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Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia

OIE Collaborating Centre Reports

Activities in 2013

Title of Collaborating Centre: / Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Address of Collaborating Centre: / (1): National Institute of Animal Health
3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, JAPAN
(2): National Veterinary Assay Laboratory
1-15-1 Tokura, Kokubunji, Tokyo 185-8511, JAPAN
Tel.: / (1): National Institute of Animal Health
+81-42-321-1441
(2): National Veterinary Assay Laboratory
+81-42-321-1862
Fax: / (1): National Institute of Animal Health
+81-42-325-5122
(2): National Veterinary Assay Laboratory
+81-42-321-1769
e-mail address: / (1): National Institute of Animal Health

(2): National Veterinary Assay Laboratory

website: / (1): National Institute of Animal Health
http://niah.naro.affrc.go.jp/index.html
(2): National Veterinary Assay Laboratory
http://www.maff.go.jp/nval/english/
Name of Director of Institute (Responsible Official): / (1): National Institute of Animal Health
Dr Tomoyuki Tsuda, Director General
(2): National Veterinary Assay Laboratory
Dr Taketsugu Ito, Director General
Name (including Title and Position) of Head of the Collaborating Centre (formally OIE Contact Point): / Dr Kenichi Sakamoto
Director
Exotic Disease Research Division
National Institute of Animal Health
Name (including Title and Position) of writer of this report
(if different from above) / (1): National Institute of Animal Health
Dr Kazuhiro Yoshihara
Head of Planning and Promotion Section
(2): National Veterinary Assay Laboratory
Dr Shoko Iwamoto
Technical and Guidance Section Leader

Summary of activities specifically related to the mandate of
OIE Collaborating Centres

ToR: To provide services to the OIE, in particular within the region, in the designated specialty, in support of the implementation of OIE policies and, where required, seek for collaboration with OIE Reference Laboratories

ToR: To identify and maintain existing expertise, in particular within its region

1. Activities as a centre of research, expertise, standardisation and dissemination of techniques within the remit of the mandate given by the OIE

Disease control

Epidemiology, surveillance, risk assessment, modelling

Training, capacity building

Zoonoses

Wildlife

Avian diseases

Aquatic animal diseases

Animal welfare

Diagnosis, biotechnology and laboratory

Veterinary medicinal products

Vaccines

Food safety

Feed safety

Other (Name the category: Organisation of Scientific Meeting, OIE Meeting )

