit,Proteasome n2,Rpn3,Rpn5 beta2 ,Rpn7,Rpn8,R subunit,Proteasome pn9,Rpt1,Rpt beta3 2,Rpt3,Rpt3R, subunit,Proteasome Rpt4,Rpt5,Rpt beta4 6,Sem1,Spase subunit,Proteasome 12,Spase22- beta5 23,Spase25,T subunit,Proteasome Under-expressed 48 Cellular ER94,twr,Uch- beta6 AEL 1726 component peptidase complex GO:1905368 8.40E-13 6.2 36 69 10.55 52.2% 2.1% L5 subunit,Proteasome Regulatory particle non- ATPase 1,Regulatory particle non-ATPase 10,Regulatory particle non-ATPase 11,Regulatory particle non-ATPase 12,Regulatory particle non-ATPase 2,Regulatory particle non-ATPase 3,Regulatory particle non-ATPase 5,Regulatory particle non-ATPase 7,Regulatory particle non-ATPase Rpn1,Rpn10,R 8,Regulatory particle pn11,Rpn12,R non-ATPase pn2,Rpn3,Rpn 9,Regulatory particle 5,Rpn7,Rpn8, triple-A ATPase Rpn9,Rpt1,Rp 1,Regulatory particle t2,Rpt3,Rpt3R triple-A ATPase ,Rpt4,Rpt5,Rp 2,Regulatory particle Under-expressed 48 Cellular proteasome accessory t6,Sem1,Uch- triple-A ATPase AEL 1726 component complex GO:0022624 2.10E-11 17.75 19 25 3.83 76.0% 1.1% L5 3,Regulatory particle Alg10,alt,Arf7 ADP ribosylation factor 9F,ArfGAP1,A at 79F,ADP ribosylation rl1,beta'COP, factor-like 1,ADP- CG10166,CG1 ribosylation factor 0470,CG1116 GTPase activating 2,CG11999,C protein 1,Alpha 3 G1371,CG145 glucosyltransferase,alu 11,CG15168,C minum tubes,Catalytic G15531,CG16 subunit 3B of the 904,CG1998,C oligosaccharyltransfera G2781,CG300 se complex,Coat 08,CG32069,C Protein (coatomer) G33052,CG33 beta',Coat Protein 303,CG33774, (coatomer) CG33977,CG3 gamma,csat,Defender 678,CG4293,C against apoptotic cell G4972,CG548 death 1,Derlin-1,ER 4,CG5510,CG Membrane protein 6230,CG6660, Complex 1,ER CG7011,CG71 Membrane protein 49,CG7872,C Complex G8708,CG917 3,ergic53,GalNAc- 5,CG9662,CG T1,Golgi complex- 9669,CG9747, localized glycoprotein Under-expressed 48 Cellular organelle Csat,Dad1,Der-1,Golgi pH AEL 1726 component subcompartment GO:0031984 1.10E-09 2.3 88 308 47.22 28.6% 5.1% 1,EMC1,EMC3 Regulator,Grasp65,GTP-

