FOOTPRINTS of GENERAL SYSTEMS THEORY Aleksandar Malecic Faculty of Electronic Engineering University of Nis, Serbia Aleks.Maleci
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COMPLEX SYSTEMS BIOLOGY and HEGEL's PHILOSOPHY Kazuyuki
COMPLEX SYSTEMS BIOLOGY AND HEGEL’S PHILOSOPHY Kazuyuki Ikko Takahashi KandaSurugadai 1-1, Chiyoda, Tokyo 101-8301, Meiji University ABSTRACT In this study I will argue that Hegel’s philosophy has similarity to the self- organization theories of Prigogine and Kauffman and complex systems biology of Kaneko, and is therefore an idea in advance of its times. In The Philosophy of Nature, Hegel’s interest is in how nature evolves through the mechanism of self-organization. He was writing before Darwin proposed the theory of evolution, and his dialectic is aimed at analyzing and describing development in the logical sense. The important feature of this work is their analysis of the fundamental structures by which order is generated. Hegel struggled to produce the concept of life from that of matter. He proposed that matter should develop into organism, but only in a logical sense. Nature itself is a system of producing spontaneous order through the random motion of the contingent. Then Hegel tackles living things. He would like to say that the basis of life is the non-equilibrium self-referential structure. In more modern terminology, we could interpret this as meaning that the first organism emerged from interaction between high polymers. Living creatures exhibit flexibility and plasticity through fluctuations in these elements. Complex systems biology uses a dynamical systems approach to explain how living things acquire diversity, stability and spontaneity. First, simple single-celled organisms arose through interactions between proteins and nucleic acids. These are the archae-bacteria in modern terminology. Next, the development of eukaryote cells from the prokaryotes is explained by symbiogenesis or endosymbiotic theory. -
Quantum Biology: an Update and Perspective
quantum reports Review Quantum Biology: An Update and Perspective Youngchan Kim 1,2,3 , Federico Bertagna 1,4, Edeline M. D’Souza 1,2, Derren J. Heyes 5 , Linus O. Johannissen 5 , Eveliny T. Nery 1,2 , Antonio Pantelias 1,2 , Alejandro Sanchez-Pedreño Jimenez 1,2 , Louie Slocombe 1,6 , Michael G. Spencer 1,3 , Jim Al-Khalili 1,6 , Gregory S. Engel 7 , Sam Hay 5 , Suzanne M. Hingley-Wilson 2, Kamalan Jeevaratnam 4, Alex R. Jones 8 , Daniel R. Kattnig 9 , Rebecca Lewis 4 , Marco Sacchi 10 , Nigel S. Scrutton 5 , S. Ravi P. Silva 3 and Johnjoe McFadden 1,2,* 1 Leverhulme Quantum Biology Doctoral Training Centre, University of Surrey, Guildford GU2 7XH, UK; [email protected] (Y.K.); [email protected] (F.B.); e.d’[email protected] (E.M.D.); [email protected] (E.T.N.); [email protected] (A.P.); [email protected] (A.S.-P.J.); [email protected] (L.S.); [email protected] (M.G.S.); [email protected] (J.A.-K.) 2 Department of Microbial and Cellular Sciences, School of Bioscience and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; [email protected] 3 Advanced Technology Institute, University of Surrey, Guildford GU2 7XH, UK; [email protected] 4 School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; [email protected] (K.J.); [email protected] (R.L.) 5 Manchester Institute of Biotechnology, Department of Chemistry, The University of Manchester, -
An Information-Theoretic Metric of System Complexity with Application
An Information-Theoretic Metric Douglas Allaire1 of System Complexity With e-mail: [email protected] Application to Engineering Qinxian He John Deyst System Design Karen Willcox System complexity is considered a key driver of the inability of current system design practices to at times not recognize performance, cost, and schedule risks as they emerge. Aerospace Computational Design Laboratory, We present here a definition of system complexity and a quantitative metric for measuring Department of Aeronautics and Astronautics, that complexity based on information theory. We also derive sensitivity indices that indi- Massachusetts Institute of Technology, cate the fraction of complexity that can be reduced if more about certain