CLUSTAL O(1.1.0) Multiple Sequence Alignment
Supplemental Figure 1
CLUSTAL O(1.1.0) multiple sequence alignment
human_PepT1|AAB61693.1 ------
chimpanzee_PepT1|XP_522705.3 ------
Rhesus_monkey_PepT1|NP_001028071.1 ------
crab-eating_macaque_PepT1|AAQ56235.1 ------
house_mouse_PepT1|NP_444309.2 ------
Norway_rat_PepT1|BAA09318.1 ------
dog_PepT1|NP_001003036.1 ------
horse_PepT1|XP_001493109.3 ------MERAQHVTDADKYRHCVHVGSSERTPDK-G------RGQLVSRFRGDRRA
pig_PepT1|AAO43094.1 ------
cattle_PepT1|NP_001092848.1 ------
sheep_PepT1|AAK14788.1 ------
rabbit_PepT1|AAA17721.1 ------
gray_short-tailed_opossum_PepT1|XP_001377037.2 MGAGLATLNGSASLGDVR------LWPSPRSEEKAGRNFAQLFFAKGMILQDFFYD---
platypus_PepT1|XP_001506250.2 ------
chicken_PepT1|AAK39954.1 ------
turkey_PepT1|AAO16604.1 ------
western_clawed_frog_PepT1|XP_002935692.1 ------
three-spined_stickleback_PepT1a| ------
China_rockfish_PepT1a|ABV82968.1 ------
Nile_tilapia_PepT1a| ------
Japanese_medaka_PepT1a| ------
mummichog_PepT1a|AEX92274.1 ------
southern_platyfish_PepT1a| ------
torafugu_PepT1a| ------
Atlantic_cod_PepT1a| ------
zebrafish_PepT1a|XP_001919914.3 ------
Japanese_eel_PepT1a|BAM67012.1 ------
common_carp_PepT1b|AEX13747.1 ------
red_crucian_carp_PepT1b|AFI42054.1 ------
red_crucian_x_common_carp_PepT1b|AFI42056.1 ------
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 ------
grass_carp_PepT1b|AET36827.1 ------
zebrafish_PepT1b|AAQ65244.1 ------
Atlantic_cod_PepT1b|AAY17354.1 ------
Atlantic_salmon_PepT1b|BAH24102.1 ------
southern_platyfish_PepT1b| ------
mummichog_PepT1b|AEX92273.1 ------
spotted_green_pufferfish_PepT1b| ------
torafugu_PepT1b| ------
Japanese_medaka_PepT1b| ------
Antarctic_icefish_PepT1b|AAO39705.2 ------
three-spined_stickleback_PepT1b| ------
European_seabass_PepT1b|ACI49693.2 ------
white_grouper_PepT1b|AFP33141.1 ------
yellow_perch_PepT1b|ACX49753.2 ------
human_PepT1|AAB61693.1 ------
chimpanzee_PepT1|XP_522705.3 ------
Rhesus_monkey_PepT1|NP_001028071.1 ------
crab-eating_macaque_PepT1|AAQ56235.1 ------
house_mouse_PepT1|NP_444309.2 ------
Norway_rat_PepT1|BAA09318.1 ------
dog_PepT1|NP_001003036.1 ------
horse_PepT1|XP_001493109.3 GAAGMKGA------PE---MEKAVHR---R------GFAPTRLDSH-PFS-C---C---
pig_PepT1|AAO43094.1 ------
cattle_PepT1|NP_001092848.1 ------
sheep_PepT1|AAK14788.1 ------
rabbit_PepT1|AAA17721.1 ------
gray_short-tailed_opossum_PepT1|XP_001377037.2 -GAGIQTCLPFLPVPPSSHVSNSVKEILAAVL-----VLVGGDEEEI-HVS-C---L---
platypus_PepT1|XP_001506250.2 ------MAA---SKN-AAN-S---N---
chicken_PepT1|AAK39954.1 ------
turkey_PepT1|AAO16604.1 ------
western_clawed_frog_PepT1|XP_002935692.1 ------MDPSAPNRA-RADTC---PSTS
three-spined_stickleback_PepT1a| ------MEANRYTEFFTC---TDNE
China_rockfish_PepT1a|ABV82968.1 ------M---TDNE
Nile_tilapia_PepT1a| ------M---TDNE
Japanese_medaka_PepT1a| ------M---TDKE
mummichog_PepT1a|AEX92274.1 ------
southern_platyfish_PepT1a| ----MKH------SHSHLSGEKDK----VLSACGTNLKGARESEQQPHLNM---TEKD
torafugu_PepT1a| ------MD
Atlantic_cod_PepT1a| ----MKA------NYRDLARELSAIMHEQISPVEDGMKSVLPDSLHIFNAISGTPTGA
zebrafish_PepT1a|XP_001919914.3 ------MPDS
Japanese_eel_PepT1a|BAM67012.1 ------MT
common_carp_PepT1b|AEX13747.1 ------MA
red_crucian_carp_PepT1b|AFI42054.1 ------MAD
red_crucian_x_common_carp_PepT1b|AFI42056.1 ------MA
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 ------MAA
grass_carp_PepT1b|AET36827.1 ------M
zebrafish_PepT1b|AAQ65244.1 ------M
Atlantic_cod_PepT1b|AAY17354.1 ------ME
Atlantic_salmon_PepT1b|BAH24102.1 ------MT
southern_platyfish_PepT1b| ------MG
mummichog_PepT1b|AEX92273.1 ------
spotted_green_pufferfish_PepT1b| ------MA
torafugu_PepT1b| ------M
Japanese_medaka_PepT1b| ------MA
Antarctic_icefish_PepT1b|AAO39705.2 ------ME
three-spined_stickleback_PepT1b| ------MA
European_seabass_PepT1b|ACI49693.2 ------
white_grouper_PepT1b|AFP33141.1 ------MA
yellow_perch_PepT1b|ACX49753.2 ------MA
1
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human_PepT1|AAB61693.1 ------MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTA
chimpanzee_PepT1|XP_522705.3 ------MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTA
Rhesus_monkey_PepT1|NP_001028071.1 ------MGMSKSQGCFGYPLSIFFIVANEFCERFSYYGMRGILILYFTNFFSWDDNMSTA
crab-eating_macaque_PepT1|AAQ56235.1 ------MGMSKSQGCFGYPLSIFFIVANEFCERFSYYGMRGILILYFTNFFSWDDNMSTA
house_mouse_PepT1|NP_444309.2 ------MGMSKSRGCFGYPLSIFFIVVNEFCERFSYYGMRALLVLYFRNFLGWDDNLSTA
Norway_rat_PepT1|BAA09318.1 ------MGMSKSRGCFGYPLSIFFIVVNEFCERFSYYGMRALLVLYFRNFLGWDDDLSTA
dog_PepT1|NP_001003036.1 ------MGMSKSYGCFGYPLSIFFIVVNEFCERFSYYGMRALLILYFRRFIGWDDNLSTA
horse_PepT1|XP_001493109.3 SSNRSSDRMSRSQSCFGYPLSIFFIVVNEFCERFSYYGMRALLILYFTLFIGWDDNLSTA
pig_PepT1|AAO43094.1 ------MGMSVPQSCFGYPLSIFFIVVNEFCERFSYYGMRALLILYFRLFIGWNDNLSTA
cattle_PepT1|NP_001092848.1 ------MGMSVPKSCFGYPLSIFFIVVNEFCERFSYYGMRALLILYFQRFLGWNDNLGTA
sheep_PepT1|AAK14788.1 ------MGMSVPKSCFGYPLSIFFIVVNEFCERFSYYGMRALLILYFQRFLGWNDNLGTA
rabbit_PepT1|AAA17721.1 ------MGMSKSLSCFGYPLSIFFIVVNEFCERFSYYGMRALLILYFRNFIGWDDNLSTV
gray_short-tailed_opossum_PepT1|XP_001377037.2 -----DNGKKGTGSCLGYPISIFFIIVNEFCERFSYYGMRAILVLYFQRFLGWNDNLSTA
platypus_PepT1|XP_001506250.2 AFQWAFLGMSKSLSCFGYPVSIFFIIINEFCERFSYYGMRAVLVLYFQRFLGWNDNLSTA
chicken_PepT1|AAK39954.1 MAAKSKSKGRSVPNCFGYPLSIFFIVINEFCERFSYYGMRAVLVLYFKYFLRWDDNFSTA
turkey_PepT1|AAO16604.1 MAAKSKSKGSSVPNCFGYPLSIFFIVINEFCERFSYYGMRAVLVLYFKYFLRWDDNLSTA
western_clawed_frog_PepT1|XP_002935692.1 SALIQRRGEKKQPGCFGYPLSIFFIVINEFCERFSYYGMRAVLVLYFKYFLHWDDNLATV
three-spined_stickleback_PepT1a| DPKKQKGGKGTSKVLFGYPLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLATS
China_rockfish_PepT1a|ABV82968.1 DPKKGKDNRGTGTLVCGYPLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLATS
Nile_tilapia_PepT1a| DPKKQGKGNGKSKDVCGYPLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLQWDEDLATS
Japanese_medaka_PepT1a| DLKKEKKGKGKSKVVCGYPISIFFIVVNEFCERFSYYGMRAVLVLYFKYFLQWDDDLATS
mummichog_PepT1a|AEX92274.1 -----MNSKKRRVTGCGYPISIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLATS
southern_platyfish_PepT1a| DLKKESKGRGKCKEVFGYPISIFFIIVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLAIS
torafugu_PepT1a| EDHKKEKKRGTDKVVCGYPLSIFFIVVNEFCERFSYYGMRAVLVLYFRYFLLWGDDLATS
Atlantic_cod_PepT1a| TIQGVPCTSSVSIVICGYPLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLATS
zebrafish_PepT1a|XP_001919914.3 KMDETKKKKKKTAECCGYPISIFFIVVNEFCERFSYYGMRAVLVLYFRYFLLWDDDLATS
Japanese_eel_PepT1a|BAM67012.1 DLEKREKKKPKSKVVCGYPISIFFIVVNEFCERFSYYGMRAVLVLYFRYFLRWDDDTATS
common_carp_PepT1b|AEX13747.1 DEERNTKKAKNRPSCLGYPVSIFFIVVNEFCERFSYYGMKAVLVLYFKYFIGWDNDLSTT
red_crucian_carp_PepT1b|AFI42054.1 NEERKTKKTKNRPSCLGYPVSIFFIVVNEFCERFSYYGMKAVLVLYFKYFIGWDNDLSTT
red_crucian_x_common_carp_PepT1b|AFI42056.1 NEEKNTKKAKNRPSCLGYPVSIFFIVVNEFCERFSYYGMKAVLVLYFKYFIGWDNDLSTT
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 NEERKTKKTKNRPSCLGYPVSIFFIVVNEFCERFSYYGMKAVLVLYFKYFIGWDNDLSTT
grass_carp_PepT1b|AET36827.1 ANKEGKNAREQGPSCLGYPVSIFFIVVNEFCERFSYYGMKAVLALYFKYFIGWDNDLSTT
zebrafish_PepT1b|AAQ65244.1 ADKEGHKQKKERASCFGYPVSIFFIVVNEFCERFSYYGMKAVLVLYFKYFIGWDDDLSTT
Atlantic_cod_PepT1b|AAY17354.1 DREN-GKKPKKSVTVCGYPLSIFFIVVDEFCERFSYYGMKAVLVLYFRYFLRWDDDLAIT
Atlantic_salmon_PepT1b|BAH24102.1 DI--DVKKSKRKVDVCGYPLSIFFIVVNEFCERFSYYGMRAVLVLYFRYFLKWDDDLSTS
southern_platyfish_PepT1b| DK-EKKTGKKKSVTIFGYPLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLKWDDDFSTT
mummichog_PepT1b|AEX92273.1 -----MKSKKRSVTVCGYPLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLKWDDDFSTT
spotted_green_pufferfish_PepT1b| DK---EKKKSKSKTVLDYPISIFFIVVNEFCERFSYYGMRTVLVLYLNNFLNWDEDFATT
torafugu_PepT1b| DK---ETKKPKSKTLLGYPISIFFIVVNEFCERFSYYGMRTVLVLYLNYFLNFDDDFATT
Japanese_medaka_PepT1b| DKEEHKKPKKKSPKVCGYPISIFFIVINEFCERFSYYGMRAVLVLYFKYFLRWDDDFATT
Antarctic_icefish_PepT1b|AAO39705.2 DNDETKKPTQKTAVICGYPISIFFIVVNEFCERFSYYGMRAVLVLYFKYFLKWDDDFSTT
three-spined_stickleback_PepT1b| AKDEGKDPKKKSATVCGFPISIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDFATT
European_seabass_PepT1b|ACI49693.2 ---MADGKKSKSATACGYPISIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDFATT
white_grouper_PepT1b|AFP33141.1 DTDEMRKPKKKSATIFGFPISIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDFATT
yellow_perch_PepT1b|ACX49753.2 DK-DIKKSKKKNATVCGYPLSFFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDFATT
:*:*:***: :***********: :* **: *: : :: .