bai,CG32069, CG4293,CG54 84,CG5510,C baiser,CHOp24,eclair,er G7011,CHOp2 gic53,logjam,membrin, 4,eca,ergic53, p115,p24-related-1,p24- loj,Membrin,p related-2,Secretory 115,p24- 13,Secretory 1,p24- 22,Secretory 2,Sec13,Sec2 23,Secretory Under-expressed 48 Cellular COPII-coated ER to 2,Sec23,Sec2 24CD,uncharacterized AEL 1726 component Golgi transport vesicle GO:0030134 2.30E-09 11.2 18 27 4.14 66.7% 1.0% 4CD protein pomp,Proteasome alpha2 subunit,Proteasome alpha3 subunit,Proteasome CG30382,Pom alpha4 p,Prosalpha2, subunit,Proteasome Prosalpha3,Pr alpha5 osalpha4,Pros subunit,Proteasome alpha5,Prosal alpha6 pha6,Prosalph subunit,Proteasome a7,Prosbeta1, alpha7 Prosbeta2,Pro subunit,Proteasome sbeta3,Prosbe beta1 ta4,Prosbeta5 subunit,Proteasome ,Prosbeta6,Pr beta2 osbeta7,Rpn1 subunit,Proteasome ,Rpn10,Rpn11 beta3 ,Rpn12,Rpn2, subunit,Proteasome Rpn3,Rpn5,Rp beta4 n7,Rpn8,Rpn9 subunit,Proteasome ,Rpt1,Rpt2,Rp beta5 t3,Rpt3R,Rpt4 subunit,Proteasome ,Rpt5,Rpt6,Se beta6 Under-expressed 48 Cellular m1,TER94,Uc subunit,Proteasome AEL 1726 component proteasome complex GO:0000502 5.90E-09 12.97 16 23 3.48 69.6% 0.9% h-L5 beta7 26-29-p,Adgf- 26-29kD- C,Alp4,Ance,A proteinase,Adenosine nce-2,Ance- deaminase-related 5,apolpp,beta growth factor Glu,Calr,Ccp8 C,Alkaline phosphatase 4Ad,CG10264, 4,Ance-2,Ance- CG11836,CG1 5,Angiotensin 1854,CG1225 converting 6,CG13748,C enzyme,apolipophorin, G14820,CG15 beta 225,CG15497, glucuronidase,Calreticu CG17271,CG1 lin,Ccp84Ad,Chitinase 7633,CG1791 5,Chitinase 9,Cuticular 9,CG17974,C protein 51A,Cuticular G2016,CG285 protein 2,CG2915,CG 67Fb,easter,Esterase 2918,CG3126 6,FK506-binding 6,CG31268,C protein 14,four- G31997,CG32 jointed,Glial 379,CG33459, Lazarillo,Glycoprotein CG3355,CG34 93,Heat shock 70-kDa 034,CG3868,C protein cognate G4017,CG422 3,Insulin-like peptide 64,CG42326,C 2,lethal (2) Under-expressed 48 Cellular G43333,CG43 k05911,Lysozyme AEL 1726 component extracellular space GO:0005615 1.00E-08 2.01 107 415 63.62 25.8% 6.2% 366,CG4386,C D,Lysozyme P,Lysozyme

Catalytic subunit 3B of the oligosaccharyltransfera se complex,Defender against apoptotic cell death 1,Oligosaccharide transferase Delta CG33303,CG3 subunit,Oligosaccharid 3774,CG9662, e transferase gamma CG9669,Dad1, subunit,Oligosaccharylt Ost48,OstDelt ransferase 48kD Under-expressed 48 Cellular oligosaccharyltransfer a,Ostgamma, subunit,uncharacterize AEL 1726 component ase complex GO:0008250 4.60E-08 Inf 9 9 1.38 100.0% 0.5% Stt3B d protein Alg10,alt,CG1 Alpha 3 0166,CG1047 glucosyltransferase,alu 0,CG11162,C minum tubes,Catalytic G11999,CG13 subunit 3B of the 71,CG14511,C oligosaccharyltransfera G15168,CG15 se complex,Defender 531,CG16904, against apoptotic cell CG1998,CG27 death 1,Derlin-1,ER 81,CG30008,C Membrane protein G32069,CG33 Complex 1,ER 303,CG33774, Membrane protein CG33977,CG3 Complex 3,ergic53,GTP- 678,CG4293,C binding G4972,CG548 protein,jagunal,Lamin 4,CG5510,CG B receptor,lethal (1) 6230,CG6660, G0320,lethal (2) CG7011,CG71 neighbor of tid,medial 49,CG7872,C glomeruli,membrin,Oli G9175,CG966 gosaccharide 2,CG9669,CG transferase Delta 9747,Dad1,De subunit,Oligosaccharid r- e transferase gamma 1,EMC1,EMC3 subunit,Oligosaccharylt ,ergic53,Gtp- ransferase 48kD Under-expressed 48 Cellular endoplasmic bp,jagn,l(1)G subunit,PAPS AEL 1726 component reticulum membrane GO:0005789 8.50E-08 2.69 50 157 23.77 31.8% 2.9% 0320,l(2)not,L transporter baiser,CHOp24,Coat Protein (coatomer) alpha,Coat Protein alphaCOP,bai, (coatomer) CG5484,CG55 gamma,eclair,ergic53,l 10,CHOp24,ec ogjam,p24-related- endoplasmic a,ergic53,ga 1,p24-related- reticulum-Golgi mmaCOP,loj, 2,Secretory Under-expressed 48 Cellular intermediate p24-1,p24- 22,uncharacterized AEL 1726 component compartment GO:0005793 4.70E-07 13.38 12 17 2.61 70.6% 0.7% 2,Sec22 protein Regulatory particle non- ATPase 1,Regulatory particle non-ATPase 10,Regulatory particle non-ATPase 2,Regulatory particle triple-A ATPase 1,Regulatory particle triple-A ATPase 2,Regulatory particle triple-A ATPase 3,Regulatory particle triple-A ATPase 3- related,Regulatory Rpn1,Rpn10,R particle triple-A ATPase pn2,Rpt1,Rpt 4,Regulatory particle proteasome 2,Rpt3,Rpt3R, triple-A ATPase Under-expressed 48 Cellular regulatory particle, Rpt4,Rpt5,Rpt 5,Regulatory particle AEL 1726 component base subcomplex GO:0008540 1.30E-06 18.55 10 13 1.99 76.9% 0.6% 6 triple-A ATPase 6

