History of Genetics
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Intelligent Design, Abiogenesis, and Learning from History: Dennis R
Author Exchange Intelligent Design, Abiogenesis, and Learning from History: Dennis R. Venema A Reply to Meyer Dennis R. Venema Weizsäcker’s book The World View of Physics is still keeping me very busy. It has again brought home to me quite clearly how wrong it is to use God as a stop-gap for the incompleteness of our knowledge. If in fact the frontiers of knowledge are being pushed back (and that is bound to be the case), then God is being pushed back with them, and is therefore continually in retreat. We are to find God in what we know, not in what we don’t know; God wants us to realize his presence, not in unsolved problems but in those that are solved. Dietrich Bonhoeffer1 am thankful for this opportunity to nature, is the result of intelligence. More- reply to Stephen Meyer’s criticisms over, this assertion is proffered as the I 2 of my review of his book Signature logical basis for inferring design for the in the Cell (hereafter Signature). Meyer’s origin of biological information: if infor- critiques of my review fall into two gen- mation only ever arises from intelli- eral categories. First, he claims I mistook gence, then the mere presence of Signature for an argument against bio- information demonstrates design. A few logical evolution, rendering several of examples from Signature make the point my arguments superfluous. Secondly, easily: Meyer asserts that I have failed to refute … historical scientists can show that his thesis by not providing a “causally a presently acting cause must have adequate alternative explanation” for the been present in the past because the origin of life in that the few relevant cri- proposed candidate is the only known tiques I do provide are “deeply flawed.” cause of the effect in question. -
MOLECULAR GENETICIST UBC's Centre for Applied Neurogenetics, Within the Faculty of Medicine, Division of Neurology and Departm
MOLECULAR GENETICIST UBC’s Centre for Applied Neurogenetics, within the Faculty of Medicine, Division of Neurology and Department of Medical Genetics, is seeking a talented and highly motivated Postdoctoral Fellow/Research scientist with a strong background in human genetics. The post- holder will join a multi-discipline team and contribute significantly to identify genetic variability that either causes or contributes to the onset of neurologic and neurodegenerative disease. His/her role will involve working closely with bioinformatician, scientific and medical staff to elucidate the genetic architecture of these diseases (particularly Parkinson’s disease) using state- of-the-art approaches, which range from classical linkage, genome-wide genotyping, through next-generation sequencing, mainly exome and other targeted sequencing experiments (Farrer M. Nat. Rev. Genet. 2006; Farrer M. et al., Nat. Genet. 2008; Vilarino-Guell C. et al., Am. J. Hum. Genet. 2011). Results are used for diagnostic and therapeutic development in partnership with other academic groups and the Pharmaceutical industry (Lewis J. et al., Mol. Neurodegeneration 2008; Melrose H et al., Neurobio Dis. 2010). He/she may also participate in the supervision of interns and graduate students, as well as grant writing. The successful candidate will hold a Ph.D. specializing in human molecular genetics, with an aptitude for molecular biology, statistical genetics and/or bioinformatics. Must have experience with Sanger sequencing, Sequenom, TaqMan and microsatellite genotyping, and strong interest in NGS applied to human disease is desired. He/she will have demonstrated research acumen and have a track record of successful publications, ideally in neurologic and/or neurodegenerative disease. For its beauty and amenities Vancouver is consistently ranked within the top 5 cities to live in the world. -
Genetics and Other Human Modification Technologies: Sensible International Regulation Or a New Kind of Arms Race?