2 3
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human_PepT1|AAB61693.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGT
chimpanzee_PepT1|XP_522705.3 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVISVSSINDLTDHNHDGT
Rhesus_monkey_PepT1|NP_001028071.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVISVSSINDLTDHNHDGT
crab-eating_macaque_PepT1|AAQ56235.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVISVSSINDLTDHNHDGT
house_mouse_PepT1|NP_444309.2 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVISVSSINDLTDHDHNGS
Norway_rat_PepT1|BAA09318.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVISVSSINDLTDHDHDGS
dog_PepT1|NP_001003036.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTAVSSINDLTDYNKDGT
horse_PepT1|XP_001493109.3 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQVVLAVSSINDLTDGNRDGT
pig_PepT1|AAO43094.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQVVMAVSSINDLTDFDHNGT
cattle_PepT1|NP_001092848.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQVVIAVSSINDLTDFNHDGT
sheep_PepT1|AAK14788.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQVVIAVSSINDLTDFNHDGT
rabbit_PepT1|AAA17721.1 IYHTFVALCYLTPILGALIADAWLGKFKTIVWLSIVYTIGQAVTSLSSVNELTDNNHDGT
gray_short-tailed_opossum_PepT1|XP_001377037.2 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTLGQAVTAISSINDLSDNNHDGN
platypus_PepT1|XP_001506250.2 IYHTFIALCYLTPILGALIADSWLGKFKTIIYLSIVYTIGQAVTAISSINDLTDSDHDGT
chicken_PepT1|AAK39954.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVMAVSSINDMTDQNRDGN
turkey_PepT1|AAO16604.1 IYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVMAISSINDMTDQNRDGN
western_clawed_frog_PepT1|XP_002935692.1 IYHTFVAICYLTPILGAIIADSWLGKFKTIVYLSIVYTVGQVVMAVSAIHDLTDGNRDGT
three-spined_stickleback_PepT1a| IYHVFVALCYLTPILGAIVADSWLGKFKTIIYLSIVYAIGQVTMAVSAIHDITDTDRDGT
China_rockfish_PepT1a|ABV82968.1 IYHVFVALCYLTPILGAIVADSWLGKFKTIIYLSIVYAIGQVAMAVSAVHDITDADRDGS
Nile_tilapia_PepT1a| IYHTFVALCYLTPILGAIVADSWLGKFKTIIYLSIVYTIGQVAMAVSAVHDITDSNRDGT
Japanese_medaka_PepT1a| IYHTFVALCYLTPILGAIVADSWLGKFKTIIYLSIVYAIGQVAMAVSAIHDITDSDRDGT
mummichog_PepT1a|AEX92274.1 FYHTFVAFCYLTPILGAIVADSWLGKFKTIIYLSIVYAIGQVAMAVSAIHDITDSNRDGT
southern_platyfish_PepT1a| IYHTFVAFCYLTPILGAIIADSWLGKFNTIIYLSIVYAIGQVAMAVSAIHDITDSDRDGS
torafugu_PepT1a| IYHTFVALCYLTPILGAIVADSWLGKYKTIIYLSIVYAIGQVAMAVSAIHDITDTNHDGK
Atlantic_cod_PepT1a| IYHAFVALCYLTPILGAIVADSWLGKFKTIIYLSIVYALGQVVMAISAIHDLTDYDWNGT
zebrafish_PepT1a|XP_001919914.3 IYHAFVALCYLTPILGAIIADSWLGKFKTIIYLSIVYAVGQVVMAVSTIHDITDANRDGT
Japanese_eel_PepT1a|BAM67012.1 IYHTFVALCYLTPIMGAIVADSWLGKFKTIVYLSIVYTIGQAVLAISAIHDITDKDQDGT
common_carp_PepT1b|AEX13747.1 IYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYTIGQVIMAISAIHDITDTNRDGT
red_crucian_carp_PepT1b|AFI42054.1 IYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYTIGQVIMAISAIHDITDTDKDGT
red_crucian_x_common_carp_PepT1b|AFI42056.1 IYHTFVALCYLTPILGAMGANSWLGKFKTIVNLSIVYTIGQVIMAIRAIHDITDTNRDGT
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 IYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYTIGQVIMAISAIHDITDTNKDGT
grass_carp_PepT1b|AET36827.1 IYHTFVALCYLTPIMGAIIADSWLGKFKTIVYLSIVYTIGQVIMAVSSIHDITDFNKDGV
zebrafish_PepT1b|AAQ65244.1 IYHTFVALCYLTPIMGAIIADSWLGKFKTIVYLSIVYTIGQVIMAISAIHDITDANRDGK
Atlantic_cod_PepT1b|AAY17354.1 IYHTFVALCYLTPILGAIVADSWLGKFKTIVYLSIVYTLGQVVMAISAIHDITDANKDGT
Atlantic_salmon_PepT1b|BAH24102.1 IYHTFIALCYLTPILGAIVADSWLGKFKTIVYLSIVYTVGQVVMAVSAIHDITDTDRDGT
southern_platyfish_PepT1b| IYHTFVALCYLSPILGAIIADSWLGKFKTIVYLSIVYTAGQVIMAVGAINDITDGNKDGT
mummichog_PepT1b|AEX92273.1 IYHTFVALCYLSPILGAIVADSWLGKFKTIVYLSVVYAAGQVVMAVSAIHDITDGNKDGT
spotted_green_pufferfish_PepT1b| IYHTFVALCYLTPILGAIVADSWLGKYKTIVYLSIVYAVGQVVLAVSAIHDITDTNRDGT
torafugu_PepT1b| IYHTFVALCYLTPILGAIIADSWLGKYKTIVYLSIVYTVGQVVLAVSAIHDITDANRDGI
Japanese_medaka_PepT1b| IYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYTLGQVVLAISAIHDITDTNKDGT
Antarctic_icefish_PepT1b|AAO39705.2 IYHTFVALCYLTPILGAIVADSWLGKFKTIVYLSIVYMLGQVVMAISAIHDLTDANMDGT
three-spined_stickleback_PepT1b| IYHTFVALCYLTPIMGAIVADSWLGKFKTIVYLSIVYTVGQVVLAVSAIHDITDTNRDGT
European_seabass_PepT1b|ACI49693.2 IYHTFVALCYLTPILGAIVADSWLGKFKTIVYLSIVYTLGQIVMAISAIHDITDSNKDGI
white_grouper_PepT1b|AFP33141.1 IYHTFVALCYLTPILGAIVADSWLGKFKTIVYLSIVYALGQVVLAVSAIHDITDANKDGT
yellow_perch_PepT1b|ACX49753.2 IYHTFVALCYLTPILGAIVADSWLGKFKTIVYLSIVYTLGQVVMAISAIRDMTDGNKDGT
:**.*:*:***:**:**: *::****::**: **:** ** :: ::.:::* : :*
4 5
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human_PepT1|AAB61693.1 PDSLPVHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
chimpanzee_PepT1|XP_522705.3 PDSLPVHVVLSMIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
Rhesus_monkey_PepT1|NP_001028071.1 PDSLPAHVALSMIGLALIALGTGGIKPCVSAFGGDQFEEGQEKRRNRFFSMFYLAINAGS
crab-eating_macaque_PepT1|AAQ56235.1 PDSLPVHVALSMIGLALIALGTGGIKPCVSAFGGDQFEEGQEKRRNRFFSMFYLAINAGS
house_mouse_PepT1|NP_444309.2 PDSLPVHVALSMVGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINGGS
Norway_rat_PepT1|BAA09318.1 PNNLPLHVALSMIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
dog_PepT1|NP_001003036.1 PDNLSVHVALSMIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
horse_PepT1|XP_001493109.3 PDSLPVHVALSMIGLALIAFGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
pig_PepT1|AAO43094.1 PNSMSVHVALSMIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
cattle_PepT1|NP_001092848.1 PDSISVHVALSMIGLVLIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
sheep_PepT1|AAK14788.1 PNNISVHVALSMIGLVLIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
rabbit_PepT1|AAA17721.1 PDSLPVHVAVCMIGLLLIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGS
gray_short-tailed_opossum_PepT1|XP_001377037.2 PDNIALHVSLSMIGLALIALGTGGIKPCVSAFGGDQFEEHQEKQRNRFFSIFYLAINAGS
platypus_PepT1|XP_001506250.2 PNVMSLHVALSMIGLALIALGTGGIKPCVSAFGGDQFEESQEKQRNRFFSIFYLAINAGS
chicken_PepT1|AAK39954.1 PDNIAVHIALSMTGLILIALGTGGIKPCVSAFGGDQFEEHQEKQRSRFFSIFYLSINAGS
turkey_PepT1|AAO16604.1 PDNIAVHIALSVTGLILIALGTGGIKPCVSAFGGDQFEEHQEKQRSRFFSIFYLSINAGS
western_clawed_frog_PepT1|XP_002935692.1 PDTLEVHVALSVIGLLLIALGTGGIKPCVAAFGGDQFEENQDKQRSQFFSIFYLSINAGS
three-spined_stickleback_PepT1a| PNNMTVHVVLSMLGLLLIALGTGGIKPCVAAFGGDQFSDHQEKQRRTFFSVFYLCINGGS
China_rockfish_PepT1a|ABV82968.1 PDDMTFHVVLSMVGLFLIALGTGGIKPCVAAFGGDQFADHQEKQRRTFFSVFYLCINGGS
Nile_tilapia_PepT1a| PDNMTFHVVLSMVGLFLIALGTGGIKPCVAAFGGDQFSEHQDKQRRTFFSVFYLCINGGS
Japanese_medaka_PepT1a| PNNMTFHVVLSMVGLFLIALGTGGIKPCVAAFGGDQFDDHQEKQRRTFFSVFYLCINGGS
mummichog_PepT1a|AEX92274.1 PDNLTFHVALSMVGLLLIALGTGGIKPCVAAFGGDQFGDTQEKQRRTFFSVFYLCINGGS
southern_platyfish_PepT1a| PDNLTFHIVLSMVGLLLIALGTGGIKPCVAAFGGDQFGEHQDKQRRTFFSVFYLCINGGS
torafugu_PepT1a| PDNMTFHVVLAMVGLFLIALGTGGIKPCVAAFGGDQFTDKQEKQRSTFFSVFYLCINGGS
Atlantic_cod_PepT1a| PDNMTLHVALSMVGLVLIALGTGGIKPCVAAFGGDQFQDHQERQRSTFFSVFYLCINAGS
zebrafish_PepT1a|XP_001919914.3 PDNFTLHIALSMLGLVLIALGTGGIKPCVAAFGGDQFQEHQSRQLNTFFSVFYLCINAGS
Japanese_eel_PepT1a|BAM67012.1 PNNMTFHVALSMTGLILIALGTGGIKPCVAAFGGDQFSDEQEKQRSTFFSIFYLSINAGS
common_carp_PepT1b|AEX13747.1 PDNMTFHTAMSMLGLILIALGTGGIKPCVAAFGGDQFEEHQEKQRSTFFSIFYLSINAGS
red_crucian_carp_PepT1b|AFI42054.1 PDNMTFHTAMSMLGLILIALGTGGIKPCVAAFGGDQFEEHQEEQRSTFFSIFYLSINAGS
red_crucian_x_common_carp_PepT1b|AFI42056.1 PDNMTFHTAMSMLGLILIALGTGGIKPCVAAFGGDQFEQHQEKQRNTFFSIFYLSINAGS
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 PDNMTFHTAMSMLGLILIALGTGGIKPCVAAFGGDQFEEHQEKQRSTFFSIFYLSINAGS
grass_carp_PepT1b|AET36827.1 PDNMTLHIALSTLGLILIALGTGGIKPCVAAFGGDQFEEHQEKQRSTFFSIFYLSINAGS