disc proliferation abnormal,Minichromos ome maintenance 2,Minichromosome maintenance 3,Minichromosome maintenance 5,Minichromosome maintenance CG3430,dpa, 6,Minichromosome Mcm2,Mcm3, maintenance Under-expressed 48 Cellular Mcm5,Mcm6, 7,uncharacterized AEL 1726 component MCM complex GO:0042555 2.00E-06 Inf 7 7 1.07 100.0% 0.4% Mcm7 protein aluminum tubes,Defender against apoptotic cell death 1,ER Membrane protein Complex 1,ER Membrane protein Complex 3,Lamin B receptor,lethal (2) neighbor of tid,medial glomeruli,PAPS alt,CG10470,C transporter G14511,CG15 2,Phosphatidylinositol 168,CG16904, glycan anchor CG2781,CG30 biosynthesis class 008,CG3678,C G,Phosphatidylinositol G4293,CG666 glycan anchor 0,CG7011,CG biosynthesis class 9175,Dad1,E U,prenyl protease type MC1,EMC3,l(2 I,Secretory 63,Signal )not,LBR,mei peptide go,Papst2,PIG- peptidase,Spase 12- G,PIG- subunit,Translocation integral component of U,Sec63,Spas protein Under-expressed 48 Cellular endoplasmic e12,Spp,ste24 1,uncharacterized AEL 1726 component reticulum membrane GO:0030176 2.40E-06 3.56 26 67 10.27 38.8% 1.5% a,Trp1 protein

Regulatory particle non- ATPase 11,Regulatory particle non-ATPase 12,Regulatory particle non-ATPase 3,Regulatory particle non-ATPase 5,Regulatory particle non-ATPase 7,Regulatory particle non-ATPase Rpn11,Rpn12, 8,Regulatory particle proteasome Rpn3,Rpn5,Rp non-ATPase Under-expressed 48 Cellular regulatory particle, lid n7,Rpn8,Rpn9 9,Suppressor of exocyst AEL 1726 component subcomplex GO:0008541 1.00E-05 22.23 8 10 1.53 80.0% 0.5% ,Sem1 mutations 1 Proteasome beta1 subunit,Proteasome beta2 subunit,Proteasome beta3 subunit,Proteasome Prosbeta1,Pro beta5 sbeta2,Prosbe subunit,Proteasome proteasome core ta3,Prosbeta5 beta6 Under-expressed 48 Cellular complex, beta-subunit ,Prosbeta6,Pr subunit,Proteasome AEL 1726 component complex GO:0019774 1.30E-05 Inf 6 6 0.92 100.0% 0.3% osbeta7 beta7 subunit

Signal recognition particle protein 14,Signal recognition particle protein 19,Signal recognition particle protein 54k,Signal recognition particle protein 68,Signal recognition particle protein Srp14,Srp19,S 72,Signal recognition signal recognition rp54k,Srp68,S particle protein Under-expressed 48 Cellular particle, endoplasmic rp72,Srp9,SsR 9,Signal sequence AEL 1726 component reticulum targeting GO:0005786 1.40E-05 38.88 7 8 1.23 87.5% 0.4% beta receptor beta