factors of a sys- Cambridge, MA 02139 tem can become known. This information can be used as part of a resource allocation procedure aimed at reducing system complexity. Our methods incorporate Gaussian pro- cess emulators of expensive computer simulation models and account for both model inadequacy and code uncertainty. We demonstrate our methodology on a candidate design of an infantry fighting vehicle. [DOI: 10.1115/1.4007587] 1 Introduction methodology identifies the key contributors to system complexity and provides quantitative guidance for resource allocation deci- Over the years, engineering systems have become increasingly sions aimed at reducing system complexity. complex, with astronomical growth in the number of components We define system complexity as the potential for a system to and their interactions. With this rise in complexity comes a host exhibit unexpected behavior in the quantities of interest. A back- of new challenges, such as the adequacy of mathematical models ground discussion on complexity metrics, uncertainty sources in to predict system behavior, the expense and time to conduct complex systems, and related work presented in Sec. -
The BRAIN in Space a Teacher’S Guide with Activities for Neuroscience This Page Intentionally Left Blank
Educational Product National Aeronautics and Teachers Grades 5–12 Space Administration The BRAIN in Space A Teacher’s Guide With Activities for Neuroscience This page intentionally left blank. The Brain in Space A Teacher’s Guide With Activities for Neuroscience National Aeronautics and Space Administration Life Sciences Division Washington, DC This publication is in the Public Domain and is not protected by copyright. Permission is not required for duplication. EG-1998-03-118-HQ This page intentionally left blank. This publication was made possible by the National Acknowledgments Aeronautics and Space Administration, Cooperative Agreement No. NCC 2-936. Principal Investigator: Walter W.Sullivan, Jr., Ph.D. Neurolab Education Program Office of Operations and Planning Morehouse School of Medicine Atlanta, GA Writers: Marlene Y. MacLeish, Ed.D. Director, Neurolab Education Program Morehouse School of Medicine Atlanta, GA Bernice R. McLean, M.Ed. Deputy Director, Neurolab Education Program Morehouse School of Medicine Atlanta, GA Graphic Designer and Illustrator: Denise M.Trahan, B.A. Atlanta, GA Technical Director: Perry D. Riggins Neurolab Education Program Morehouse School of Medicine Atlanta, GA This page intentionally left blank. Contributors This publication was developed for the National Aeronautics and Space Administration (NASA) under a Cooperative Agreement with the Morehouse School of Medicine (MSM). Many individu- als and organizations contributed to the production of this curriculum. We acknowledge their support and contributions. Organizations: Joseph Whittaker, Ph.D. Atlanta Public School System Neurolab Education Program Advisory Board: Society for Neuroscience Gene Brandt The Dana Alliance for Brain Initiatives Milton C. Clipper, Jr. Mary Anne Frey, Ph.D. NASA Headquarters: Charles A. -
Complex Systems Analysis of Arrested Neural Cell Differentiation During Development and Analogous Cell Cycling Models in Carcinogenesis
[04-01-2012 Preprint Update] Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis V. I. Prisecaru and I.C. Baianu AFC-NMR & NIR Microspectroscopy Facility, College of ACES, FSHN & NPRE Departments, University of Illinois at Urbana, Urbana, IL. 61801, USA Email address: ibaianu @illinois.edu 1.Introduction A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell cycling network transformations involved in carcinogenesis is proposed. Neural tissue arrested differentiation that induces cell proliferation during perturbed development and Carcinogenesis are complex processes that involve dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments. Such 'dynamically inter-connected' biomolecules form numerous inter- related pathways referred to as 'molecular networks'. One such family of signaling pathways contains Nature Precedings : hdl:10101/npre.2012.7101.2 Posted 2 Apr 2012 the cell cyclins. Cyclins are proteins that link several critical pro-apoptotic and other cell cycling/division components, including the tumor suppressor gene TP53 and its product, the Thomsen-Friedenreich antigen (T antigen), Rb, mdm2, c-Myc, p21, p27, Bax, Bad and Bcl-2, which play major roles in various neoplastic transformations of many tissues. 1. Arrested Cell Differentiation in Neural -