zebrafish_PepT1b|AAQ65244.1 PDNKTLHISLSMLGLILIALGTGGIKPCVAAFGGDQFEDHQEKQRSTFFSIFYLSINAGS
Atlantic_cod_PepT1b|AAY17354.1 PDNMTFHVALSMVGLILIALGTGGIKPCVAAFGGDQFNEHQEKQRSTFFSIFYLSINAGS
Atlantic_salmon_PepT1b|BAH24102.1 PDNMTFHVAMSMVGLFLIALGTGGIKPCVAAFGGDQFEEHQEKQRSTFFSIFYLSINAGS
southern_platyfish_PepT1b| PDNMTFHIALSMVGLLLIALGTGGIKPCVAAFGGDQFNEDQEKQRSTFFSIFYLSINAGS
mummichog_PepT1b|AEX92273.1 PDNMALHIALSMVGLLLIALGTGGIKPCVAAFGGDQFSEDQEKQRSTFFSIFYLSINAGS
spotted_green_pufferfish_PepT1b| PDNMTFHVALSMVGLVLIALGTGGIKPCVAAFGGDQFEDHQEKQRGTFFSIFYISINAGS
torafugu_PepT1b| PDNMTFHIALSMLGLILIALGTGGIKPCVAAFGGDQFEEHQDKQRSTFFSIFYLSINAGS
Japanese_medaka_PepT1b| PDNMTFHVALSMVGLLLIALGTGGIKPCVAAFGGDQFEDHQEKQRGTFFSIFYLSINAGS
Antarctic_icefish_PepT1b|AAO39705.2 PDNMTLHVALSMVGLILIALGTGGIKPCVAAFGGDQFLDHQEKQRSTFFSIFYLSINAGS
three-spined_stickleback_PepT1b| PDNMTLHIVLSMLGLALIAVGTGGIKPCVSAFGGDQFQDHQEKQRGTFFSIFYLSINAGS
European_seabass_PepT1b|ACI49693.2 PDNMTFHVALSMVGLILIALGTGGIKPCVAAFGGDQFEDHQEKQRSTFFSIFYLSINAGS
white_grouper_PepT1b|AFP33141.1 PDNMTFHIALSMVGLILIALGTGGIKPCVAAFGGDQFDDDQEKQRSTFFSIFYLSINAGS
yellow_perch_PepT1b|ACX49753.2 PDNMSIHVALSMVGLLLIALGTGGIKPCVAAFGGDQFQDHQEKQRSTFFSIFYLSINAGS
*: * :. ** ***.*********:******* : *..: ***:**:.**.**
6
%%%%%%%%%%%%%% %%%%%%%%%%%%%%%%%%%%%%%%%
############# ###########################
human_PepT1|AAB61693.1 LLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMG
chimpanzee_PepT1|XP_522705.3 LLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMG
Rhesus_monkey_PepT1|NP_001028071.1 LLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFILGSGMYKKFQPQGNIMG
crab-eating_macaque_PepT1|AAQ56235.1 LLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFILGSGMYKKFQPQGNIMG
house_mouse_PepT1|NP_444309.2 LLSTIITPILRVQQCGIHSQQACYPLAFGVPAALMAVALIVFVLGSGMYKKFQPQGNIMG
Norway_rat_PepT1|BAA09318.1 LLSTIITPILRVQQCGIHSQQACYPLAFGVPAALMAVALIVFVLGSGMYKKFQPQGNIMG
dog_PepT1|NP_001003036.1 LISTIVTPMLRVHECGIYSQKACYPLAFGVPAALMAVSLIVFVIGSGMYKKFQPQGNVMG
horse_PepT1|XP_001493109.3 LLSTIITPILRVQQCGIHSKQACYPLAFGVPAALMAVSLIVFVIGSRMYKKFQPQGNIMA
pig_PepT1|AAO43094.1 LLSTIITPMLRVQQCGIHSTQACYPLAFGVPAALMAVSLIVFVMGSRMYKKLKPQGNVMA
cattle_PepT1|NP_001092848.1 LLSTIITPMLRVQVCGIHSKQACYPLAFGVPAALMAVSLIVFVIGSGMYKKVQPQGNIMS
sheep_PepT1|AAK14788.1 LLSTIITPMLRVQVCGIHSKQACYPLAFGVPAALMAVSLIVFVIGSGMYKKVQPQGNIMS
rabbit_PepT1|AAA17721.1 LLSTIITPMVRVQQCGIHVKQACYPLAFGIPAILMAVSLIVFIIGSGMYKKFKPQGNILS
gray_short-tailed_opossum_PepT1|XP_001377037.2 LLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVSLIVFLIGSRMYKKVQPQGNVMA
platypus_PepT1|XP_001506250.2 LLSTIITPMLRVQECGIHSKQSCYPLAFGVPAALMAIALVVFILGSGMYKKVQPQGNIMA
chicken_PepT1|AAK39954.1 LISTIITPILRAQECGIHSRQQCYPLAFGVPAALMAVSLVVFIAGSGMYKKVQPQGNIMV
turkey_PepT1|AAO16604.1 LISTVITPILRAQECGIHSRQQCYPLAFGVPAALMAVSLIVFIAGSGMYKKVQPQGNIMV
western_clawed_frog_PepT1|XP_002935692.1 LLSTIITPILRGQECGIHSQQKCYPLAFGVPAALMVVALVVFIVGSSMYKKVSPQGNIIV
three-spined_stickleback_PepT1a| LLSTIITPILRAQDCGIYSQQKCYSLAFGVPAALMLVALVVFIAGNGMYYKAEPQGNIML
China_rockfish_PepT1a|ABV82968.1 LLSTIITPILRAQECGIYTKQKCYSLAFGVPAALMVVALVVFIVGSGMYYKAEPQGNIML
Nile_tilapia_PepT1a| LLSTIITPILRGQECGIYSQQKCYSLAFGVPAALMVVALVVFIVGSGMYYKAEPEGNIML
Japanese_medaka_PepT1a| LLSTIITPILRGQTCGIYSQQKCYALAFGVPAALMVVSLVVFIVGSGMYYKAKPEGNIML
mummichog_PepT1a|AEX92274.1 LLSTIITPILRAQECGIHSKSKCYSLAFGVPAALMVVALVVFIMGSGMYYKAKPEGNIML
southern_platyfish_PepT1a| LLSTIITPILRAQNCGIHSKSKCYSLAFGVPAALMAVSLVVFIMGSGMYYKTKPEGNIML
torafugu_PepT1a| LLSTIITPILRAQECGIHTKQECYPLAFGVPAALMVVALVVFIVGSPMYYKAKPQGNIML
Atlantic_cod_PepT1a| LLSTIITPILRAQECGIHTQQKCYSLAFGVPAALMVVALVVFIAGSGMYHKAEPQGNILL
zebrafish_PepT1a|XP_001919914.3 LLSTLITPVLRAQECGIHTQQQCYPLAFGVPAALMVVSLVVFIAGSGMYTKTAPEGNIMG
Japanese_eel_PepT1a|BAM67012.1 LLSTLITPILRAQECGIHTHQKCYPLAFGVPAALMVVALVVFIVGSKMYIKAAPKGNIML
common_carp_PepT1b|AEX13747.1 LLSTLITPILRAQECGIYSKQSCFPLAFGVPAALMVVALIVFIAGHNMYIMESPKGNILL
red_crucian_carp_PepT1b|AFI42054.1 LLSTLITPILRAQECGIYSKQSCFPLAFGVPAALMVVALIVFIAGHGMYIMESPKGNILL
red_crucian_x_common_carp_PepT1b|AFI42056.1 LLSTLITPILRAQECGIYSKQSCFPLAFGVPAALMVVALIVFIAGHNMYIMESPKGNILL
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 LLSTLITPILRAQECGIYSKQSCFPLAFGVPAALMVVALIVFIAGHNMYIMESPKGNILL
grass_carp_PepT1b|AET36827.1 LLSTLITPILRSQECGIYSKQSCFPLAFGVPAALMVVALVVFIAGHSMYIMESPKGNILL
zebrafish_PepT1b|AAQ65244.1 LLSTLITPILRSQECGIYAKQSCYPLAFGVPAALMVVALIVFVIGHKMYIMESPKGNILL
Atlantic_cod_PepT1b|AAY17354.1 LLSTIITPILRAQECGIYSQQKCYPLAFGVPAALMVVALIVFIVGSRMYTKVAPKGNIML
Atlantic_salmon_PepT1b|BAH24102.1 LLSTVITPILRGQECGIHSQQKCYPLAFGVPAALMVVALIVFIMGSGMYNKTAPKGNIML
southern_platyfish_PepT1b| LLSTIITPILRAQKCGIHTQQQCYPLAFGVPAALMVVSLIVFIVGSGMYNKTAPSGNIMV
mummichog_PepT1b|AEX92273.1 LLSTVITPILRAQKCGIHTKQQCYPLAFGVPAALMVVALIVFILGSSMYNKTAPSGNIMV
spotted_green_pufferfish_PepT1b| LLSTIITPILKAQECGIYTHQQCYPLAFGVPAALMFVALVVFIVGSPMYTKTAPQGNIMV
torafugu_PepT1b| LLSTLITPILKAQECGIHTHQQCYPLAFGVPAALMFVALAVFIVGSPLYTKTAPQGNIMV
Japanese_medaka_PepT1b| LLSTIITPILRGQECGIHTQQQCYPLAFGVPAALMAVALIVFIVGSGMYHKTAPQGNIMV
Antarctic_icefish_PepT1b|AAO39705.2 LLSTVITPILRAQECGINTKQSCYPLAFGVPAALMVVALVVFILGSRMYIKTPPQGNIMV
three-spined_stickleback_PepT1b| LLSTIITPILRGQECGIYTKQKCYSLAFGVPAGLMVASLIVFIVGSGMYIKTPPQGNIMV
European_seabass_PepT1b|ACI49693.2 LLSTVITPILRAQECGIHTQQKCYPLAFGVPAALMVVALIVFIVGSGMYNKTAPQGNIIV
white_grouper_PepT1b|AFP33141.1 LLSTVITPILRAQECGIHTQQKCYPLAFGVPAALMVVALIVFIVGSGMYTKNAPQGNILV
yellow_perch_PepT1b|ACX49753.2 LLSTIITPILRAQECGIHTQQKCYSLAFGVPAALMVVALIVFIAGSGMYTKTAPQGNILV
*:**::**::: : *** . *: ****:** ** :* **: * :* *.**::
7
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######################
human_PepT1|AAB61693.1 KVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFW
chimpanzee_PepT1|XP_522705.3 KVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFW
Rhesus_monkey_PepT1|NP_001028071.1 KVAKCIHFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVMRVMFLYIPLPMFW
crab-eating_macaque_PepT1|AAQ56235.1 KVAKCIHFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVMRVMFLYIPLPMFW
house_mouse_PepT1|NP_444309.2 KVAKCIGFAIKNRFRHRSKAYPKREHWLDWAKEKYDERLISQIKMVTKVMFLYIPLPMFW
Norway_rat_PepT1|BAA09318.1 KVAKCIRFAIKNRFRHRSKAFPKRNHWLDWAKEKYDERLISQIKIMTKVMFLYIPLPMFW
dog_PepT1|NP_001003036.1 KVVKCIGFALKNRFRHRSKQFPKREHWLDWAKEKYDERLISQIKMVTKVMFLYIPLPMFW
horse_PepT1|XP_001493109.3 KVAKCIGFAITNRIRHRSNKFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFW
pig_PepT1|AAO43094.1 KVVKCIGFAIKNRFRHRSKKFPKREHWLDWAKEKYDERLICQIKMVTRVMFLYIPLPMFW
cattle_PepT1|NP_001092848.1 KVARCIGFAIKNRIRHRSKKFPKRQHWLDWASEKYDERLISQIKMVTRVMFLYIPLPMFW
sheep_PepT1|AAK14788.1 KVARCIGFAIKNRISHRSKKFPKREHWLDWASEKYDERLISQIKMVTRVMFLYIPLPMFW
rabbit_PepT1|AAA17721.1 KVVKCICFAIKNRFRHRSKQFPKRAHWLDWAKEKYDERLIAQIKMVTRVLFLYIPLPMFW
gray_short-tailed_opossum_PepT1|XP_001377037.2 EVAKCIGFAIKNRFKHRSKEFPKREHWLDWAKEKYDERLIAQIKMVVKVMFLYIPLPMFW
platypus_PepT1|XP_001506250.2 QVAGCITFAVKNRFNHRSKTFPKREHWLDWASEKYDERLITQTKMVLKVMFLYIPLPMFW
chicken_PepT1|AAK39954.1 RVCKCIGFAIKNRFRHRSKEYPKREHWLDWASEKYDKRLIAQTKMVLKVLFLYIPLPMFW
turkey_PepT1|AAO16604.1 QVCKCIGFAIKNRFRHRSKEYPKREHWLDWASEKYDKRLIAQTKMVLKVLFLYIPLPMFW
western_clawed_frog_PepT1|XP_002935692.1 KVSKCIGFAIRNRYRNRSKSIPKREHWLDWAKEKYDERLIAQIKMVLKVLFLYIPLPMFW
three-spined_stickleback_PepT1a| DVCKCIGFAIKNRYKHRSSQYPKRQHWMDWAEDKYAKLLIAQIKMVLRVLFLYIPLPMFW
China_rockfish_PepT1a|ABV82968.1 DVCKCIGFAVKNRYRHRSEQHPKRKHWMDWE-EKYEKLLIAQIKMVLKVLFLYIPLPMFW
Nile_tilapia_PepT1a| DVCKCIGFAIKNRYRHRSKQYPKRQHWMDWAEEKYDKLLIAQIKMVLKVLFLYIPLPMFW
