Bulletin 2021-22 Department of and Molecular (09/29/21)

Visit our website for more information about our faculty (http:// Department of biochem.wustl.edu/faculty/) and their appointments.

Biochemistry and B Molecular Biophysics Wayne Morris Barnes, PHD Associate Professor of Biochemistry and Molecular Biophysics (primary appointment) The faculty of the Department of Biochemistry and Molecular BA University of CA Riverside 1969 Biophysics perform research in a broad spectrum of biomedically PHD Univ of Wisconsin Madison 1974 relevant areas, including DNA and RNA structure and enzymology; folding, misfolding and aggregation; Gregory R. Bowman, PHD cellular mechanics; membrane receptor-mediated signaling; and Associate Professor of Biochemistry and Molecular Biophysics hemostasis, thrombosis and vascular . The department (primary appointment) offers training opportunities at the crossroads of biochemistry, Adjunct Assistant Professor of biophysics, systems biology, proteomics, computational science Associate Director of the CSELS and pharmacological sciences. PHD Stanford University 2010 BS Cornell University 2006 The department's approaches to research focus on understanding the energetics, structure and mechanisms Melissa Diane Stuchell Brereton, PHD, PHD of biological processes. Investigators employ a variety Instructor in Biochemistry and Molecular Biophysics (primary of experimental methods (e.g., X-ray crystallography, appointment) nuclear magnetic resonance, , optical BS University of MO St Louis 2001 , , rapid kinetics) in combination PHD University of Utah 2007 with computational approaches to unravel the molecular BS University of MO St Louis 2000 underpinnings of processes of relevance to health and disease. PHD University of Utah 2006 Novel single- methods are providing new insight into the Peter M Burgers, MS, PHD molecular details of mechanisms and macromolecule Marvin A. Brennecke Professor of Biological Chemistry (primary dynamics. The high-throughput screening of chemical libraries appointment) and the use of synthetic medicinal chemistry to develop small- MS Leiden University 1972 molecule probes of biological systems provide new avenues PHD Leiden University 1977 for translational research and the development of experimental BS Leiden University 1969 therapeutics. The faculty in the department organize and teach basic science C courses in the medical school curriculum. In the Graduate John A Cooper, MD, PHD School curriculum, the faculty teach courses in Nucleic Acids Professor of Biochemistry and Molecular Biophysics (primary & (Biol 548), Chemistry and of appointment) (Biol 5357), and Macromolecular Interactions Head of the Department of Biochemistry (Biol 5312). The overarching theme of these courses is to Professor of Cell Biology and Physiology understand the principles of the molecular interactions that MD Johns Hopkins University 1982 underlie the biological process of health and disease. Students BS Brown University 1977 in the School of and the Graduate School are eligible PHD Johns Hopkins University 1983 for these courses and may elect to pursue biomedical research under the direction of our faculty. A full listing of advanced D course topics (https://biochem.wustl.edu/studentinfo/courses/) Vishnu C Damalanka, PHD, MS can be found on our website. Instructor in Biochemistry and Molecular Biophysics (Pending Website: http://biochem.wustl.edu Dean's Approval) (primary appointment) PHD Wichita St University 2017 Faculty BS Andhra University 2003 MS Andhra University 2005 John A. Cooper, MD, PhD (https://biochem.wustl.edu/ faculty/cooper/) Greg Dekoster, PHD Department Chair Instructor in Biochemistry & Molecular Biophysics (primary appointment) PHD University of Iowa 1997