Introduction to Cyber-Physical System Security: a Cross-Layer Perspective
IEEE TRANSACTIONS ON MULTI-SCALE COMPUTING SYSTEMS, VOL. 3, NO. 3, JULY-SEPTEMBER 2017 215 Introduction to Cyber-Physical System Security: A Cross-Layer Perspective Jacob Wurm, Yier Jin, Member, IEEE, Yang Liu, Shiyan Hu, Senior Member, IEEE, Kenneth Heffner, Fahim Rahman, and Mark Tehranipoor, Senior Member, IEEE Abstract—Cyber-physical systems (CPS) comprise the backbone of national critical infrastructures such as power grids, transportation systems, home automation systems, etc. Because cyber-physical systems are widely used in these applications, the security considerations of these systems should be of very high importance. Compromise of these systems in critical infrastructure will cause catastrophic consequences. In this paper, we will investigate the security vulnerabilities of currently deployed/implemented cyber-physical systems. Our analysis will be from a cross-layer perspective, ranging from full cyber-physical systems to the underlying hardware platforms. In addition, security solutions are introduced to aid the implementation of security countermeasures into cyber-physical systems by manufacturers. Through these solutions, we hope to alter the mindset of considering security as an afterthought in CPS development procedures. Index Terms—Cyber-physical system, hardware security, vulnerability Ç 1INTRODUCTION ESEARCH relating to cyber-physical systems (CPS) has In addition to security concerns, CPS privacy is another Rrecently drawn the attention of those in academia, serious issue. Cyber-physical systems are often distributed industry, and the government because of the wide impact across wide geographic areas and typically collect huge CPS have on society, the economy, and the environment [1]. amounts of information used for data analysis and decision Though still lacking a formal definition, cyber-physical making. -
Restricted Agents in Thermodynamics and Quantum Information Theory
Research Collection Doctoral Thesis Restricted agents in thermodynamics and quantum information theory Author(s): Krämer Gabriel, Lea Philomena Publication Date: 2016 Permanent Link: https://doi.org/10.3929/ethz-a-010858172 Rights / License: In Copyright - Non-Commercial Use Permitted This page was generated automatically upon download from the ETH Zurich Research Collection. For more information please consult the Terms of use. ETH Library Diss. ETH No. 23972 Restricted agents in thermodynamics and quantum information theory A thesis submitted to attain the degree of DOCTOR OF SCIENCES of ETH ZURICH (Dr. sc. ETH Zurich) presented by Lea Philomena Kr¨amer Gabriel MPhysPhil, University of Oxford born on 18th July 1990 citizen of Germany accepted on the recommendation of Renato Renner, examiner Giulio Chiribella, co-examiner Jakob Yngvason, co-examiner 2016 To my family Acknowledgements First and foremost, I would like to thank my thesis supervisor, Prof. Renato Renner, for placing his trust in me from the beginning, and giving me the opportunity to work in his group. I am grateful for his continuous support and guidance, and I have always benefited greatly from the discussions we had | Renato without doubt has a clear vision, a powerful intuition, and a deep understanding of physics and information theory. Perhaps even more importantly, he has an exceptional gift for explaining complex subjects in a simple and understandable way. I would also like to thank my co-examiners Giulio Chiribella and Jakob Yngvason for agreeing to be part of my thesis committee, and for their input and critical questions in the discussions and conversations we had. -
Cyber-Physical Systems, a New Formal Paradigm to Model Redundancy and Resiliency Mario Lezoche, Hervé Panetto