Japanese_medaka_PepT1a| SVCKCIGFAIKNRYRHRSKAYPKRKHWMDWAEEKYDRLLIAQIKMVLKVLFLYIPLPMFW
mummichog_PepT1a|AEX92274.1 KVSKCIGFAIKNRYKHRSSQYPKREHWMDWAEEKYDKLLIAQIKISLRVLFLYIPLPMFW
southern_platyfish_PepT1a| KVSKCIGFAIKNRYRHKSKQYPKREHWMDWAEEKYDKLLIAQIKIALRVLVLYIPLPMFW
torafugu_PepT1a| KVCKCIGFAIKNRYRHRSSNYPKREHWMDWAEDKYEKLLIAQIKMVLRVLFLYMPLPMFW
Atlantic_cod_PepT1a| DVCKCIGFAIKNRFRHRGKEFPKRTHWMDWADEKYEKLLIAQIKMVLKVLFLYIPLPMFW
zebrafish_PepT1a|XP_001919914.3 SVCKCIWFALNNRFRHRSDIYPKREHWMDWAEEKYDKLLIAQIKMVLKVLFLYIPLPMFW
Japanese_eel_PepT1a|BAM67012.1 EVSKCIGFAVKNRFRHRSDEYPKREHWMDWAEEKYERLLIAQVKMVLRVLFLYIPLPMFW
common_carp_PepT1b|AEX13747.1 QVMKCIGFAIRNRFNHRSKQHPKREHWMDWAEEEYDKLLIAQVKMVLKVLFLYIPLPMFW
red_crucian_carp_PepT1b|AFI42054.1 QVMNCIGFAVSNRFNHRGKQYPKREHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
red_crucian_x_common_carp_PepT1b|AFI42056.1 QVMKCIGFAIRNRFNHRSKQHPKREHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 QVMKCIGFAIRNRFNHRSKQHPKREHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
grass_carp_PepT1b|AET36827.1 RVMNCIIFALSNRFEHRGKQYPKREHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
zebrafish_PepT1b|AAQ65244.1 QVINCIGFALNNRFRHRGKQYPKREHWMDWAEEKYDKLLIAQVKMVVKVLFLYIPLPMFW
Atlantic_cod_PepT1b|AAY17354.1 EVCKCIWYAVKNRFRNRSSSIPKREHWMDWADEKYEKLLIAQIKMVLKVLFLYIPLPMFW
Atlantic_salmon_PepT1b|BAH24102.1 EVCKCIGFAVKNRFRHRSKKFPKREHWMDWADEKYDKLLVAQVKMVLKVMFLYIPLPMFW
southern_platyfish_PepT1b| KVCKCIFFAIMNRFHNRSSQIPKREHWLDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
mummichog_PepT1b|AEX92273.1 KVCKCIFFAIKNRFRHRSSAYPKREHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
spotted_green_pufferfish_PepT1b| KFCKCVGFAIKNRFRHRSSQYPKRAHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
torafugu_PepT1b| KVCKCIGFAIKNRFRHRASHYPKRAHWMDWAEEKYDKLLIAQVKMVLKVLFLFIPLPMFW
Japanese_medaka_PepT1b| KVTKCIGFAIKNRFRHRSSQYPKREHWMDWADEKYDKLLIAQVKMVLKVLFLYIPLPMFW
Antarctic_icefish_PepT1b|AAO39705.2 KVCTCIGFAVKNRFRHRSSHYPKREHWMDWSDEKYDKLLIAQVKMVLKVLFLYIPLPMFW
three-spined_stickleback_PepT1b| KFFTCIGFAIKNRFRHRTNEFPKRTHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
European_seabass_PepT1b|ACI49693.2 QVCKCIGFAIKNRFRHRAREHPCRTHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
white_grouper_PepT1b|AFP33141.1 KVCKCIGFAIKNRFRHRAPEYPKRTHWMDWAEEKYDKLLIAQVKMVLKVLFLYIPLPMFW
yellow_perch_PepT1b|ACX49753.2 KVCKCIGFAIKNRFRHRGSEYPKRTHWMDWAEEKYSKLLIAQVKMVVRVLFLYIPLPMFW
. *: :*: ** .: * * **:** ::* . *: * *: :*:.*::******
8
%%%%%%%%%%%%%%%% %%%%%%%%%%%%%%%%%%%%%%%%%%%%
################# #######################
human_PepT1|AAB61693.1 ALFDQQGSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFN
chimpanzee_PepT1|XP_522705.3 ALFDQQGSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFN
Rhesus_monkey_PepT1|NP_001028071.1 ALFDQQGSRWTLQAATMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGLN
crab-eating_macaque_PepT1|AAQ56235.1 ALFDQQGSRWTLQAATMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGLN
house_mouse_PepT1|NP_444309.2 ALFDQQGSRWTLQATTMNGKIGAIEIQPDQMQTVNAILIVIMVPIVDAVVYPLIAKCGFN
Norway_rat_PepT1|BAA09318.1 ALFDQQGSRWTLQATTMTGKIGTIEIQPDQMQTVNAILIVIMVPIVDAVVYPLIAKCGFN
dog_PepT1|NP_001003036.1 ALFDQQGSRWTLQATAMSGKIGLLEVQPDQMQTVNAILIVVMVPIMDAVVYPLIAKCGFN
horse_PepT1|XP_001493109.3 ALFDQQGSRWTLQATTMNGQIGVIEIQPDQMQTVNAILIVIMVPIMDAVVYPLIAKCGLN
pig_PepT1|AAO43094.1 ALFDQQGSRWTLQATTMNGQIGLLKIQPDQMQTVNAILIVIMVPIMDAVVYPLIAKCGLN
cattle_PepT1|NP_001092848.1 ALFDQQGSRWTLQATTMSGKIGIIEIQPDQMQTVNAILIVIMVPIVDAVVYPLIAKCGLN
sheep_PepT1|AAK14788.1 ALFDQQGSRWTLQATTMSGKIGIIEIQPDQMQTVNAILIVVMVPIVDAVVYPLIAKCGLN
rabbit_PepT1|AAA17721.1 ALFDQQGSRWTLQATTMSGRIGILEIQPDQMQTVNTILIIILVPIMDAVVYPLIAKCGLN
gray_short-tailed_opossum_PepT1|XP_001377037.2 ALFDQQGSRWTLQATTMNGNFGTIEIQPDQMQTVNAILIVIMVPIVDAVVYPLIAKCGFN
platypus_PepT1|XP_001506250.2 ALFDQQGSRWTLQATTMNGKFGSIEIQPDQMQTVNAILIVVMVPVVDGVIYPLIAKCGFN
chicken_PepT1|AAK39954.1 ALFDQQGSRWTLQATTMDGDFGAMQIQPDQMQTVNPILIIIMVPVVDAVIYPLIQKCKIN
turkey_PepT1|AAO16604.1 ALFDQQGSRWTLQATTMDGDFGALQIQPDQMQTVNPILIIIMVPVVDAVIYPLIQKCKIN
western_clawed_frog_PepT1|XP_002935692.1 ALFDQQGSRWTLQATTMDGNFGAIQIQPDQMQTVNPILIIVLVPIFDAAVYPLIRKCKLD
three-spined_stickleback_PepT1a| TLFDQKGSRWTLQATNLNGNFGLLVIQPDQMQTVNPILILTLVPVMDSIIYPLIRKCGAN
China_rockfish_PepT1a|ABV82968.1 TLFDQKGSRWTLQATAMDGDFGLLVIQPDQMQTVNPILILTLVPIMDSVIYPLIKKCGLN
Nile_tilapia_PepT1a| TLFDQKGSRWTLQATTMNGYFGQLVIQPDQMQTFNPILILTLVPIMDSVIYPLIKKCGFN
Japanese_medaka_PepT1a| TLFDQKGSRWTLQATTMDGNFGQLVIQPDQMQTFNPILILTLVPIMESVVYPLIKKCGFN
mummichog_PepT1a|AEX92274.1 TLFDQKGSRWTLQATTMNGHFGSIVIQPDQMQTINPILILTLVPIMDSLIYPLIRKCGLN
southern_platyfish_PepT1a| TLFDQKGSRWTLQATTMDGNFGSIVIQPDQMQTINPILILTLVPVMDSLVFPLIKKCGLN
torafugu_PepT1a| TLFDQKGSRWTLQATTMNGDYGALVIQPDQMQTFNPILILTLVPIMDSLIYPLIKKCGLN
Atlantic_cod_PepT1a| TLFDQKGSRWTFQATTMDGNFGLLVLQPDQMQTVNPILILTLVPIMDSVVYPLIRKCGLN
zebrafish_PepT1a|XP_001919914.3 TLFDQKGSRWTLQATTMTGDFGGFVLQPDQMQTVNPILILTLVPIMDRIIFPLIKKCGLN
Japanese_eel_PepT1a|BAM67012.1 ALFDQQGSRWTLQATTMDGNFGALIIQPDQMQTVNPILILVLVPIMDSAVYPLIKKCGLN
common_carp_PepT1b|AEX13747.1 ALFDQQGSRWTLQATTMDGNFGAFIIQPDQMQIVNPILIVIMVPIMDSAVYPLIKKCGLN
red_crucian_carp_PepT1b|AFI42054.1 ALFDQQGSRWTLQATTMDGNFGAFIIQPDQMQIVNPILIVIMVPIMDSVVYPLIKKCGLN
red_crucian_x_common_carp_PepT1b|AFI42056.1 ALFDQQGSRWTLQATTMDGNFGAFIIQPDQMQIVNPILIVIMVPIMDSAVYPLIKKCGLN
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 ALFDQQGSRWTLQATTMDGNFGAFIIQPDQMQIVNPILIVIMVPIMDSAVYPLIKKCGLN
grass_carp_PepT1b|AET36827.1 ALFDQQGSRWTIQATTMDGNFGAFIIQPDQMQIVNPILIVIMVPIMDSAVYPLIKMCRIN
zebrafish_PepT1b|AAQ65244.1 ALFDQQGSRWTIQATTMDGNFGGFVIQPDQMQIVNPILIVIMVPIMDSAIYPLIKLCRIN
Atlantic_cod_PepT1b|AAY17354.1 TLFDQQSSRWTLQATTMDGDFGLLVIQPDQMQTVNPILILGFVPIVDSVIYPLIAKCGLN
Atlantic_salmon_PepT1b|BAH24102.1 TLFDQQGSRWTLQATTMDGNFGILTVQPDQMQTVNPILILALVPIMDSLVYPLIKKCHLN
southern_platyfish_PepT1b| ALFDQQGSRWTLQATTMDGNFGLMVIQPDQMQTVNPILILIMVPVMDFIIYPLISKCKLN
mummichog_PepT1b|AEX92273.1 ALFDQQGSRWTLRATTMDGNFGLMVIQPDQMQTVNPILILIMVPVVDFIIYPLISKCKLN
spotted_green_pufferfish_PepT1b| ALFDQQGSRWTLQATTMDGKFGSLEIQPEHMQTVNPILILVLVPIMDTLIYPLISKCKLN
torafugu_PepT1b| ALFDQQGSRWTLQATTMDGNFGSLEIQPEQMQIVNPILILILVPIMDSIVYPLINKCKLN
Japanese_medaka_PepT1b| ALFDQQGSRWTLQATTMDGDFGALTIQPDQMQTVNPILILILVPIMDTLIYPLISKCKLN
Antarctic_icefish_PepT1b|AAO39705.2 ALFDQQGSRWTLQATIMDGDFGFLTIQPDQMQTVNPILILIMVPIMDSAIYPLIAKCNLN
three-spined_stickleback_PepT1b| ALYDQQGSRWTLQATNMDGDFGILTIQPDQMQTINAILILLLVPIVESVIYPLIAKCKIN
European_seabass_PepT1b|ACI49693.2 ALFDQQGSRWTLQATTMDGDFGALIIQPDQMQTVNPILILVLVPIMDSLVYPLISKCKLN
white_grouper_PepT1b|AFP33141.1 ALFDQQGSRWTLQATTMDGDFGLLIIQPDQMQTVNPILILVLVPIMDSLIYPLIAKCKLN
yellow_perch_PepT1b|ACX49753.2 ALFDQQGSRWTLQATTMDGNFGILTIQPDQMQTVNPILILVFVPFVDSVIYPLIAKCKLN
:*:**:.****::*: : * * : :**::** .* ***: :**..: ::*** * :
9
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###########################
human_PepT1|AAB61693.1 FTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGE
chimpanzee_PepT1|XP_522705.3 FTSLKKMTVGMFLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGE
Rhesus_monkey_PepT1|NP_001028071.1 FTSLKKMTVGMFLASLAFVVAAIVQVEIDKTLPVFPKGNEIQIKVLNIGNTTMNISLPGE
crab-eating_macaque_PepT1|AAQ56235.1 FTSLKKMTVGMFLASLAFVVAAIVQVEIDKTLPVFPKGNEIQIKVLNIGNTTMNISLPGE
house_mouse_PepT1|NP_444309.2 FTSLKKMTVGMFLASMAFVVAAIVQVEIDKTLPVFPGGNQVQIKVLNIGNNNMTVHFPGN
Norway_rat_PepT1|BAA09318.1 FTSLKKMTVGMFLASMAFVVAAIVQVEIDKTLPVFPSGNQVQIKVLNIGNNDMAVYFPGK
dog_PepT1|NP_001003036.1 FTSLKRMTVGMFLASMAFVMAAIVQLEIDKTLPVFPKQNEVQIKVLNIGNGAMNVSFPGA
horse_PepT1|XP_001493109.3 FTSLKKMTVGMFLASMAFVAAAIVQVEIDKTLPVFPNGHEVQVKVLNIGNNSMNISFPGE