Disease control
Title of activity / Scope
Presentation in Symposium of Diagnostic Technique and Epidemic Control Strategies on Swine Viral Disease at Animal Health Research Institute in Taiwan, R.O.C. / Dr H. Tsunemitsu, Dr T. Kokuho and Dr M. Takagi were invited as speakers and made presentations entitled Laboratory and research support on the eradication of classical swine fever in Japan (Dr Takagi) and Molecular epidemiology and diagnosis of porcine reproductive and respiratory syndrome in Japan (Dr Takagi), Molecular epidemiology of porcine viral diarrhea: porcine epidemic diarrhea in Asia and the U.S. (Dr Tsunemitsu), Epidemic situation, and control policy of swine viral diseases in Japan (Dr Kokuho).
Attendance at the 8th SEACFMD Laboratory Network Meeting on Nov 12th and 13th in Thailand / Dr K. Sakamoto attended the 8th SEACFMD Laboratory Network Meeting as a FMD expert.
Dispatch to Myanmar as an expert of FMD to exchange opinions about the technical cooperation for FMD control / Dr T. Kanno joined the investigating group of the Ministry of Agriculture, Forestry and Fisheries in Japan to exchange opinions about the technical cooperation for FMD control in Myanmar.
Discussion with National Institute of Animal Health in Thailand about PRRS and CSF / Dr T. Kawashima and Dr T. Takagi visited NIAH in Thailand to discuss a study on PRRS and CSF.
Presentation in First International Workshop on Streptococcus suis, Canada-China Collaboration, in China. / Dr D. Takamatsu was invited as a speaker and made a presentation entitled Diversity and Universality of Streptococcus suis cps Gene Clusters.
Epidemiology, surveillance, risk assessment, modelling
Title of activity / Scope
Presentation at International Symposium of Korean Society of Veterinary Science and at Internal workshop of Veterinary Epidemiology / Dr T. Tsutsui was invited as a speaker and made presentations entitled Epidemiology of foot-and-mouth disease in Japan at the symposium and the workshop in Korea.
The review at the middle of the term of JICA Project on Capacity Development of the Animal Health Laboratory in Indonesia / Dr T. Yamamoto reviewed the field of epidemiology of the JICA project in Indonesia.
Investigation into the titer of antibody to FMD virus in Laos / Dr K. Sakamoto, Dr K. Fukai and Dr K. Morioka carried out a field surveillance for the titer of antibody to FMD virus from cattle inoculated FMD vaccine in Laos.
Training, capacity building
Title of activity / Scope
Dispatch as an expert of FMD to Myanmar to conduct Identification Survey for The Project for Improvement of FMD Control in Myanmar / Dr K. Sakamoto joined the investigating group to conduct preliminary survey for JICA's new project aiming at vaccine production in Myanmar as an expert of FMD.
JICA Project on Capacity Development of Animal Health Laboratory in Indonesia / Dr T. Shibahara was sent to Balai Veteriner Subang in Indonesia as a JICA expert of pathology for two months to contribute toward JICA Project on Capacity Development of Animal Health Laboratory in Indonesia
Zoonoses
Title of activity / Scope
Monitoring of antimicrobial resistant bacteria from environmental origin / More than 500 Enterobacteriaceae were isolated from environmental water samples collected in India and Sri Lanka in 2013 and investigated their antimicrobial susceptibilities to chech the environmental contamination by resistant bacteria. (Dr M. Akiba and Dr Guruge Keerthi Siri)
Veterinary medicinal products, vaccines
Title of activity / Scope
Quality Control activities for veterinary medicinal products and vaccines / A total of 5 veterinary medicinal products were tested on request from manufacturing authorization holder and 391 biologics were received the national assay in 2013.
Approval Activities for veterinary medicinal products and vaccines / A total of 38 antibiotics (including 4 in vitro diagnostics for antibiotics), 31 biologics (including 4 in vitro diagnostics for biologics) and 40 other VMPs (including 1 in vitro diagnostic) were approved in 2013.
Other: Organisation of Scientific Meeting
Title of activity / Scope
Holding the Second Joint Meeting of NIAH Japan and NIAH Thailand / Based of the MOU on strengthening research cooperation in the fields of mutual interest on veterinary science with National Institute of Animal Health in Thailand, the scientific meeting was held in NIAH, Tsukuba, Japan to exchange information and talk about possibility of research cooperation. The third meeting will be held in Thailand in 2014.
Other: OIE Meeting
Title of activity / Scope
Attendance at Terrestrial Animal Health Standards Commission (the Code Commission) on Sep 17-26 in France / Dr T. Tustsui who is a member of the code commission was invited the Code Commission by OIE.
Attendance at Technical meeting of OIE experts on Schumallengerg virus on May 7-8 in France. / Dr Tsutsui was invited to Technical meeting of OIE experts on Schumallengerg virus.
Attendance at FMD Scientific Meeting for East Asia under OIE/JTF Project for FMD Control in Asia on Oct 8th in Mongolia / Dr K. Sakamoto was invited to FMD Scientific Meeting for East Asia under OIE/JTF Project for FMD Control in Asia as a chairman.
Dr M. Yamada and Dr K. Fukai were invited for speakers to the meeting by OIE. Titles: Characters of FMD DIVA tests and Verification of Efficacy of Expired FMD O Type Vaccines (Dr Yamada), Experimental infections in animals using a foot-and-mouth disease virus isolated from the 2010 epidemic in Japan (Dr Fukai)
Attendance at 2nd National Contact Person Workshop and 2nd Coordination Committee Meetin under OIE/JTF Project on FMD Control in Asia on Oct 6th and 7th in Mongolia / Dr K. Sakamoto was invited to 2nd National Contact Person Workshop and 2nd Coordination Committee Meetin under OIE/JTF Project on FMD Control in Asia by OIE.
Attendance at the Meeting of the OIE Terrestrial Animal Health Standards Commission as a member of the code commission on Feb 19-28 in Paris / Dr T. Tsutsui who is a member of the code commission attended the Meeting of the OIE Terrestrial Animal Health Standards Commission as a member of the code commission.
Attendance at the South-East Asian countries and China discuss foot and mouth disease control on Mar. 19 in Singapore / Dr K. Sakamoto was invited the OIE Meeting, South-East Asian countries and China discuss foot and mouth disease control by OIE.
Attendance at 28th Conference of the OIE Regional Commission for Asia on Nov. 18-22 in Philippines / Dr T. Tsutsui was invited 28th Conference of the OIE Regional Commission for Asia and presented at Regional Seminar for OIE Delegates on Activities of Specialist Commissions entiteld "Principle and Procedures of OIE standard Setting" as a member of the code commission.