Proteasome alpha2 subunit,Proteasome alpha3 subunit,Proteasome alpha4 subunit,Proteasome alpha5 CG30382,Pros subunit,Proteasome alpha2,Prosal alpha6 pha3,Prosalph subunit,Proteasome proteasome core a4,Prosalpha5 alpha7 Under-expressed 48 Cellular complex, alpha- ,Prosalpha6,P subunit,uncharacterize AEL 1726 component subunit complex GO:0019773 1.40E-05 38.88 7 8 1.23 87.5% 0.4% rosalpha7 d protein CG10418,CG2 021,CG6610,C Like Sm 3,Like Sm Under-expressed 48 Cellular G9344,LSm3, 7,uncharacterized AEL 1726 component U6 snRNP GO:0005688 7.80E-05 33.3 6 7 1.07 85.7% 0.3% LSm7 protein

Regulatory particle non- ATPase 1,Regulatory particle non-ATPase 2,Regulatory particle triple-A ATPase 3,Regulatory particle triple-A ATPase 3- related,Regulatory Rpn1,Rpn2,Rp particle triple-A ATPase Under-expressed 48 Cellular cytosolic proteasome t3,Rpt3R,Rpt4 4,Regulatory particle AEL 1726 component complex GO:0031597 7.80E-05 33.3 6 7 1.07 85.7% 0.3% ,Rpt6 triple-A ATPase 6

cid,His2A:CG3 3808,His2B:C G33872,His2B centromere Under-expressed 48 Cellular :CG33874,His identifier,histone AEL 1726 component nuclear nucleosome GO:0000788 8.40E-05 Inf 5 5 0.77 100.0% 0.3% 2B:CG33876 H2A,histone H2B

Clathrin light chain,Coat Protein (coatomer) alpha,Coat Protein (coatomer) beta,Coat Protein (coatomer) beta',Coat alphaCOP,bet Protein (coatomer) a'COP,betaCO delta,Coat Protein P,Clc,deltaCO (coatomer) P,epsilonCOP, epsilon,Coat Protein gammaCOP, (coatomer) Membrin,p11 gamma,membrin,p115, 5,Sec13,Sec2 Secretory 13,Secretory Under-expressed 48 Cellular Golgi-associated 2,Sec23,Sec2 22,Secretory AEL 1726 component vesicle membrane GO:0030660 9.50E-05 4.83 13 28 4.29 46.4% 0.8% 4CD 23,Secretory 24CD CDC45L,cid,D1 CDC45L,centromere ,DNApol- identifier,D1 alpha180,DN chromosomal Apol- protein,DNA alpha50,DNA polymerase alpha pol- 180kD,DNA polymerase alpha60,DNA alpha 50kD,DNA pol- polymerase alpha alpha73,His2 60kD,DNA polymerase A:CG33808,Hi alpha 73kD,histone s2Av,His2B:C H2A,Histone H2A G33872,His2B variant,histone :CG33874,His H2B,Origin recognition 2B:CG33876, complex subunit Under-expressed 48 Cellular Orc3,Psf1,RP 3,Psf1,Replication AEL 1726 component protein-DNA complex GO:0032993 0.00013 3.98 15 36 5.52 41.7% 0.9% A2 protein A2

Chaperonin containing TCP1 subunit 1,Chaperonin containing TCP1 subunit 2,Chaperonin containing TCP1 subunit 3,Chaperonin containing TCP1 subunit 5,Chaperonin containing TCP1 CCT1,CCT2,CC subunit 7,Chaperonin Under-expressed 48 Cellular chaperonin-containing T3,CCT5,CCT7, containing TCP1 AEL 1726 component T-complex GO:0005832 0.00027 16.65 6 8 1.23 75.0% 0.3% CCT8 subunit 8 Origin recognition complex subunit 1,Origin recognition complex subunit 2,Origin recognition complex subunit 3,Origin recognition nuclear origin of complex subunit Under-expressed 48 Cellular replication recognition Orc1,Orc2,Orc 5,Origin recognition AEL 1726 component complex GO:0005664 0.00044 27.73 5 6 0.92 83.3% 0.3% 3,Orc5,Orc6 complex subunit 6 Der-1,Gtp- Derlin-1,GTP-binding bp,Sec61alph protein,Sec61 alpha Under-expressed 48 Cellular rough endoplasmic a,Sec61beta,S subunit,Sec61 beta AEL 1726 component reticulum membrane GO:0030867 0.00044 27.73 5 6 0.92 83.3% 0.3% ec63 subunit,Secretory 63