pig_PepT1|AAO43094.1 FTSLRKMTVGMFLASMAFVAAAIVQVEIDKTLPVFPKGNEVQVKVLNIGNNSMSVSFPGT
cattle_PepT1|NP_001092848.1 FTSLKKMTVGMFLASMAFVAAAIVQVEIDKTLPVFPKGNEVQIKVLNIGDSNMTVSFPGT
sheep_PepT1|AAK14788.1 FTSLKKMTVGMFLASMAFVAAAIVQVDIDKTLPVFPKGNEVQIKVLNIGNNSMTVSFPGT
rabbit_PepT1|AAA17721.1 FTSLKKMTIGMFLASMAFVAAAILQVEIDKTLPVFPKANEVQIKVLNVGSENMIISLPGQ
gray_short-tailed_opossum_PepT1|XP_001377037.2 FTSLKKMTVGMFLASMAFVVAAIIQLQIDKTLPVFPKGNEIQVQVLNVGNENLTAYFPGS
platypus_PepT1|XP_001506250.2 FTSLKKMTVGMFLASMAFVVAAIIQMQIDKTLPVFPTAQEFQVRVVNLGQESMNVIFPGK
chicken_PepT1|AAK39954.1 FTPLRRITVGMFLAGLAFVAAALLQVQIDKTLPVFPAAGQAQIKIINLGDSNANVTFLPN
turkey_PepT1|AAO16604.1 FTPLRKITVGMFLAGLAFIAAALVQVQIDKTLPVFPAAGQAQIRIINLGNSNANVTFLPD
western_clawed_frog_PepT1|XP_002935692.1 FTPLKRMTVGMFLAAMAFVAAALVQIEIDKTLPTFPSSNEFQLKVINLGTKDLNVTYVAN
three-spined_stickleback_PepT1a| FTPLKRMAVGMMMAAIAFVCAAVVQIEIDKTLPTFPSASQSQLKLLNMESNPVTVQLPGL
China_rockfish_PepT1a|ABV82968.1 FTPLKRMTVGMMMAAIAFVCAALVQLQIDQTLPTFPSASQSQLKLLNMGSNQVTVTLPGN
Nile_tilapia_PepT1a| FTPLKRMTVGMFLAAMAFVCAALVQVEIDKTLPVFPSASQSQLKLLNMGSSAVTVNLTGN
Japanese_medaka_PepT1a| FTPLKRMTVGMFLAALAFVCAGVVQLQIDKTLPIFPSTSESQLKLLNMGNNQLEVHLPNN
mummichog_PepT1a|AEX92274.1 FTPLKKMTVGMILAALAFVCAAMVQLQIDKTLPIFPSASQSQLKLLNMENNQLEVHLPNN
southern_platyfish_PepT1a| FTPLKKMTVGMIVAALAFVCAAVIQLQIDKTLPVFPSASQSQLKFLNMGNTQITVQFQGN
torafugu_PepT1a| FTPLKRMTVGMVLAAIAFICAALVQLEIDKTLPTFPSSSQTQIKLVNMNLNSVNVSLPGI
Atlantic_cod_PepT1a| FTPLKRMTVGMFLAAMAFVAAALVQIEIDKTLPVFPSGVQSQLKTINLGRDPMTLTLSQH
zebrafish_PepT1a|XP_001919914.3 FSPLKRMTVGMLFAATAFIAAALVQMEIDKTLPNFPSSSESQLKVVNMHSESLIVTVPSQ
Japanese_eel_PepT1a|BAM67012.1 FTPLRRMTVGMLLAGLAFVAAALVQIEIDKTLPKFPSSSESQLKFLNLGSSQLEITAATN
common_carp_PepT1b|AEX13747.1 FTPLRRMTVGMPLASLAFVAAALLQIQIDRTVPNFPSSSQTQVKFLNLENTPVPVVVEGQ
red_crucian_carp_PepT1b|AFI42054.1 FTPLRRMTVGMVLAALAFVAAALLQIQIDQTVPDFPSNSQTQVKFLNLEETSVPVIVEGQ
red_crucian_x_common_carp_PepT1b|AFI42056.1 FTPLRRMTVGMLLAALAFVAAALLQIQIDRTVPNFPSSSQTQVKFLNLENTPVPVVVEGQ
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 FTPLRRMTVGMLLAALAFVAAALLQIQIDRTVPNFPSSSQTQVKFLNLENTPVPVVVEGQ
grass_carp_PepT1b|AET36827.1 FTPLRKMTVGMLLAALAFVAAALLQIQIDQTMPQFPSSSQTQVKFLNLEKTSLPVLVEGQ
zebrafish_PepT1b|AAQ65244.1 FTPLRKMTVGMVLAALAFVAAALLQLQIDETMPKFPSTSQTQLKFLNVESTSLPVVVEGQ
Atlantic_cod_PepT1b|AAY17354.1 FTPLKRMTVGMFMAALAFIAAALVQLQIDETLPVFPASNGGQIKVFNLAGATVDVSVGGQ
Atlantic_salmon_PepT1b|BAH24102.1 FTPLKRMTVGMLIAALAFVAAALLQLQIDQTLPKLPQGVAGQVKFLNLNSAPLTLTIDGT
southern_platyfish_PepT1b| FTPLRKITVGMFLAGLAFVAAALVQLQIDATLPDFPSSTEQQAKFINMVNRSIDITAGKY
mummichog_PepT1b|AEX92273.1 FTPLRKMTGGMFLAALAFVAAALVQLQIDATLPTFPSSNEQQAKFINMVNRNLSIADGRE
spotted_green_pufferfish_PepT1b| FSPLKRMTVGMLLASVAFVAAALVQLEIDKTLPDFPAGEESQVKFVNMLNEKINFTAGDQ
torafugu_PepT1b| FSPVKRMTVGMFLAAMAFVAAALVQLQIDSTLPNFPKGQESQVKFINMLNTKIDFTAGNK
Japanese_medaka_PepT1b| FTPLRRITVGMFFAAMAFVAAAVVQLQIDKTLPKFPSNSEMQVKFINAVNREVDITAGGH
Antarctic_icefish_PepT1b|AAO39705.2 FSPLKRMTVGMLFAALAFVAAALVQLQIDQTMPIFPSSTESQVKYINMMSTPLDVRAGNN
three-spined_stickleback_PepT1b| FTPLRRITVGMFFAALAFIAAALVEIQIERTLPKFPSSPEVQVKFINMGNKSLDLTAGTN
European_seabass_PepT1b|ACI49693.2 FSPLKRMTVGMFLAALAFIAAALVQIQIDQTLPKFPSSTVGQAKFINMVNRALNINAGPN
white_grouper_PepT1b|AFP33141.1 FTPLKRMTVGMFLAALAFICAALVQIQIDKTPPQFPSSTVGQAKFINMLDRSLDVKAGTN
yellow_perch_PepT1b|ACX49753.2 FTPLKRMTVGMFLAALAFIAAALVQIQIDKTLPQFPSSTVGQAKFINMINRPLDVKAGTN
*: ::::: ** .*. **: *.:::::*: * * :* * : .*
human_PepT1|AAB61693.1 MVTL--GPMSQTNAFMTFDVNKLTRINISSPGSP-VTAVTDDFKQGQRHTLLVWA---PN
chimpanzee_PepT1|XP_522705.3 MVTL--GPMSQTNAFMTFDVNKLTSINISSPGSP-VTAVTDDFKQGQRHTLLVWA---PN
Rhesus_monkey_PepT1|NP_001028071.1 MVTL--DSLSQTNAYMTFDVNKLTSINISSPGSP-VTAVTDDFKQGQRHTLLVWA---PN
crab-eating_macaque_PepT1|AAQ56235.1 MVTL--DSLSQTNAYMTFDVNKLTSINISSPGSP-VTAVTDDFKQGQRHTLLVWA---PN
house_mouse_PepT1|NP_444309.2 SVTL--AQMSQTDTFMTFDIDKLTSINISSSGSPGVTTVAHDFEQGHRHTLLVWN---PS
Norway_rat_PepT1|BAA09318.1 NVTV--AQMSQTDTFMTFDVDQLTSINVSSPGSPGVTTVAHEFEPGHRHTLLVWG---PN
dog_PepT1|NP_001003036.1 VVTV--SQMSQSDGFMTFDVDKLTSINISSTGSP-VIPVTYNFEQGHRHTLLVWA---PN
horse_PepT1|XP_001493109.3 TMAV--NQMSQTGDFMTFDVDKL-SINISSTGSP-VTPVTHNFEQGHRHTILVWA---PN
pig_PepT1|AAO43094.1 TVTL--DQMSQTHEFLTFDVNKLTSINISSAGSP-ATPVTYNFEQGHRHTLLVWG---PS
cattle_PepT1|NP_001092848.1 TETY--NQMSQPKDFMTFNVDNL-SINISSTGSP-VTPVTHNFESGHRHTLLVWA---PS
sheep_PepT1|AAK14788.1 TVTC--DQMSQTNGFLTFNVDNL-SINISSTGTP-VTPVTHNFESGHRHTLLVWA---PS
rabbit_PepT1|AAA17721.1 TVTL--NQMSQTNEFMTFNEDTLTSINITSGSQ--VTMITPSLEAGQRHTLLVWA---PN
gray_short-tailed_opossum_PepT1|XP_001377037.2 EHRN--VSVNESSGFLTLDFNSPPNINISFGQQP-PFQVPNDFERGYRHSILAWN---SS
platypus_PepT1|XP_001506250.2 EAVA--LNLRDKTEFMKLDVNNVNYVVISTAST--IENHTIPFKEGQRQTLLLWS---PS
chicken_PepT1|AAK39954.1 LQNVTVLP-MESTGYRMFESSQLKSVMVNFGSESRSE-NIDSISSNTH-TVTIKNAAAGI
turkey_PepT1|AAO16604.1 LQNVTVLP-MESTNYRIFETSQLKSVIINFGSENRSE-SIDSTSSNTH-TVTIKNAATGI
western_clawed_frog_PepT1|XP_002935692.1 TADSALIPPFKANEYHTLEQSS--SVTFAYGTNTPQPFPLQDLAEQTRYTCVVKDDG-TA
three-spined_stickleback_PepT1a| DPL-LLPAAQASDDFFTFDTETV---GISVG-NS-STVKNITLAKGNRKTLLIT-SSIND
China_rockfish_PepT1a|ABV82968.1 DPL-LLPAAQASDEFFTFDLEII---RVSIG-SP-EETKYIPLAKEKRQTLLIP-SNIAD
Nile_tilapia_PepT1a| ESL-TLNAAQASDKYFTFETEQI---IVSVG-SP-EMTQIIFLEKKSRQTLLIP-SVISD
Japanese_medaka_PepT1a| FTV-HLPPAQASEEYFTYKEQEV---SISIG-NP-PVTETIPLVKGKRQTLLIP-PTIRE
mummichog_PepT1a|AEX92274.1 FTDLLLPAAQASDIQN----KKL---AFQQE-TL-RRPKIISLPDGTRNTIVIVEQGPAF
southern_platyfish_PepT1a| QF--NLTGAQASEEYFTFESDQI---TVSIG-NP-SVSRDVSLTKEQRQTLLIP-SAIND
torafugu_PepT1a| ETPVLLPANQASD-VFTFSDENI---TVSVG-TP-AINQTIQLTKGLRQTLLN----LNQ
Atlantic_cod_PepT1a| TV--QLAPGQAS-DYFTFDEDFV---IVSVD-NT-SISQNLTLAKGKRQSVILP-SNNTQ
zebrafish_PepT1a|XP_001919914.3 EPL-LIGSFESSPDYITFDQQDI---RLAFNTTP-EINKDLSLIKGSRQTLIIPSE--PA
Japanese_eel_PepT1a|BAM67012.1 APL-TVPPFQANPEYLPFSENEI---QVSTG-V--GFTQNIMLEKGKRQTLLINPA--TN
common_carp_PepT1b|AEX13747.1 EPF-VVPGFNSSNNYMTLDTENV---TVSAG----GRDATAYFQKESRHTVLINADRM--
red_crucian_carp_PepT1b|AFI42054.1 EPF-VVPGFDSSNDYMTLDKMVV---MVSAG----DRNATAIFVRGKRQTVLMNANGM--
red_crucian_x_common_carp_PepT1b|AFI42056.1 EPF-VAPGFNSSNNYMTLDTENV---TVSAG----GRNATAYFQKESRHTVLINADGM--
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 EPF-VVPGFNSSNNYMTLDTENV---TVSAG----GRNATAYFQKESRHTVLINADGM--
grass_carp_PepT1b|AET36827.1 EQF-FVPGFNSSNEYMTLDTMNV---TVSVG----GRNETGYFLNKMRHTVLINAGGM--
zebrafish_PepT1b|AAQ65244.1 DQF-MVPGFNASSEYLTLDKENV---TISAG----GVNDTAFLKTGTRHTVLMNAAGM--
Atlantic_cod_PepT1b|AAY17354.1 NF-TLD-PFMSNSKYLSFEGKI----NIDINKT--SMPL--VLTNGTRRSVVIDQTF--P
Atlantic_salmon_PepT1b|BAH24102.1 IDVSVPAHQVNTGDYLTFDKSV----RVVFNKNT-STGTDLILMSQTRRTALVSPTL---
southern_platyfish_PepT1b| AF-QLQ-TLQGNEEYYTYNLPF----DLTIDSGP-TETI--RLPGGTRNTIVIVEEAGRM
mummichog_PepT1b|AEX92273.1 NF-HLG-AFEGRQDYLTYTEPF----LLTINSGS-PNLI--SLPDGTRNTIVIVEQGPAF
spotted_green_pufferfish_PepT1b| PF-SME-PFTARDNYTTFTGAF----NLSLGPGN-SNEI--RFNGSTRNTLEIIQESDSP
torafugu_PepT1b| PF-SME-PFTGRDNYTSFTEPF----QLDLGPSA-SEVV--TLENGTRNTLVIIQERAAP
Japanese_medaka_PepT1b| VL-PLK-PLTATETYETFKNPF----LLTVGD-Y-EYAV--SFPKGTRNTITIVQNETEL
Antarctic_icefish_PepT1b|AAO39705.2 NF-TLK-PFTANEDYLTFGSPF----ALLLGPNA-SFPI--AIEEGNRSTSVIVQEGTRP
three-spined_stickleback_PepT1b| KV-TLE-AFTANADYLTFEQHF----DLTVGSDF-NYST--TLTPGSRNTMVIFPDTTPP
European_seabass_PepT1b|ACI49693.2 SF-TLE-SYKANEEYFNFNGPF----KLNLGSGN-AFLG--NIPAGTRATIVIIQDGTKP
white_grouper_PepT1b|AFP33141.1 EF-TLK-PYTANDDYLTFDDPF----LLNLGGNA-TYLT--GLVDGNRSTVVIVQDGPLP