ToR: To propose or develop methods and procedures that facilitate harmonisation of international standards and guidelines applicable to the designated specialty

2. Proposal or development of any procedure that will facilitate harmonisation of international regulations applicable to the surveillance and control of animal diseases, food safety or animal welfare

Proposal title / Scope/Content / Applicable area /
Development of the VICH guidelines (GLs) concerning to studies to evaluate the quality of veterinary drugs. / -To develop the new VICH GL 51(statistical evaluation of stability data) / Surveillance and control of animal diseases
Food safety
Animal welfare
Development of the VICH guidelines (GLs) concerning to pharmacovigilance of veterinary drugs. / -To develop the new VICH GL 35 (electronic standards for transfer of data ) / Surveillance and control of animal diseases
Food safety
Animal welfare
Development of the VICH guidelines (GLs) concerning to veterinary biological quality monitoring. / -To develop the new VICH GL 34 (test for the detection of Mycoplasma contamination )
-To develop the new VICH GL (test on the presence of extraneous viruses in veterinary viral vaccines ) / Surveillance and control of animal diseases
Food safety
Animal welfare
Development of VICH harmonisation criteria to waive target animal batch safety testing for vaccines for veterinary use. / -To develop the VICH GL50 (for inactivated vaccines)
-To develop the new VICH GL (for live vaccines) / Surveillance and control of animal diseases
Food safety
Animal welfare
Development or revision of the VICH guidelines (GLs) concerning to studies to evaluate the metabolism and residue kinetics of veterinary drugs in food-producing animals. / -To revise the VICH GL48 (marker residue depletion studies to establish product withdrawal periods)
-To develop the new VICH GL (marker residue depletion studies to establish product withdrawal periods in aquatic species)
-To develop the new VICH GL (residue studies in honey) / Surveillance and control of animal diseases
Food safety
Animal welfare
Development or revision of the VICH guidelines (GLs) concerning to studies to evaluate the safety of residues of veterinary drugs in human food. / -To revise the VICH GL 23R (genotoxicity testing)
-To develop the new VICH GL (use of the acute reference dose for veterinary drugs) / Surveillance and control of animal diseases
Food safety
Animal welfare
Development of the VICH guidelines (GLs) concerning to bioequivalance of veterinary drugs. / -To develop the new VICH GL 52 (blood level bioequivalence study ) / Surveillance and control of animal diseases
Food safety
Animal welfare
Development of the VICH guidelines (GLs) concerning to electronic exchange of documents. / -To develop the new VICH GL 53 (file format requirements ) / Surveillance and control of animal diseases
Food safety
Animal welfare

ToR: To establish and maintain a network with other OIE Collaborating Centres designated for the same specialty, and should the need arise, with Collaborating Centres in other disciplines

ToR: To carry out and/or coordinate scientific and technical studies in collaboration with other centres, laboratories or organisations

3. Did your Collaborating Centre maintain a network with other OIE Collaborating Centres (CC), Reference Laboratories (RL), or organisations designated for the same specialty, to coordinate scientific and technical studies?

Yes No

Name of OIE CC/RL/other organisation(s) / Location / Region of networking Centre / Purpose /
Animal and Plant Quarantine Agency / Korea / Africa
Americas
Asia and Pacific
Europe
Middle East / General MOU on promoting research cooperation in the fields of mutual interest such as surveillance, diagnosis and control of major animal diseases
National Institute of Animal Health / Thailand / Africa
Americas
Asia and Pacific
Europe
Middle East / General MOU on strengthening research cooperation in the fields of mutual interest on veterinary science
Department of Livestock Development / Thaiand / Africa
Americas
Asia and Pacific
Europe
Middle East / MOU on a collaboration project entitled “Epidemiological Research Collaboration on Avian Influenza and Zoonotic Diseases in Thailand and Neighbouring Countries”
Mahidol University / Thailand / Africa
Americas
Asia and Pacific
Europe
Middle East / MOU on a collaboration project entitled “Epidemiological and pathogenicity researches on avian influenza, arbovirus infection and porcine respiratory diseases etc”
ANSES, FDA-CVM / EU, USA, Japan / Africa
Americas
Asia and Pacific
Europe
Middle East / To prepare for the VICH Outreach Forum that is held every 9 month back to back with the VICH Steering Committee (SC). The VICH Outreach Subgroup consists of VICH-SC member and OIE Collaborating Centres work together to establish a program and to nominate speakers and a chair of the forum meeting. The Training Strategy ad hoc working group also consists of VICH-SC member and OIE Collaborating Centres work to design overall training strategy for VMP authority in member countries.
Asian veterinary medicinal products regulatory authorities / China, Hong Kong, Indonesia, Korea ,Philippines, Taiwan, Thailand and Japan / Africa
Americas
Asia and Pacific
Europe
Middle East / In order to reduce information gap among the members in Asian region, a mail news called "AVAIL*news" is sent on irregular basis (7 issues in 2013) to Asian VMP regulatory authorities (Codex Committee-Asia members and VICH Outreach Forum members of interest).
*AVAIL: Asian VMP Authority
Information Link is an informal communication among Asian Veterinary Medicinal Product-Authorities

4. Did your Collaborating Centre maintain a network with other OIE Collaborating Centres, Reference laboratories, or organisations in other disciplines, to coordinate scientific and technical studies?