1 Bulletin 2021-22 Department of Biochemistry and Molecular Biophysics (09/29/21)

BA Monmouth College 1990 PHD Washington Univ in St. Louis 2017 Roland Ellwood Dolle, PHD, MS I Associate Professor of Biochemistry and Molecular Biophysics (primary appointment) Maxenia Garcia Ilagan, PHD PHD University of Pennsylvania 1984 Associate Professor of Biochemistry and Molecular Biophysics BS Arizona State University 1978 (primary appointment) MS State University of New York 1980 Associate Professor of Developmental Biology BS School Not Listed 1992 E PHD University of Missouri 2000 Elliot L Elson, PHD J Emeritus Professor of Biochemistry and Molecular Biophysics (primary appointment) James W Janetka, PHD PHD Stanford University 1966 Professor of Biochemistry and Molecular Biophysics (primary BA Harvard University 1959 appointment) PHD Univ of Wisconsin Madison 1996 F BS University of Illinois 1990 Carl Frieden, PHD K Professor of Biochemistry and Molecular Biophysics (primary appointment) Michael S Kinch, PHD BA Carleton College 1951 Professor of Biochemistry and Molecular Biophysics (primary PHD Univ of Wisconsin Madison 1955 appointment) Associate Vice Chancellor and Director Center Research G Innovation in Biotechology Professor of Radiation Oncology Eric A Galburt, PHD BS Ohio State University 1989 Associate Professor of Biochemistry and Molecular Biophysics PHD Duke University 1993 (primary appointment) PHD University of Washington 2002 Alexander Kozlov, PHD, MS Instructor in Biochemistry and Molecular Biophysics (primary Roberto Galletto, MS, PHD appointment) Associate Professor of Biochemistry and Molecular Biophysics PHD Moscow State University 1994 (primary appointment) MS Moscow State University 1983 MS University of Genova 1996 PHD University of Texas Galveston 2002 Andrzej Modest Krezel, MS, PHD Associate Professor of Biochemistry and Molecular Biophysics Lina Greenberg, PHD (Pending Executive Faculty Approval) (primary appointment) Instructor in Biochemistry and Molecular Biophysics (primary MS University of Warsaw 1986 appointment) PHD Univ of Wisconsin Madison 1991 PHD Tufts University 2010 BS Brandeis University 2004 L Michael Jonathan Greenberg, PHD Shuang Li, PHD Assistant Professor of Biochemistry and Molecular Biophysics Instructor in Biochemistry and Molecular Biophysics (Pending (primary appointment) Dean's Approval) (primary appointment) BS Brandeis University 2004 PHD Capital Normal University 2015 PHD Boston University 2010 Weikai Li, PHD, MS H Associate Professor of Biochemistry and Molecular Biophysics (primary appointment) Kathleen Hall, PHD BS East China Univ of Sci & Tech 1993 Professor of Biochemistry and Molecular Biophysics (primary PHD Yale University 2004 appointment) MS University of Tenn Chattanooga 1998 PHD University of CA Berkeley 1985 BS University of Minnesota 1974 Timothy M Lohman, PHD Brennecke Professor of Biophysics in Biochemistry and Alexander Steven Holehouse, PHD Molecular Biophysics (primary appointment) Assistant Professor of Biochemistry and Molecular Biophysics PHD Univ of Wisconsin Madison 1977 (primary appointment)

2 Bulletin 2021-22 Department of Biochemistry and Molecular Biophysics (09/29/21)

BA Cornell University 1973 W M Gabriel Waksman, MS, PHD Adjunct Professor of Biochemistry and Molecular Biophysics Garland R Marshall, PHD (primary appointment) Professor of Biochemistry and Molecular Biophysics (primary MS School Not Listed 1980 appointment) PHD School Not Listed 1982 Professor of Biomedical BS School Not Listed 1979 PHD Rockefeller University 1966 BS California Institute Technolo 1962 Katherine Anne Henzler Wildman, PHD Adjunct Associate Professor of Biochemistry and Molecular Joseph B Monahan, PHD Biophysics (primary appointment) Adjunct Assistant Professor of Biochemistry and Molecular BS Cornell University 1998 Biophysics (primary appointment) PHD University of Michigan 2003 BS State Univ of NY Buffalo 1977 PHD Univ South Carolina Columbia 1983 Z N Rui Zhang, PHD Assistant Professor of Biochemistry and Molecular Biophysics Natalie Marie Niemi, PHD (primary appointment) Assistant Professor of Biochemistry and Molecular Biophysics BS Nanjing Medical University 2005 (primary appointment) PHD Baylor University 2010 PHD Van Andel Research Institute 2012 BS University of Michigan 2005 Research Electives O Biochemistry and Molecular Biophysics Michael D Onken, PHD Research Electives Associate Professor of Biochemistry and Molecular Biophysics (primary appointment) During the fourth year, opportunities exist for many varieties of PHD Washington Univ in St. Louis 2000 advanced clinical or research experiences. BA Washington Univ in St. Louis 1990 Wayne M. Barnes, PhD P McDonnell Sciences Building, 2nd Floor Linda J Pike, PHD Phone: 314-362-3351 Alumni Endowed Professor of Biochemistry and Molecular Inventing a new way to sequence DNA; PCR at one temp; RT- Biophysics (primary appointment) enabled Taq pol PHD Duke University 1980 BS University of Delaware 1975 Greg Bowman, PhD R South Building, 2nd Floor Janice Lee Robertson, PHD Phone: 314-362-7433 Assistant Professor of Biochemistry and Molecular Biophysics The Bowman lab seeks to understand how (primary appointment) gives rise to functional processes like allosteric communication PHD Cornell University 2009 between distant sites and to exploit our insight into this shape- BS University of Toronto 2002 shifting to design new drugs and . Ana Maria Ruiz Manzano, PHD Assistant Professor of Biochemistry and Molecular Biophysics Peter M.J. Burgers, PhD (primary appointment) South Building, 1st Floor PHD Universidad Automoma de Madrid 2004 Phone: 314-362-3872 S of DNA replication and damage response in Andrea Soranno, MS, PHD yeast and humans Assistant Professor of Biochemistry and Molecular Biophysics (primary appointment) MS University of Milan 2005 PHD University of Milan 2008