yellow_perch_PepT1b|ACX49753.2 EF-TLQ-PFRANEDYLNFDDTF----ELTLRPNA-TSNI--SLENGNRSTGVIVEDWS--
. : :
human_PepT1|AAB61693.1 HYQVVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIK--
chimpanzee_PepT1|XP_522705.3 HYQVVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANISSYSASTYQFFPSGIK--
Rhesus_monkey_PepT1|NP_001028071.1 HYRVVKDDLNQKPKKGENGIRFVNTFNELITVTMSGKIYANVSSNNASNYQFFPSGVK--
crab-eating_macaque_PepT1|AAQ56235.1 HYRVVKDDLNQKPKKGENGIRFVNTFNELITVTMSGKIYANVSSNNASNYQFFPSGIK--
house_mouse_PepT1|NP_444309.2 QYRVVKDGLNQKPEKGENGIRFVNTLNEMVTIKMSGKVYENVTSHNASGYQFFPSGEK--
Norway_rat_PepT1|BAA09318.1 LYRVVKDGLNQKPEKGENGIRFVSTLNEMITIKMSGKVYENVTSHSASNYQFFPSGQK--
dog_PepT1|NP_001003036.1 NYRVVKDGLNQKPEKGENGIRFINSLNESLNITMGDKVYVNVTSHNASEYQFFSLGTK--
horse_PepT1|XP_001493109.3 HYRVIKDGLDRKPEKGQNGIRFVNAFDKSFDVTMDGTVYVNVTSHSASEYQFFPSGKK--
pig_PepT1|AAO43094.1 HYRVVKDGLNQKPEKGENGVRFVNTFDESFNVTMDGKVYIDVTSHNASAYQFFPSGAK--
cattle_PepT1|NP_001092848.1 NYQVVKDGLNQKPEKGRNGIRFVNAFGESFNVTMDGEVYNNVSSHNASEYLFFSSGVK--
sheep_PepT1|AAK14788.1 NYQVVKDGLNQKPEKGRNGIRFVNAFGESFGVTMDGEVYNNVSGHNASEYLFFSSGVK--
rabbit_PepT1|AAA17721.1 NYRVVNDGLTQKSDKGENGIRFVNTYSQPINVTMSGKVYEHIASYNASEYQFFTSGVK--
gray_short-tailed_opossum_PepT1|XP_001377037.2 YFVTLKDSLKTKPEKGLNGIRFVNNLDRTINISMDGKTYLNIAPKNASDYEFFSSGEK--
platypus_PepT1|XP_001506250.2 EFTLLENDLNKKPEKGLNGIRFINAMNKSINITVAGSNFQDVLPRNASEYEFFPSGVK--
chicken_PepT1|AAK39954.1 VSSLRSDNFTSKPEEGKNLVRFVNNLPQTVNITMGDTTFGILEETSISNYSPFSGGRT--
turkey_PepT1|AAO16604.1 VSSLRSDNFTSKPEEGKNLIRFVNNLPQTVNITMGDTDFGILEETSISNYTLFSGGRT--
western_clawed_frog_PepT1|XP_002935692.1 IQANVFEDISAKPDQGSNAIRFVNGMQEPINVTLNAVSLGQLMPLQISNYTMQKLGIK--
three-spined_stickleback_PepT1a| N-WVLTNDLISKPQEGNNEIRFINGLSTTINVSAPAADFGVIESFYYSNYSKIKTGKT--
China_rockfish_PepT1a|ABV82968.1 E-WLLTDDLTAKPEEGNNAIRFINGMNAAVNVSTPAAHFGLIESFYYSNYSQITNNYSQI
Nile_tilapia_PepT1a| E-WLLTKDLTSKPEQGNNEIRFVNGMNMPVNVTTSAVDLGLIEPFYYSNYSKIKNGEN--
Japanese_medaka_PepT1a| E-WVLIDDLTSKPEEGNNAIRFVNGLATDLNVSTAAVNFGIIEPLTSSNYSLLKNGKH--
mummichog_PepT1a|AEX92274.1 G-YITIDDLTSKPEEGNNAIRFVNGLATDINVSAPAADFGVIESFYMSIYSLLKTGTKT-
southern_platyfish_PepT1a| D-WQLAYDLIYKPQEGNNEIRFINGMSTPVNVSSAAVHYDQIEPLHYSNYSEIKNGRA--
torafugu_PepT1a| K-WALSNDLISKPEKGQNSVRFINGMNQIVNISTSEVDFGKIEPFLYSNYTLLKNGMT--
Atlantic_cod_PepT1a| E-WPMTEDLTAKPEQGANAIRFVSGT-YPLNISTGGLDFGITDGSLYSNYSLLTYGST--
zebrafish_PepT1a|XP_001919914.3 E-MYLKEDIKSKPKEGKNAVRFVNGWTAYLNITNLESS---LQPSETSNYTLVSQGMR--
Japanese_eel_PepT1a|BAM67012.1 T-MEAINDLMAKPEQGDNAIRFVNGLGTMVNVTTAAVDFGVIAPSSVSNYTLLHEGKS--
common_carp_PepT1b|AEX13747.1 --LQTLNDITEKPNQGMNAIRFVNGFRSHLNFSVKSDHLGPIAPLQASDYFSVTHGKA--
red_crucian_carp_PepT1b|AFI42054.1 --QSILNDITEKPNQGMNAIRFVNGFRSPLNFSIKSDHLGSIAYLQASDYLIVTHGKA--
red_crucian_x_common_carp_PepT1b|AFI42056.1 --LQTLNDITEKPNQGMNAIRFVNGFRSHLNFSVKSDHLGPIAPLQASDYFSVTHGKA--
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 --LQTLNDITEKPNQGMNAIRFVNGFRSHLNFSVKSDHLGHIAPLQASDYFSVTHGKA--
grass_carp_PepT1b|AET36827.1 --IQTLNDITDKPSQGGNAIRFVNGFRTQLNITVKSGDLGFLSPLEGSSYLMVPHGKA--
zebrafish_PepT1b|AAQ65244.1 --RNTLDDLTEKPEQGLNAIRFVNGWENRLNVSVKSDNVH-ADPLDASVYLLVPHGKV--
Atlantic_cod_PepT1b|AAY17354.1 N-SISYEDMTAKPEQGENAIRFLNGLGENVNVT----SLGNIPSMKMSKYALVQQGSA--
Atlantic_salmon_PepT1b|BAH24102.1 -DMNLVYDLSKKPDDGMNAIRFVNGLGSALNVTLG---VGDIAPLAVSNYSLVPQGKA--
southern_platyfish_PepT1b| TN-IKFGDVVAKPEEGANAIRFFNGFGMTLNITVGEEGFGNIVSKNMSTYVDVPQGTA--
mummichog_PepT1b|AEX92273.1 GY-ITFQDIVAKPEEGANAIRFFNGYGSVLNITVGDQEYGDIVPNNMSIFINVPQGTG--
spotted_green_pufferfish_PepT1b| HVLAAFSDINKKPEKGKNAIRVLTASARRINVTARENDFGFTVPNNMSAYQLLHSGDV--
torafugu_PepT1b| AY-ITFKDINEKPAKAANAIRIFNGFNETINVTSGEQDFGYSVPNNMSEYRLLHSGHV--
Japanese_medaka_PepT1b| GA-IPFEDITKKPEQGANAIRFFNGFDTALNVTVGDKEIGYIHPNNMSEYTSVKRGYA--
Antarctic_icefish_PepT1b|AAO39705.2 TP-ITFSDTTSKPEQGANAIRFFNGFNMTLNMTWGDQSFGNIPTNDMSTYVLIPQGVA--
three-spined_stickleback_PepT1b| KL-MPFTDINAKPEQGANAIRFFNGLDSDLNVTIGNLDFGDVSANNMSVYVGVPKGSA--
European_seabass_PepT1b|ACI49693.2 RP-TQFRDIKSKPEQGTNAIRFLNGFGSVLNATVGTLEFGNTITNNMSEYISVPQGNA--
white_grouper_PepT1b|AFP33141.1 KP-LGFVDIKTKPEQGANDIRFLNGYDSLLNVTVGDQDFGEITTNSMSKYVGVPRGPA--
yellow_perch_PepT1b|ACX49753.2 PP-VWFTDTKSKPEQGANTIRFLNGLGSDLNVTAGNLFFWVVNKNDMSNYVAVPQGLA--
* .. * :*... . . * :
human_PepT1|AAB61693.1 ----GFTISST-EIPPQCQPNFNTFYLEFGSAYTYIVQ-RKNDS---CP-EVKVFEDISA
chimpanzee_PepT1|XP_522705.3 ----GFTISST-EIPPQCQPNFNTFYLEFGSAYTYIVQ-RKNDS---CP-EVKAFEDISA
Rhesus_monkey_PepT1|NP_001028071.1 ----GFTISST-EIPPQCQSNFNTFYLEFGSAYTYLVR-RKNGS---CP-EVQSFEDISA
crab-eating_macaque_PepT1|AAQ56235.1 ----GFTISST-EIPPQCQPNFHTHYLEFGSAYTYLVR-RKNGS---CP-EVRSFEDISA
house_mouse_PepT1|NP_444309.2 ----QYTINTT-AVAPTCLTDFKSSNLDFGSAYTYVIR-RASDG---CL-EVKEFEDIPP
Norway_rat_PepT1|BAA09318.1 ----DYTINTT-EIAPNCSSDFKSSNLDFGSAYTYVIRSRASDG---CL-EVKEFEDIPP
dog_PepT1|NP_001003036.1 ----NITISSTQQISQNCTKVLQSSNLEFGSAYTYVIG-TQSTG---CP-ELHMFEDISP
horse_PepT1|XP_001493109.3 ----SFTINST-EISQQCERNFTSPRLGFGSAYTYVMG-RKADG---CP-ELSVFGDIPP
pig_PepT1|AAO43094.1 ----SFIVHSP-EISPQCKNNFTSSSLEFGSAFTYVIT-RKEDS---CP-DLKIFEDISP
cattle_PepT1|NP_001092848.1 ----SFTINSP-EISQPCGKEFKTPYLGFGSAFTYVIT-RKSDG---CP-EAKAFEDISP
sheep_PepT1|AAK14788.1 ----SFTINSP-EISQQCEKQFKTSYLEFGSAFTYVIS-RKSDG---CP-EPKIFEDISP
rabbit_PepT1|AAA17721.1 ----GFTVSSA-GISEQCRRDFESPYLEFGSAYTYLIT-SQATG---CP-QVTEFEDIPP
gray_short-tailed_opossum_PepT1|XP_001377037.2 ----TIEIKG------VCS--GKSPRLEFGSAYTYVITKCD-TN---GL-ALKTFNDIPA
platypus_PepT1|XP_001506250.2 ----TIMINDK-----QCE--GKTGKLSFGSAYTLVVTKCE-NG---ES-NIIDIEDLSP
chicken_PepT1|AAK39954.1 ----YDIVITAG--STNCK--PTSEKLGYGGAYTIVINECS-GD---VT-QLRYIEDIQP
turkey_PepT1|AAO16604.1 ----DDIVIVAD--STNCT--VTSEALGYGGAYTIIINECS-ED---VT-QLRYIEDIQP
western_clawed_frog_PepT1|XP_002935692.1 ----EIEVFTAS--GKTWK--VESIKFGFGSSYTIIIKEGN-TE----L-QVEYVEDIQP
three-spined_stickleback_PepT1a| ----IFTI-RSG--SQSCE---YSRDFGFGSSYTFFIPSTFVFG-PNCQESVTVAEDIKP
China_rockfish_PepT1a|ABV82968.1 TNKVHHTI-QSG--SQSCE---YSRDFGFGSSYTLFIPSTLIFG-QNCQESVTAAEDIKP
Nile_tilapia_PepT1a| ----KFSL-SSG--SQSCE---YIKDFGFGSSYTFFIPSTFVFG-PNCQDSITVVEDIEP
Japanese_medaka_PepT1a| ----TFSL-KSG--SQSCE---YTIKFGFGSSYTIFIPSTFTFG-PNCQESVTEVEEIKP
mummichog_PepT1a|AEX92274.1 ----IFTK-NNV--KQSCE---YSRDFGFGSSYTFFIPSTFVFG-PNCQESVTEVENIGP
southern_platyfish_PepT1a| ----TFTL-QSG--SQSCE---YSKDFGFGGSYTFFIPSTLTFE-PNCHESITESVDIKP
torafugu_PepT1a| ----NFTI-KTA--RQSCY---WTRDFGFGSSYSFFIHSNFSFE-PDCSKSITEIEYIKP
Atlantic_cod_PepT1a| ----VFTI-ESG--GESCK---YSREFGFGSSYTLIIPSSFTFG-PDCAASIGVAEDIKP
zebrafish_PepT1a|XP_001919914.3 ----KFTL-TDG--IQSCE---FSRKFGFGSSYTFLIPSDL-FS-TDC-ESIKEIEDMQP
Japanese_eel_PepT1a|BAM67012.1 ----TFTLTSEG--GQTCQ---FSKTYKFGSSYTLVIPSDIQWT-ENCGDTIKESLDIKP
common_carp_PepT1b|AEX13747.1 ----SFTIENEE--GQTCH---YILQLGFGSSYTVLIPNTFTFG-ESCTENIKAIQDINP
red_crucian_carp_PepT1b|AFI42054.1 ----NFSIVNQE--GQTCH---YILQLGFGSSYTVLISSNFTFG-ESCTENIKAVEDIEP
red_crucian_x_common_carp_PepT1b|AFI42056.1 ----SFTIENEE--GQTCH---YILQLGFGSSYTVLIPNTFTFG-ESCTENIKAVQDINP
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 ----SFTIENEE--GQTCH---YILQLGFGSSYTVLTQTPLL-W-RICTENIKAMQDINP
grass_carp_PepT1b|AET36827.1 ----NFTIGNEN--GQNCT---YIMQLGFGSSYTVLIPSTFSFG-QNCNNTITAVQDIEP
zebrafish_PepT1b|AAQ65244.1 ----NFTIFDGG--DGKCH---YIMQLGFGSTYTVLIPSTFAFG-QTCSESFEAVQDMEP
Atlantic_cod_PepT1b|AAY17354.1 ----QFDIQTVN--G-KCT---YSIAVGFGSAYTVIIPDTFTIA-D-CG-GLRPEEDIGP
Atlantic_salmon_PepT1b|BAH24102.1 ----EFTIMNSG--GASCL---YSIDLGFGSAFTLLIPSTFTIGSPDCWQAIQVVEDIQP
southern_platyfish_PepT1b| ----EFVIKNAA--GSTCA---FKREFGFGSSYTFIIPPTFILE-ENCEEHIKEVEDIKA