GENETICS AND OTHER HUMAN MODIFICATION TECHNOLOGIES: SENSIBLE INTERNATIONAL REGULATION OR A NEW KIND OF ARMS RACE? HEARING BEFORE THE SUBCOMMITTEE ON TERRORISM, NONPROLIFERATION, AND TRADE OF THE COMMITTEE ON FOREIGN AFFAIRS HOUSE OF REPRESENTATIVES ONE HUNDRED TENTH CONGRESS SECOND SESSION JUNE 19, 2008 Serial No. 110–201 Printed for the use of the Committee on Foreign Affairs ( Available via the World Wide Web: http://www.foreignaffairs.house.gov/ U.S. GOVERNMENT PRINTING OFFICE 43–068PDF WASHINGTON : 2008 For sale by the Superintendent of Documents, U.S. Government Printing Office Internet: bookstore.gpo.gov Phone: toll free (866) 512–1800; DC area (202) 512–1800 Fax: (202) 512–2104 Mail: Stop IDCC, Washington, DC 20402–0001 COMMITTEE ON FOREIGN AFFAIRS HOWARD L. BERMAN, California, Chairman GARY L. ACKERMAN, New York ILEANA ROS-LEHTINEN, Florida ENI F.H. FALEOMAVAEGA, American CHRISTOPHER H. SMITH, New Jersey Samoa DAN BURTON, Indiana DONALD M. PAYNE, New Jersey ELTON GALLEGLY, California BRAD SHERMAN, California DANA ROHRABACHER, California ROBERT WEXLER, Florida DONALD A. MANZULLO, Illinois ELIOT L. ENGEL, New York EDWARD R. ROYCE, California BILL DELAHUNT, Massachusetts STEVE CHABOT, Ohio GREGORY W. MEEKS, New York THOMAS G. TANCREDO, Colorado DIANE E. WATSON, California RON PAUL, Texas ADAM SMITH, Washington JEFF FLAKE, Arizona RUSS CARNAHAN, Missouri MIKE PENCE, Indiana JOHN S. TANNER, Tennessee JOE WILSON, South Carolina GENE GREEN, Texas JOHN BOOZMAN, Arkansas LYNN C. WOOLSEY, California J. GRESHAM BARRETT, South Carolina SHEILA JACKSON LEE, Texas CONNIE MACK, Florida RUBE´ N HINOJOSA, Texas JEFF FORTENBERRY, Nebraska JOSEPH CROWLEY, New York MICHAEL T. MCCAUL, Texas DAVID WU, Oregon TED POE, Texas BRAD MILLER, North Carolina BOB INGLIS, South Carolina LINDA T. -
The Early History of Medical Genetics in Canada William Leeming OCAD University [email protected]
OCAD University Open Research Repository Faculty of Liberal Arts & Sciences and School of Interdisciplinary Studies 2004 The Early History of Medical Genetics in Canada William Leeming OCAD University [email protected] © Oxford University Press. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. Original source at DOI: 10.1093/shm/17.3.481. Recommended citation: Leeming, W. “The Early History of Medical Genetics in Canada.” Social History of Medicine 17.3 (2004): 481–500. Web. Leeming, W. (2004). The early history of medical genetics in Canada. Social History of Medicine, 17(3), 481-500. Pre-Publication Draft The Early History of Medical Genetics in Canada Abstract: This article shows that the intellectual and specialist movements that supported the growth of medical genetics in Canada between 1947 and 1990 were emergent phenomena, created, split, and reattached to different groups of actors, and reconfigured numerous times over the course of four decades. In each instance, new kinds of working relationships appeared; sets of diverse actors in local university- hospital settings coalesced into a new collectivity; and, as a collectivity, actors defined and/or redefined occupational roles and work rules. In its beginnings, medical genetics appears to be the object of a serious institutional manoeuver: a movement in support of the creation of examining and teaching positions in human genetics in North American medical schools. With time, the institutionalization of ‘medical genetics’ took hold, spurred on by changes in the rate and direction of service delivery associated with genetic consultation and laboratory services in clinical settings. -
Genetics, Epigenetics and Disease a Literature Review By: Anthony M
Genetics, Epigenetics and Disease A Literature Review By: Anthony M. Pasek Faculty Advisor: Rodger Tepe, PhD A senior research project submitted in partial requirement for the degree Doctor of Chiropractic August 11, 2011 Abstract Objective – This article provides an overview of the scientific literature available on the subject of genetic mechanisms of disease etiology as compared to epigenetic mechanisms of disease etiology. The effects of environmental influences on genetic expression and transgenerational inheritance will also be examined. Methods – Searches of the keywords listed below in the databases PubMed and EBSCO Host yielded referenced articles from indexed journals, literature reviews, pilot studies, longitudinal studies, and conference meeting reports. Conclusion – Although current research trends indicate a relationship between the static genome and the dynamic environment and offer epigenetics as a mechanism, further research is necessary. Epigenetic processes have been implicated in many diseases including diabetes mellitus, obesity, cardiovascular disease, metabolic disease, cancer, autism, Alzheimer’s disease, depression, and addiction. Keywords – genetics, central dogma of biology, genotype, phenotype, genomic imprinting, epigenetics, histone modification, DNA methylation, agouti mice, epigenetic drift, Överkalix, Avon Longitudinal Study of Parents and Children (ALSPAC). 