Cyber-Physical Systems, a new formal paradigm to model redundancy and resiliency Mario Lezoche, Hervé Panetto To cite this version: Mario Lezoche, Hervé Panetto. Cyber-Physical Systems, a new formal paradigm to model redun- dancy and resiliency. Enterprise Information Systems, Taylor & Francis, 2020, 14 (8), pp.1150-1171. 10.1080/17517575.2018.1536807. hal-01895093 HAL Id: hal-01895093 https://hal.archives-ouvertes.fr/hal-01895093 Submitted on 13 Oct 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Cyber-Physical Systems, a new formal paradigm to model redundancy and resiliency Mario Lezoche, Hervé Panetto Research Centre for Automatic Control of Nancy (CRAN), CNRS, Université de Lorraine, UMR 7039, Boulevard des Aiguillettes B.P.70239, 54506 Vandoeuvre-lès-Nancy, France. e-mail: {mario.lezoche, herve.panetto}@univ-lorraine.fr Cyber-Physical Systems (CPS) are systems composed by a physical component that is controlled or monitored by a cyber-component, a computer-based algorithm. Advances in CPS technologies and science are enabling capability, adaptability, scalability, resiliency, safety, security, and usability that will far exceed the simple embedded systems of today. CPS technologies are transforming the way people interact with engineered systems. -
Loop Quantum Gravity: the First 25 Years Carlo Rovelli
Loop quantum gravity: the first 25 years Carlo Rovelli To cite this version: Carlo Rovelli. Loop quantum gravity: the first 25 years. Classical and Quantum Gravity, IOP Publishing, 2011, 28 (15), pp.153002. 10.1088/0264-9381/28/15/153002. hal-00723006 HAL Id: hal-00723006 https://hal.archives-ouvertes.fr/hal-00723006 Submitted on 7 Aug 2012 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Loop quantum gravity: the first twenty five years Carlo Rovelli Centre de Physique Th´eorique de Luminy∗, Case 907, F-13288 Marseille, EU (Dated: January 27, 2011) I give a synthetic presentation of loop quantum gravity. I spell-out the aims of the theory and compare the results obtained with the initial hopes that motivated the early interest in this research direction. I give my own perspective on the status of the program and attempt of a critical evaluation of its successes and limits. I. INTRODUCTION The history of quantum gravity is full of great hopes later disappointed. I remember as a young student sitting in a major conference where a world-renowned physicists Loop gravity is not quite twenty-five years old, but announced that the final theory of quantum gravity and is getting close to such a venerable age: several basic everything had finally been found. -
Systems Biology 1 Systems Biology
Systems biology 1 Systems biology Systems biology is a term used to describe a number of trends in bioscience research, and a movement which draws on those trends. Proponents describe systems biology as a biology-based inter-disciplinary study field that focuses on complex interactions in biological systems, claiming that it uses a new perspective (holism instead of reduction). Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. An often stated ambition of An attempted illustration of the systems approach to biology systems biology is the modeling and discovery of emergent properties, properties of a system whose theoretical description is only possible using techniques which fall under the remit of systems biology. These typically involve cell signaling networks, via long-range allostery[1]. Overview Systems biology can be considered from a number of different aspects: • As a field of study, particularly, the study of the interactions between the components of biological systems, and how these interactions give rise to the function and behavior of that system (for example, the enzymes and metabolites in a metabolic pathway).[2][3] • As a paradigm, usually defined in antithesis to the so-called reductionist paradigm (biological organisation), although fully consistent with the scientific method. The distinction between the two paradigms is referred to in these quotations: "The reductionist approach has successfully identified most of the components and many of the interactions but, unfortunately, offers no convincing concepts or methods to understand how system properties emerge...the pluralism of causes and effects in biological networks is better addressed by observing, through quantitative measures, multiple components simultaneously and by rigorous data integration with mathematical models" Sauer et al[4] "Systems biology...is about putting together rather than taking apart, integration rather than reduction. -