mummichog_PepT1b|AEX92273.1 ----KFFMKNNG--GVECV---FSRKFGFGSSYTFLIPPTFVFG-EHCGESIKEVENIKP
spotted_green_pufferfish_PepT1b| ----NYKIMTAS--GRSCV---FSQTLKYGSSYTIFIRPDIKFE-EQCTG-VHAVMDISP
torafugu_PepT1b| ----NYKIMTMD--GRSCL---FSQTLKYGSSYTLVVQPNITFE-EQCSN-ILVLMDISP
Japanese_medaka_PepT1b| ----GYWIRNDA--GLECF---VKQELGFGSSYTLLIPPTLTFE-VNCSEGVQKILDIEP
Antarctic_icefish_PepT1b|AAO39705.2 ----QYQIKNAL--GSVCD---YKQELGFGSSYTIVIPPTFNFG-STCEQILIPVVDIKP
three-spined_stickleback_PepT1b| ----QFKIKSA---AEECV---YTQELGFGSSFTLIIPPTFAFG-SNCEQSIRPVLDMEQ
European_seabass_PepT1b|ACI49693.2 ----QFHIRDNS--GQECV---YTQKLGFGSSYTLIIPPTFAFG-PNCENSIQPVVDIKP
white_grouper_PepT1b|AFP33141.1 ----KFLIKSTT--GQECV---YSQELGFGSSFTLIIPPTFTFG-QNCEQNIHPVMDIKP
yellow_perch_PepT1b|ACX49753.2 ----KFQIKNDA--GQECN---YDYNLGFGSSITFIIPTIFTFG-PDCGLSIHPVIDIKP
:*.: : . :
10 11
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% %%%%%%%%%%%%%%%%%%%
################################ ######################
human_PepT1|AAB61693.1 NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
chimpanzee_PepT1|XP_522705.3 NTVNMALQIPQYCLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
Rhesus_monkey_PepT1|NP_001028071.1 NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAIGNIIVLIV
crab-eating_macaque_PepT1|AAQ56235.1 NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAIGNIIVLIV
house_mouse_PepT1|NP_444309.2 NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
Norway_rat_PepT1|BAA09318.1 NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAIGNIIVLIV
dog_PepT1|NP_001003036.1 NTVNMALQIPQYFLITCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
horse_PepT1|XP_001493109.3 NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
pig_PepT1|AAO43094.1 NTINMALQIPQYFLITCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
cattle_PepT1|NP_001092848.1 NTVSMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
sheep_PepT1|AAK14788.1 NTVSMALQIPQYFLLTCGEVVFSITGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
rabbit_PepT1|AAA17721.1 NTMNMAWQIPQYFLITSGEVVFSITGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
gray_short-tailed_opossum_PepT1|XP_001377037.2 NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
platypus_PepT1|XP_001506250.2 NSVSMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
chicken_PepT1|AAK39954.1 NTVHMAWQIPQYFILTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
turkey_PepT1|AAO16604.1 NTVHMAWQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAFGNIIVLIV
western_clawed_frog_PepT1|XP_002935692.1 NTIHMALQIPQYFLITAGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
three-spined_stickleback_PepT1a| NSVHMALQIPQYFFITVGEVMFSVTGLEFSYSQAPSNMKAVLQAGWLLTVAVGNFIVLIV
China_rockfish_PepT1a|ABV82968.1 NSAHMALQIPQYFFITAGEVMFSVTGLEFSYSQAPSNMKAVLQAGWLFTVAIGNFIVLIV
Nile_tilapia_PepT1a| NSVHMALQIPQYFFITAGEVMFSVTGLEFSYSQAPSNMKAVLQAGWLFTVAVGNFIVLIV
Japanese_medaka_PepT1a| NSVHMALQIPQYFLITAGEVMFSVTGLEFSYSQAPSNMKAVLQAGWLLTVAVGNFIVLIV
mummichog_PepT1a|AEX92274.1 NTVHMALQIPQYFFITVGEVMFSVTGLEFSYSQAPSNMKAVLQAGWLLTVAVGNFIVLIV
southern_platyfish_PepT1a| NSVHMALQIPQYFLITAGEVMFSVTGLEFSYSQAPSNMKSVLQAGWLLTNSFGNFIVLIV
torafugu_PepT1a| NTAHMALQIPQYFFITAGEVMFSVTGLEFSYSQAPNNMKAVLQAGWLLTVAVGNFIVLIV
Atlantic_cod_PepT1a| NSVHMALQIPQYFLITAGEVVFSVTGLEFSYSQAPSNMKAVLQAGWLFTVAIGNFIVLIV
zebrafish_PepT1a|XP_001919914.3 NSVHMALQIPQYFLITTGEVMFSVTGLQFSYSQAPKNMKSVLQAGWLCTNAVGNIIVLIV
Japanese_eel_PepT1a|BAM67012.1 NTIHMAWQIPQYFLITSGEVVFSVTGLEFSYSQAPSNMKAVLQAGWLFTVAVGNIVVLIV
common_carp_PepT1b|AEX13747.1 NDIHMAWQVIQYFLMTCGEVVFSVTGLDFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
red_crucian_carp_PepT1b|AFI42054.1 NGIHMAWQIIQYFLITCGEVVFSVTGLDFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
red_crucian_x_common_carp_PepT1b|AFI42056.1 NDIHMAWQVIQYFLMTCGEVVFSVTGLDFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 NDIHMAWQVIQYFLMTCGEVVFSVTGLDFSYSQAPSNMKSVLQAGWPLTVAVGNIIVLIV
grass_carp_PepT1b|AET36827.1 NSVHMAWQIPQYVFLTAGEVMFSITGLEFSYSQAPASMKSVLQAGWLMTVAFGNVIVLIV
zebrafish_PepT1b|AAQ65244.1 NRIHMAWQVIQYFLLTCGEVVYSVTGLDFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
Atlantic_cod_PepT1b|AAY17354.1 NVVHMAWQIPQYFLMTMGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLFTVAVGNIIVLIV
Atlantic_salmon_PepT1b|BAH24102.1 NTIHMGWQIPQYFLMTGGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLFTVAVGNIIVLIV
southern_platyfish_PepT1b| NSIHMAWQIPQYFLMTSGEVVFSVTGLEFSYSQAPSNMKAVLQAGWLLTVAVGNIIVLIV
mummichog_PepT1b|AEX92273.1 NSIHMAWQIPQYFLMTSGEVFFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
spotted_green_pufferfish_PepT1b| NTVTLALQIPQYFFITAGEVVFSVTGLEFAYSQSPSNMKAVLQAGWLLTVAVGNIIVLIV
torafugu_PepT1b| NTLSLALQIPQYFLITAGEVVFSVTGLEFAYSQSPSNMKSVLQAGWLLTVAVGNIIVLII
Japanese_medaka_PepT1b| NTFSMAWQIPQYFLLTAGEVVFSVTGLEFSYSQAPSNMKAVLQAGWLLTVAFGNIIVLIV
Antarctic_icefish_PepT1b|AAO39705.2 NIIHMAWQIPQYFLMTVGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIVVLII
three-spined_stickleback_PepT1b| NSFHMAWQIPQYFLLTLGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIVVLIV
European_seabass_PepT1b|ACI49693.2 NTIHMAWQIPQYFLITAGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIV
white_grouper_PepT1b|AFP33141.1 NTIHMAWQIPQYFLITAGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLFTVAVGNIIVLIV
yellow_perch_PepT1b|ACX49753.2 NTIHMAWQIPQYFLITAGEVIFSVTGLEFAYSQAPSNVKSVLQAGWLLTVAVGNIIVLIV
* :. *: ** ::* ***.:*:***:*:***:* .:*:****** * :.**.:***:
12
%%%%%% %%%%%%%%%%%%%%%%%%%%%%%%%%%%
###### #######################
human_PepT1|AAB61693.1 AGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKNRLEK---
chimpanzee_PepT1|XP_522705.3 AGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKNRLEK---
Rhesus_monkey_PepT1|NP_001028071.1 AGAGQFSKQWAEYILFAALLLVVCIIFAIMTRFYTYINPAEIEAQFGEDEKKKSLEN---
crab-eating_macaque_PepT1|AAQ56235.1 AGAGQFSKQWAEYILFAALLLVVCIIFAIMTRFYTYINPAEIEAQFDEDEKKKSLEN---
house_mouse_PepT1|NP_444309.2 AGAGHFPKQWAEYILFASLLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKKGIGK---
Norway_rat_PepT1|BAA09318.1 AEAGHFDKQWAEYVLFASLLLVVCIIFAIMARFYTYINPAEIEAQFDEDEKKKGVGK---
dog_PepT1|NP_001003036.1 AGAGQFSEQWAEYILFAALLLVVCVIFAIMARFYTYVNPAEIEAQFDDDEK-KNLEK---
horse_PepT1|XP_001493109.3 AGAGQFSKQWAEYILFAALLLVVCVIFGIMAQFYTYVNPAEVEAKFDDDEKKKNPEK---
pig_PepT1|AAO43094.1 AGAGQFSEQWAEYVLFAGLLLAVCIIFAIMARFYTYINPAEVEAQFDMDEKKKYLGK---
cattle_PepT1|NP_001092848.1 AGAGQFSEQWAEYVLFAALLLVVCVIFAIMARFYTYINPAEVEAQFDKDDKEDYLEK---
sheep_PepT1|AAK14788.1 AGAGQFSEQWAEYVLFAALLLVVCIIFAIMARFYTYVNPAEIEAQFDEDDKEDDLEK---
rabbit_PepT1|AAA17721.1 AGAGQINKQWAEYILFAALLLVVCVIFAIMARFYTYVNPAEIEAQFEEDEKKKNPEK---
gray_short-tailed_opossum_PepT1|XP_001377037.2 AGAGQFSEQWAEYILFAALLLAVCIIFAIMAYYYTYVNPAEIEAQFDDDEDKKRNGRKAG
platypus_PepT1|XP_001506250.2 AGAGQFSEQWVEYFLFAGLLLVVCVIFAIMAYYYQYVNPAEIEAQFDEDEKKKTGDLQPN
chicken_PepT1|AAK39954.1 AGASKLSEQWAEYVLFAALLFAVCIIFAVMAYFYTYTDPNEVEAQLDEEEKKKQIKQDPD
turkey_PepT1|AAO16604.1 AGASKLSEQWAEYVLFAALLFAVCIIFAVMAYFYTYIDPNEVEAQLDEEEKKKQIKQDPD
western_clawed_frog_PepT1|XP_002935692.1 AGASHISQQWAEYVLFAALLVAVCIIFAVMAYFYTYVDPAEIEAQFDEEEKKKNAKEIEA
three-spined_stickleback_PepT1a| AELAKLPKQWAEYILFASLLVVVCVIFSIMAHFYTYIDPAEIEAQFNKKVDEVEEEEDD-
China_rockfish_PepT1a|ABV82968.1 AEVAKIRKRWVEYVLFASLLVAVCFIFSIMAHFYTYTDPTEIEAQFRKKVDKDDEDDKS-
Nile_tilapia_PepT1a| AEIAKLPNKWAEYVLFASLLVLVCIIFSIMAYFYTYIDPSEIEVQFRKKVDDDE-DDKD-
Japanese_medaka_PepT1a| AEIAKLPKKWAEFFLFASLLVAVCVIFSIMAYFYTYIDPTEIEAQFSQEKDEEDEDEKD-
mummichog_PepT1a|AEX92274.1 AELAKFPKQWAEYFLFASLLVVVCVIFSIMAYFYTYIDPAKIEAQFKKKVDEEEEEEES-