2 Introduction Genetics has long been the central field of biology and it’s central dogma states that DNA leads to RNA, which leads to protein and ultimately determines human health or sickness1. The Human Genome Project marked a great triumph for humanity and researchers expected to solve the riddle of many complex diseases with the knowledge gleamed from this project. However, many more questions were raised than answered. Several rare genetic disorders including hemophilia and cystic fibrosis were explained by alterations in the genetic code but true genetic diseases only affect about one percent of the human population2. -
Botany Genetics Mendelian Inheritance
References 1. Elrod S., Stansfield W., 2002, Genetics, 4th Edition, Tata McGraw-Hill 2. Strickberger M. W., 1985, Genetics, 3rd Edition, Macmillan Publishing Company 3. Griffiths A. J., Wessler S.R., Lewontin R.C., Carrol S. B., 2008, Introduction to Genetic Analysis, 9th Edition, W. H. Freeman and Company 4. Klug W.S., Cumming M.R., Spencer C. A., Palladino M. A., 2009, Concepts of Genetics, 9th Edition, Benjamin Cummings Publication 5. Tamarin R. H., 2002, Principles of Genetics, 7th Edition, Tata McGraw-Hill 6. Hartwell L.H., Hood L., Goldberg M.L., Reynolds A.E., Silver L. M., Veres R. C., 2004, Genetics, 2nd Edition, McGraw-Hill 7. Pierce B.A., Genetics: A Conceptual Approach, 4th edition, W.H. Freeman 8. T.H. Noel Ellis, Julie M.I. Hofer, Gail M. Timmerman-Vaughan, Clarice J. Coyne and Roger P. Hellens, 2011, Mendel, 150 years on, Trends in Plant Science, Vol. 16, 590-596 Genetics Botany Mendelian Inheritance Learn More / Supporting Materials / Source of Further Reading 2.1 Glossary Starting Term Defination Related Term Character <Character> < Genotype > < Genotype of an organism is the gene combination it possesses. Genotype of phenotypically yellow seeded F1 may be YY or Yy.> <Character> < Phenotype > < Phenotype refers to the observable attributes of an organism. Plants with either of the two genotypes Yy or Yy are phenotypically yellow seeded.> <Character> < Homozygote > < A plant with a pair of identical alleles is called as Homozygote (Y/Y or y/y).> <Character> < Heterozygote > < a plant in which the <term2> allele of the pair differ is called as heterozygote (Y/y).> <Character> < locus > < A locus (plural: loci) is the location of a gene on a chromosome. -
Elements of Genetics
GENETICS AND PLANT BREEDING Elements of Genetics Dr. B. M. Prasanna National Fellow Division of Genetics Indian Agricultural Research Institute New Delhi-110012 (12-06- 2007) CONTENTS Introduction History Cell Cell Division Special Chromosomes Dominance Relationships Gene Interactions Multiple Alleles Sex Determination Sex Linkage Linkage and Crossing Over Genetic Mapping Structural Changes in Chromosomes Numerical Changes in Chromosomes Nature of the Genetic Material Gene Regulation Operon Concept Gene Concept Mutation Polygenic and Quantitative Inheritance Extrachromosomal Inheritance Plant Tissue Culture Keywords Mitosis, Meiosis 1 Introduction In biology, heredity is the passing on of characteristics from one generation to the next. It is the reason why offspring look like their parents. It also explains why cats always give birth to kittens and never puppies. The process of heredity occurs among all living organisms, including animals, plants, bacteria, protists and fungi. Genetic variation refers to the variation in a population or species. Genetics is the study of heredity and variation in living organisms. Two research approaches were historically important in helping investigators understand the biological basis of heredity. The first of these approaches, ‘transmission genetics’, involved crossing organisms and studying the offsprings' traits to develop hypotheses about the mechanisms of inheritance. The second approach involved using cytological techniques to study the machinery and processes of cellular reproduction. This approach laid a solid foundation for the more conceptual understanding of inheritance that developed as a result of transmission genetics. Ever since 1970s, with the advent of molecular tools and techniques, geneticists are able to intensively analyze genetic basis of trait variation in various organisms, including plants, animals and humans. -
Epigenetics the Epicenter for Future Anesthesia Research?