CDC45L,Chromosome CDC45L,CG10 transmission fidelity 336,Ctf4,DNA 4,DNA polymerase pol- alpha 180kD,DNA alpha180,DN polymerase alpha Apol- 50kD,DNA polymerase alpha50,DNA alpha 60kD,DNA pol- polymerase alpha alpha60,DNA 73kD,Minichromosome pol- maintenance alpha73,Mcm 10,Replication protein Under-expressed 48 Cellular nuclear replication 10,RPA2,time A2,timeout,uncharacter AEL 1726 component fork GO:0043596 0.00048 5.05 10 21 3.22 47.6% 0.6% out ized protein DNApol- alpha180,DN DNA polymerase alpha Apol- 180kD,DNA polymerase alpha50,DNA alpha 50kD,DNA alpha DNA pol- polymerase alpha Under-expressed 48 Cellular polymerase:primase alpha60,DNA 60kD,DNA polymerase AEL 1726 component complex GO:0005658 0.00055 Inf 4 4 0.61 100.0% 0.2% pol-alpha73 alpha 73kD

Spase12,Spas Spase 12-subunit,Spase e22- 22/23-subunit,Spase 25- Under-expressed 48 Cellular signal peptidase 23,Spase25,t subunit,twisted bristles AEL 1726 component complex GO:0005787 0.00055 Inf 4 4 0.61 100.0% 0.2% wr roughened eye hoi-polloi,Like Sm 3,Like Sm 7,PHD finger protein 5a,pre-mRNA processing factor 8,Small nuclear ribonucleoprotein G,Small ribonucleoprotein particle protein SmB,Small ribonucleoprotein particle protein SmD1,Small ribonucleoprotein particle protein CG10418,CG2 SmD2,Small 021,CG3542,C ribonucleoprotein G4849,CG661 particle protein 0,CG9344,hoi SmE,Small p,LSm3,LSm7, ribonucleoprotein Phf5a,Prp8,Sf particle protein 3b6,SmB,Sm SmF,Splicing factor 3b small nuclear D1,SmD2,Sm subunit Under-expressed 48 Cellular ribonucleoprotein E,SmF,SNRPG 6,U2A,uncharacterized AEL 1726 component complex GO:0030532 7.00E-04 2.72 19 58 8.89 32.8% 1.1% ,U2A protein Coat Protein (coatomer) alpha,Coat Protein (coatomer) beta,Coat Protein (coatomer) beta',Coat alphaCOP,bet Protein (coatomer) a'COP,betaCO delta,Coat Protein P,deltaCOP,ep (coatomer) Under-expressed 48 Cellular silonCOP,gam epsilon,Coat Protein AEL 1726 component COPI vesicle coat GO:0030126 0.00071 11.1 6 9 1.38 66.7% 0.3% maCOP (coatomer) gamma Coat Protein (coatomer) alpha,Coat Protein (coatomer) beta,Coat Protein (coatomer) beta',Coat alphaCOP,bet Protein (coatomer) a'COP,betaCO delta,Coat Protein P,deltaCOP,ep (coatomer) Under-expressed 48 Cellular silonCOP,gam epsilon,Coat Protein AEL 1726 component COPI-coated vesicle GO:0030137 0.00071 11.1 6 9 1.38 66.7% 0.3% maCOP (coatomer) gamma Nucleoporin 107kD,Nucleoporin Nup107,Nup1 133kD,Nucleoporin 33,Nup37,Nu 37kD,Nucleoporin Under-expressed 48 Cellular nuclear pore outer p43,Nup75,Se 43kD,Nucleoporin AEL 1726 component ring GO:0031080 0.00071 11.1 6 9 1.38 66.7% 0.3% c13 75kD,Secretory 13

hoi-polloi,Like Sm 3,Small ribonucleoprotein particle protein SmB,Small ribonucleoprotein particle protein CG10418,CG2 SmD2,Small 021,CG6610,C ribonucleoprotein G9344,hoip,L particle protein Under-expressed 48 Cellular U4/U6 x U5 tri-snRNP Sm3,SmB,Sm SmE,uncharacterized AEL 1726 component complex GO:0046540 0.00098 5 9 19 2.91 47.4% 0.5% D2,SmE protein