southern_platyfish_PepT1a| AEIAKLPKQWTEYILFASLLVAVSIIFSIMASFYTYIDPTAIEAEFKKKIHDDEDDKKK-
torafugu_PepT1a| AEIAKLPEQWTEYILFASLLLVVCVIFSVMAYFYTYIDPAEIEAQFRKTTDDDEEDYKF-
Atlantic_cod_PepT1a| AELAQIPEQWAEYVLFASLLVAVCVIFSIMAHFYTYMDPAEIEAQFRKKDDDHEVRAEK-
zebrafish_PepT1a|XP_001919914.3 AELGKLPKQWAEYVLFASLLVAVSIIFSIMAYFYTYIDPAEIEAEILKQQETDPDKKKK-
Japanese_eel_PepT1a|BAM67012.1 AEAAQIPEQWAEYILFAALLIAVCVIFAVMAYFYTYVDPTEIEAQFQKDDSETEKEKEKE
common_carp_PepT1b|AEX13747.1 AEAGSLPEQWAEYVLFACLLVAVSIIFAVMAYFYTYMDPAEIEAKFMELEPDDKKRKELE
red_crucian_carp_PepT1b|AFI42054.1 AEAGSLPDQWAEYVLFACLLVAVSIIFAVMAYFYTYIDPAEIEAKFMEIKPEDEKKKGLE
red_crucian_x_common_carp_PepT1b|AFI42056.1 AEAGSLPDQWAEYVLFACLLVAVSIIFAVMAYFYTYIDPAEVEAKFMELKPEDEKKKGLE
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 AEAGSLPEQWAEYVLFACLLVAVSIIFAVMAYFYTYMDPAEIEAKFMELEPEDKKRKELE
grass_carp_PepT1b|AET36827.1 AEGA-GMEQWVEFILFAALLVAVSIIFSIMAYFYTYVDADQLDKIYGADTKDE-KVKSSD
zebrafish_PepT1b|AAQ65244.1 AEAGSLPDQWAEYLLFASLLVAVSIIFAIMAYFYTYIDPNEIEAKFKELEPEDKKRKEMQ
Atlantic_cod_PepT1b|AAY17354.1 AEVAQLPDQWAEYVLFAALLIFVCVVFSIMAYFYTYTDPAEVEARFAELEPEGKDNDRK-
Atlantic_salmon_PepT1b|BAH24102.1 AEAAQLPDQWAEYILFASLLVVVCIVFAIMSYFYTYTDPAEIEAEFRQPEHGPERKR---
southern_platyfish_PepT1b| AEAATLPDQWAEYVLFAALLVLVCIIFAIMAYFYTYIDPVQIEADFANLEPEDEK-K---
mummichog_PepT1b|AEX92273.1 AEAATLPDQWAEYILFSSLLVLVCIIFAIMAYFYTYTDPAKIEALFANPEPDDKE-K---
spotted_green_pufferfish_PepT1b| AEAATLEEQWAEYILFASLLVLVCIIFAIMAYFYTYIDPVKIESQFAHCEPEEEK-K---
torafugu_PepT1b| SQAARLEEKWAEYILFASLLVVVCVIFAIMGYFYTYIDPVKIESQFSQSESEEEK-R---
Japanese_medaka_PepT1b| AEAATLEDQWAEYILFAALLVLVCIIFAIMAYFYTYIDPAKIEAHFANMEYGEKERK---
Antarctic_icefish_PepT1b|AAO39705.2 AEAATLEDQWAEYILFASLLVLVCFIFAFMAYFYTYIDPAKIEAEFAHKEPEEEKKR---
three-spined_stickleback_PepT1b| AEAATLQDQWAEYVLFASLLLVVCVIFAIMAYFYTYIDPAKIEAEFAQIDPKQKEKR---
European_seabass_PepT1b|ACI49693.2 AEAATLPDQWAEYILFASLLILVCIIFAVMAYFYTYLDPAKIEAEFAHEEPEDKEKR---
white_grouper_PepT1b|AFP33141.1 AEAATLPDQWAEYILFASLLLLVCFIFAFMAYFYTYIDPTQEEARFTQKEPEEKERK---
yellow_perch_PepT1b|ACX49753.2 AEAATLSDQWAEYILFASLLLVVCVVFAIMAHFYTYIDPTKIEAQFAEKDPEDKEKR---
: . .:*.*:.**: **. *..:*..* :* * : :
human_PepT1|AAB61693.1 -----SNPYFM------SGA
chimpanzee_PepT1|XP_522705.3 -----SNPYFM------SGA
Rhesus_monkey_PepT1|NP_001028071.1 -----SNPYIM------LGA
crab-eating_macaque_PepT1|AAQ56235.1 -----SNPYIM------LGA
house_mouse_PepT1|NP_444309.2 -----ENPYSS------LEP
Norway_rat_PepT1|BAA09318.1 -----ENPYSS------LEP
dog_PepT1|NP_001003036.1 -----MNVYST------VTP
horse_PepT1|XP_001493109.3 -----ENPYYT------LDS
pig_PepT1|AAO43094.1 -----DSLYPK------LDT
cattle_PepT1|NP_001092848.1 -----SNPYAK------LDS
sheep_PepT1|AAK14788.1 -----SNPYAK------LDF
rabbit_PepT1|AAA17721.1 -----NDLYPS------LAP
gray_short-tailed_opossum_PepT1|XP_001377037.2 VV---SDPYEK------PDS
platypus_PepT1|XP_001506250.2 ------NQNEK------PNT
chicken_PepT1|AAK39954.1 LH---G--KES------EA-
turkey_PepT1|AAO16604.1 LY---G--KES------EA-
western_clawed_frog_PepT1|XP_002935692.1 MG---V--QNG------DGP
three-spined_stickleback_PepT1a| KSELQKLEMAKKG--SIKSH------EDEDDADKR-
China_rockfish_PepT1a|ABV82968.1 QHEKAEFEMVKKD--SFKSH------DDEDEYEHDK
Nile_tilapia_PepT1a| KQQKAEIEMVRRD--SAESY------DDNY--K---
Japanese_medaka_PepT1a| KMRKTEEHVTKRG--SVKSN------DSDNAFKLSK
mummichog_PepT1a|AEX92274.1 KLEMNAWPEIHATRSSGKQL------KRGGRLK---
southern_platyfish_PepT1a| ELQKSEFKMEKRDSVSSD------DGDKKHV---
torafugu_PepT1a| --QMAKLEMVKNDSQANSKP------DQT------
Atlantic_cod_PepT1a| KERKDSRRSQ-R--SSLEMT------EGTGS----D
zebrafish_PepT1a|XP_001919914.3 ---KETLEMEEKE------NEQ-----E
Japanese_eel_PepT1a|BAM67012.1 KHEMDSISPEK------K------QHDE-----E
common_carp_PepT1b|AEX13747.1 MMTKDNLAYVNNE------TSNNTD
red_crucian_carp_PepT1b|AFI42054.1 MMTKDNLAYVNNE------IN-SMD
red_crucian_x_common_carp_PepT1b|AFI42056.1 MMTKDNLAYVNNE------IN-SMD
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 MMTKDNLAYVDNE------TSNNTD
grass_carp_PepT1b|AET36827.1 SKNNETVAMAD------M
zebrafish_PepT1b|AAQ65244.1 MTAKDNMAYVHNE------NTN---
Atlantic_cod_PepT1b|AAY17354.1 ---RRSLELHDRKESLEEEN-QRKSR------SSSEASSHHEAPA
Atlantic_salmon_PepT1b|BAH24102.1 ----DQVEMERKDSDCSKSS------KGSDMK------KK--DSVVEQLNQE
southern_platyfish_PepT1b| ----KNLEMTKK-DMVENHDEKK------RRSS-N-EGK
mummichog_PepT1b|AEX92273.1 ----KNLEMTKK-DMAEKHERRS------SDTSSD-EED
spotted_green_pufferfish_PepT1b| ----KKRSLEM----VGHGNGFR------KRSDSSSSD-ETT
torafugu_PepT1b| ----KSLEMDHK-DRFGRRNEVR------ERSNSRL-D-EKN
Japanese_medaka_PepT1b| ----KSLEMAKK-ASFQHQDEDN------KSSDSSSDE-EEE
Antarctic_icefish_PepT1b|AAO39705.2 ----KSVDMSRK-SVDMSRKSVDMSRKSVDMSRKSVDMSRKSVDMSRKSSHSRSEK-DEE
three-spined_stickleback_PepT1b| ----RN---SRK-DSVEQHKEER------RSSDSSYD-NEE
European_seabass_PepT1b|ACI49693.2 ----KSLEMAKK-DSVEHHKEDR------RSS----DSS----SD-EEE
white_grouper_PepT1b|AFP33141.1 ----KSVEMKKK-DSVENRKEGR------KSS----DSSSDSSSD-EEE
yellow_perch_PepT1b|ACX49753.2 ----KSVEMTKK-DSVEHRNEDR------RSS----DSS----SD-EEE
human_PepT1|AAB61693.1 NSQKQM
chimpanzee_PepT1|XP_522705.3 NSQTQM
Rhesus_monkey_PepT1|NP_001028071.1 NSQTQM
crab-eating_macaque_PepT1|AAQ56235.1 NSQTQM
house_mouse_PepT1|NP_444309.2 VSQTNM
Norway_rat_PepT1|BAA09318.1 VSQTNM
dog_PepT1|NP_001003036.1 VSQTQM
horse_PepT1|XP_001493109.3 VSQTRM
pig_PepT1|AAO43094.1 DVQTQM
cattle_PepT1|NP_001092848.1 VSQTQM
sheep_PepT1|AAK14788.1 VSQTQM
rabbit_PepT1|AAA17721.1 VSQTQM
gray_short-tailed_opossum_PepT1|XP_001377037.2 FSQTAM
platypus_PepT1|XP_001506250.2 VAQTAL
chicken_PepT1|AAK39954.1 --VSQM
turkey_PepT1|AAO16604.1 --DSRM
western_clawed_frog_PepT1|XP_002935692.1 YSQTKM
three-spined_stickleback_PepT1a| ---TKM
China_rockfish_PepT1a|ABV82968.1 TKQSRM
Nile_tilapia_PepT1a| --QSKM
Japanese_medaka_PepT1a| M-----
mummichog_PepT1a|AEX92274.1 --KSTF
southern_platyfish_PepT1a| --QTSM
torafugu_PepT1a| ----KL
Atlantic_cod_PepT1a| PKENRM
zebrafish_PepT1a|XP_001919914.3 IKQTKI
Japanese_eel_PepT1a|BAM67012.1 MKQTKI
common_carp_PepT1b|AEX13747.1 VKQTKI
red_crucian_carp_PepT1b|AFI42054.1 VKQTKI
red_crucian_x_common_carp_PepT1b|AFI42056.1 VKQTKI
red_crucian_x_common_x_Japanese_crucian_carp_PepT1b|AFI42055.1 VKQTKI
grass_carp_PepT1b|AET36827.1 PKQTKM
zebrafish_PepT1b|AAQ65244.1 IKQTKI
Atlantic_cod_PepT1b|AAY17354.1 DKATNM
Atlantic_salmon_PepT1b|BAH24102.1 VKQSKM
southern_platyfish_PepT1b| IVQTNF
mummichog_PepT1b|AEX92273.1 GKQTNF
spotted_green_pufferfish_PepT1b| TRESKL
torafugu_PepT1b| TKETRM
Japanese_medaka_PepT1b| SKQSKM
Antarctic_icefish_PepT1b|AAO39705.2 TLQTKI
three-spined_stickleback_PepT1b| QKQTRI
European_seabass_PepT1b|ACI49693.2 TKQTKI
white_grouper_PepT1b|AFP33141.1 VKQTKI
yellow_perch_PepT1b|ACX49753.2 TPQTKI
Supplemental Figure 1. Alignment of vertebrate PEPT1 amino acid sequences. Multiple sequence alignment was obtained by Clustal Omega using default parameters. GenBank Acc. No. is indicated for the annotated sequences only. Putative transmembrane domains (1-to-12) are indicated according to Newstead et al. (2011) [Newstead S, Drew D, Cameron AD, Postis VL, Xia X, Fowler PW, Ingram, JC, Carpenter, EP, Sansom MS, McPherson MJ, Baldwin SA & Iwata S (2011). Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. EMBO J 30, 417-426] (#) and Solcan et al. (2012) [Solcan N, Kwok J, Fowler PW, Cameron AD, Drew D, Iwata S & Newstead S (2012). Alternating access mechanism in the POT family of oligopeptide transporters. EMBO J 31, 3411-3421] (%). The Thr-to-Ile substitution discussed in the manuscript (ref. position T327 in rabbit PEPT1 and I334 in zebrafish PEPT1) is boxed.