3 Bulletin 2021-22 Department of Biochemistry and Molecular Biophysics (09/29/21)

Rational structure-based and synthesis for cancer John Cooper, MD, PhD and infectious disease South Building, 2nd Floor Phone: 314-362-0287 Andrzej Krezel, PhD Molecular mechanisms of cell motility and cytoskeleton assembly McDonnell Sciences Building, 2nd Floor Phone: 314-362-8482 Carl Frieden, PhD Structural biology of transcriptional regulation in the gastric McDonnell Sciences Building, 2nd Floor pathogen Helicobacter pylori Phone: 314-362-3344 , aggregation, intrinsically disordered proteins, Weikai Li, PhD methods, ApoE lipoproteins and Alzheimer's McDonnell Sciences Building, 2nd Floor disease Phone: 314-362-8687 Structural and biochemical studies of membrane proteins Eric A. Galburt, PhD supporting blood coagulation McDonnell Sciences Building, 2nd Floor Phone: 314-362-5201 Timothy M. Lohman, PhD Biophysical studies of transcription initiation in eukaryotes and North Building, 2nd Floor mycobacterial tuberculosis Phone: 314-362-4393 Mechanisms of DNA-protein interactions; DNA motor proteins Roberto Galletto, PhD (helicases) and SSB proteins McDonnell Sciences Building, 2nd Floor Phone: 314-362-4368 Garland R. Marshall, PhD Mechanistic studies of DNA motor proteins Cancer Research Building, 2nd Floor Phone: 314-935-7911 Michael Greenberg, PhD A major focus is molecular recognition: the basis of McDonnell Sciences Building, 2nd Floor intermolecular interactions and specificity seen in drug and Phone: 314-362-8670 hormone receptors and in antigen-antibody and substrate- enzyme systems. Our lab is focused on cytoskeletal molecular motors in health and disease. We are currently studying the effects of mutations that cause heart disease. Linda Pike, PhD McDonnell Sciences Building, 2nd Floor Phone: 314-362-9502 Kathleen Hall, PhD South Building, 2nd Floor Our focus is on the mechanisms of action of growth factors and Phone: 314-362-4196 polyphosphoinositide metabolism. We study RNA folding and RNA binding to proteins. Janice Robertson, PhD McDonnell Sciences Building, 2nd Floor Alex Holehouse, PhD Phone: 314-273-7758 McDonnell Sciences Building, 2nd Floor Phone: 314-273-8371 Our goal is to understand how and why membrane proteins fold, form stable complexes, and achieve conformational stability Understand how function is encoded into disordered sequences inside of the oil-filled cell membrane. using a combination of computational and experimental approaches Andrea Soranno, PhD South Building, 2nd Floor Jim Janetka, PhD Phone: 314-273-1632 Cancer Research Building, 2nd Floor Phone: 314-362-0509 Our main research interests are the physical principles and molecular mechanisms that determine biomolecular function.

4 Bulletin 2021-22 Department of Biochemistry and Molecular Biophysics (09/29/21)

Rui Zhang, PhD McDonnell Sciences Building, 2nd Floor Phone: 314-273-1663 We combine single-molecule fluorescence spectroscopy and concepts from polymer physics to investigate intrinsically disordered proteins. We also develop innovative methods to study macromolecular conformations and dynamics within cells and in membraneless organelles.

Courses The Department of Biochemistry and Molecular Biophysics also offers courses through the Graduate School. For a full listing of courses offered, please visit the university online course catalog (https://courses.wustl.edu/CourseInfo.aspx? sch=L&dept=L41&crslvl=5:9). Visit online course listings to view offerings for M15 Biochem (https://courses.wustl.edu/CourseInfo.aspx?sch=M&dept=M15).

M15 Biochem 502 Molecular Foundations of Medicine This course is designed primarily for medical students and will cover fundamental aspects of biochemistry and cell biology. The course begins with a treatment of and the function of proteins in the cytoskeleton and cell motility. The principles of enzyme kinetics and regulation are then discussed and basic pathways for the synthesis and metabolism of carbohydrates and lipids are introduced. This leads in to a discussion of membrane structure and the function cellular organelles in biological processes including energy production, protein degradation and protein trafficking. Small group case study sections serve to link the basic science to the clinic. Credit 46.5 units.

M15 Biochem 5068 Fundamentals of Molecular Cell Biology Same as Arts and Sciences L41 5068. Credit 47 units.

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