Calculating Space) 1St
Konrad Zuse’s Rechnender Raum (Calculating Space) 1st. re-edition1 written in LATEX by A. German and H. Zenil As published in A Computable Universe: Understanding & Exploring Nature as Computation, World Scientific, 2012 Painting by Konrad Zuse (under the pseudonym “Kuno See”). Followed by an Afterword by Adrian German and Hector Zenil 2 1with kind permission by all parties involved, including MIT and Zuse’s family. 2The views expressed in the afterword do not represent the views of those organisations with which the authors are affiliated. 1 Calculating Space (“Rechnender Raum”)z Konrad Zuse Contents 1 INTRODUCTION 1 2 INTRODUCTORY OBSERVATIONS 3 2.1 Concerning the Theory of Automatons . .3 2.2 About Computers . .5 2.3 Differential Equations from the Point of View of the Automa- ton Theory . .8 2.4 Maxwell Equations . 10 2.5 An Idea about Gravitation . 13 2.6 Differential Equations and Difference Equations, Digitalization 13 2.7 Automaton Theory Observations of Physical Theories . 14 3 EXAMPLES OF DIGITAL TREATMENT OF FIELDS AND PARTICLES 19 3.1 The Expression “Digital Particle” . 19 3.2 Two-Dimensional Systems . 27 3.3 Digital Particles in Two-Dimensional Space . 30 3.4 Concerning Three-Dimensional Systems . 34 4 GENERAL CONSIDERATIONS 37 4.1 Cellular Automatons . 37 4.2 Digital Particles and Cellular Automatons . 39 4.3 On the Theory of Relativity . 39 zSchriften zur Datenverarbeitung, Vol. 1, 1969 Friedrich Vieweg & Sohn, Braun- schweig, 74 pp. MIT Technical TranslationTranslated for Massachusetts Institute of Tech- nology, Project MAC, by: Aztec School of Languages, Inc., Research Translation Division (164), Maynard, Massachusetts and McLean, Virginia AZT-70-164-GEMIT Massachusetts Institute of Technology, Project MAC, Cambridge, Massachusetts 02139—February 1970 2 4.4 Considerations of Information Theory . -
Quantum Mechanics Digital Physics
Quantum Mechanics_digital physics In physics and cosmology, digital physics is a collection of theoretical perspectives based on the premise that the universe is, at heart, describable byinformation, and is therefore computable. Therefore, according to this theory, the universe can be conceived of as either the output of a deterministic or probabilistic computer program, a vast, digital computation device, or mathematically isomorphic to such a device. Digital physics is grounded in one or more of the following hypotheses; listed in order of decreasing strength. The universe, or reality: is essentially informational (although not every informational ontology needs to be digital) is essentially computable (the pancomputationalist position) can be described digitally is in essence digital is itself a computer (pancomputationalism) is the output of a simulated reality exercise History Every computer must be compatible with the principles of information theory,statistical thermodynamics, and quantum mechanics. A fundamental link among these fields was proposed by Edwin Jaynes in two seminal 1957 papers.[1]Moreover, Jaynes elaborated an interpretation of probability theory as generalized Aristotelian logic, a view very convenient for linking fundamental physics withdigital computers, because these are designed to implement the operations ofclassical logic and, equivalently, of Boolean algebra.[2] The hypothesis that the universe is a digital computer was pioneered by Konrad Zuse in his book Rechnender Raum (translated into English as Calculating Space). The term digital physics was first employed by Edward Fredkin, who later came to prefer the term digital philosophy.[3] Others who have modeled the universe as a giant computer include Stephen Wolfram,[4] Juergen Schmidhuber,[5] and Nobel laureate Gerard 't Hooft.[6] These authors hold that the apparentlyprobabilistic nature of quantum physics is not necessarily incompatible with the notion of computability.