Epigenetics The Epicenter for Future Anesthesia Research? Creed M. Stary, M.D., Ph.D., Hemal H. Patel, Ph.D., David M. Roth, M.D., Ph.D. ONRAD Hal Wadding- approximately 80% of the human C ton (1905–1975), a British genome is indeed associated with embryologist, geneticist, and phi- at least one biochemical func- losopher, proposed the concept tion: regulation of the expression of epigenetics, defined broadly of coding genes.4 These results in as the bridge between an organ- part explain the observation that Downloaded from http://pubs.asahq.org/anesthesiology/article-pdf/123/4/743/372860/20151000_0-00008.pdf by guest on 26 September 2021 ism’s inheritable genome and the the majority of RNA species that observable traits of that organism, are generated are not subsequently such as morphology, physiologi- translated to protein5 and demon- cal properties, and behavior.1 For strate that gene regulation is far example, although a majority of more complex than has been tra- a given organism’s cells share an ditionally believed. identical set of chromosomes, The list of noncoding RNAs embryological development has grown from transfer RNAs results in a wide diversity of cell and ribosomal RNAs to include types, each with individualized the discovery of small nucleolar gene expression patterns and func- “miRs are small (19 to 22 RNAs, long noncoding RNAs, tions. In this light, epigenetics is and, the topic of the current generally now defined as the study nucleotides), highly conserved study by Qiao et al., miRs. miRs of gene expression processes that across species, and.… [Their are important posttranscriptional are impacted by the external envi- regulators that interact with ronment and can be passed to suc- binding to target genes] multiple target mRNAs to coor- cessive generations, independently dinately regulate protein expres- of changes in Watson-Crick DNA results in gene silencing or sion. -
Molecular Biology and Applied Genetics
MOLECULAR BIOLOGY AND APPLIED GENETICS FOR Medical Laboratory Technology Students Upgraded Lecture Note Series Mohammed Awole Adem Jimma University MOLECULAR BIOLOGY AND APPLIED GENETICS For Medical Laboratory Technician Students Lecture Note Series Mohammed Awole Adem Upgraded - 2006 In collaboration with The Carter Center (EPHTI) and The Federal Democratic Republic of Ethiopia Ministry of Education and Ministry of Health Jimma University PREFACE The problem faced today in the learning and teaching of Applied Genetics and Molecular Biology for laboratory technologists in universities, colleges andhealth institutions primarily from the unavailability of textbooks that focus on the needs of Ethiopian students. This lecture note has been prepared with the primary aim of alleviating the problems encountered in the teaching of Medical Applied Genetics and Molecular Biology course and in minimizing discrepancies prevailing among the different teaching and training health institutions. It can also be used in teaching any introductory course on medical Applied Genetics and Molecular Biology and as a reference material. This lecture note is specifically designed for medical laboratory technologists, and includes only those areas of molecular cell biology and Applied Genetics relevant to degree-level understanding of modern laboratory technology. Since genetics is prerequisite course to molecular biology, the lecture note starts with Genetics i followed by Molecular Biology. It provides students with molecular background to enable them to understand and critically analyze recent advances in laboratory sciences. Finally, it contains a glossary, which summarizes important terminologies used in the text. Each chapter begins by specific learning objectives and at the end of each chapter review questions are also included. -
A Brief History of Genetics
A Brief History of Genetics A Brief History of Genetics By Chris Rider A Brief History of Genetics By Chris Rider This book first published 2020 Cambridge Scholars Publishing Lady Stephenson Library, Newcastle upon Tyne, NE6 2PA, UK British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Copyright © 2020 by Chris Rider All rights for this book reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the copyright owner. ISBN (10): 1-5275-5885-1 ISBN (13): 978-1-5275-5885-4 Cover A cartoon of the double-stranded helix structure of DNA overlies the sequence of the gene encoding the A protein chain of human haemoglobin. Top left is a portrait of Gregor Mendel, the founding father of genetics, and bottom right is a portrait of Thomas Hunt Morgan, the first winner of a Nobel Prize for genetics. To my wife for her many years of love, support, patience and sound advice TABLE OF CONTENTS List of Figures.......................................................................................... viii List of Text Boxes and Tables .................................................................... x Foreword .................................................................................................. xi Acknowledgements ................................................................................. xiii Chapter 1 ................................................................................................... -
1 Genetics, Genomics and Cell Biology, Spring 2013 Instructors
Genetics, Genomics and Cell Biology, Spring 2013 Monday, Wednesday, Friday 9-10 AM, 2050 VLSB Instructors Michael Levine, Ph.D. ([email protected]; office hours Friday 3-5 PM, 243 Dwinelle) Craig Miller, Ph.D. ([email protected]; office hours: Friday 3-5 PM, 243 Dwinelle) Rebecca Heald, Ph.D. ([email protected]; office hours: TBA) GSIs Jeremy Amon ([email protected]; office hours TBA) Peter Combs ([email protected]; office hours TBA) Anna Maria Desai ([email protected]; office hours TBA) Anna Park ([email protected]; office hours TBA) Jennifer Parks ([email protected]; office hours TBA) Course focus This course will introduce students to key concepts in genetic analysis, eukaryotic cell biology, and state-of-the-art approaches in genomics. Lectures will highlight basic knowledge of cellular processes that form the basis for human diseases. Prerequisite courses will have introduced students to the concepts of cells, the central dogma of molecular biology, and gene regulation. Emphasis in this course will be on eukaryotic cell processes, including cellular organization, dynamics and signaling. Grading Midterm 1 (Feb 21, 7:00-9:00 PM) 100 points Midterm 2 (Mar 14, 7:00-9:00 PM) 100 points Final exam (May 13, 7-10 PM) 200 points Quizzes (3 total, 25 points each) 75 points Mini Quizzes (10 total, 2.5 points each) 25 points Total 500 points Quizzes are given during discussion sections with weekly mini quizzes and one 25 point quiz during each third of the course. Your lowest mini quiz score will be dropped and your mini quiz total score will be based upon the remaining 9 mini quizzes. -
Clinical Exome Sequencing Tip Sheet – Medicare Item Numbers 73358/73359
Clinical exome sequencing Tip sheet – Medicare item numbers 73358/73359 Glossary Chromosome microarray (CMA or molecular Monogenic conditions (as opposed karyotype): CMA has a Medicare item number to polygenic or multifactorial conditions) are for patients presenting with intellectual caused by variants in a single gene. Variants disability, developmental delay, autism, or at may be inherited (dominant or recessive least two congenital anomalies. CMA is the fashion), or may occur spontaneously (de recommended first line test in these cases as novo) showing no family history. it can exclude a chromosome cause of disease which is unlikely to be detected by Whole exome sequence – sequencing only exome. the protein coding genes (exons). The exome is ~2% of the genome and contains ~85% of Gene panel is a set of genes that are known to disease-causing gene variants. be associated with a phenotype or disorder. They help narrow down the search Whole genome sequence – sequencing the for variants of interest to genes with evidence entire genome (all genes, including coding linking them to particular phenotypes and noncoding regions) Human phenotype ontology (HPO) terms Singleton – Analysis of the child only. describe a phenotypic abnormality using a Trio – analysis of the child and both biological standard nomenclature. Ideally, all clinicians parents. and scientists are using the same terms. Variant - A change in the DNA code that Mendeliome refers to the ~5,000 genes (out of differs from a reference genome. about 20,000 protein coding genes) that are known to be associated with monogenic disease. As variants in new genes are identified with evidence linking them with human disease, they are added to the Mendeliome.